(Q35119688)

6 August 2017

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title

Manipulation of the mouse genome: a multiple impact resource for drug discovery and development (English)

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6 August 2017

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1 reference

https://api.crossref.org/works/10.1016/S0167-7799(03)00087-8

29 December 2023

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https://api.crossref.org/works/10.1016/S0167-7799(03)00087-8

29 December 2023

author name string

Haydn Prosser

series ordinal

1

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6 August 2017

Sohaila Rastan

series ordinal

2

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6 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12727384

29 December 2023

publication date

1 May 2003

1 reference

full work available at URL

6 August 2017

https://api.elsevier.com/content/article/PII:S0167779903000878?httpAccept=text/xml

1 reference

DOI

https://api.crossref.org/works/10.1016/S0167-7799(03)00087-8

https://api.elsevier.com/content/article/PII:S0167779903000878?httpAccept=text/plain

29 December 2023

1 reference

DOI

https://api.crossref.org/works/10.1016/S0167-7799(03)00087-8

29 December 2023

published in

Trends in Biotechnology

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6 August 2017

21

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6 August 2017

5

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6 August 2017

224-232

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Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Construction of gene targeting vectors from lambda KOS genomic libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Recombineering: a powerful new tool for mouse functional genomics

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Engineering a mouse balancer chromosome

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Transgenic knockouts as part of high-throughput, evidence-based target selection and validation strategies

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Conditional control of gene expression in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Recombinase-mediated gene activation and site-specific integration in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Regulation of Cre recombinase activity by the synthetic steroid RU 486.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Inducible site-specific recombination in the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Ligand-activated site-specific recombination in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Temporally and spatially regulated somatic mutagenesis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Inducible gene knockouts in the small intestinal and colonic epithelium

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Ubiquitous postnatal LoxP recombination using a doxycycline auto-inducible Cre transgene (DAI-Cre)

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

The temporal requirement for endothelin receptor-B signalling during neural crest development

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Ligand-inducible and liver-specific target gene expression in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

A humanized system for pharmacologic control of gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Controlling mammalian gene expression with small molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

A regulatory system for use in gene transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Capitalizing on large-scale mouse mutagenesis screens

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Functional identification of the mouse circadian Clock gene by transgenic BAC rescue

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Mouse mutants from chemically mutagenized embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

A gene-driven approach to the identification of ENU mutants in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Central control of bone formation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Dissection of the complex role of apolipoprotein E in lipoprotein metabolism and atherosclerosis using mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Modelling haematopoietic malignancies in the mouse and therapeutical implications

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Generation of mice expressing the human glucagon receptor with a direct replacement vector

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Whole-animal cellular and molecular imaging to accelerate drug development

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

In vivo patterns of heme oxygenase-1 transcription.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Application of genetically altered models as replacement for the lifetime mouse bioassay in pharmaceutical development

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

The use of transgenic mice in pharmacokinetic and pharmacodynamic studies

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Cytochrome P450-null mice

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Genetic analysis of the mouse brain proteome.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2803%2900087-8

7 January 2021

Identifiers

DOI

1 reference

release_jbcg6vy6g5h43id4z7yyhod56m

6 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jbcg6vy6g5h43id4z7yyhod56m

24 November 2022

mapped directly with Wikidata item

1 reference