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Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.
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Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
title
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
main subject
protein evolution
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rapid evolution
1 reference
based on heuristic
inferred from title
author
Thomas Dever
series ordinal
4
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Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
author name string
Stefan Rothenburg
series ordinal
1
1 reference
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Europe PubMed Central
PMCID
3142916
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
Eun Joo Seo
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2
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Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
James S Gibbs
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3
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PMCID
3142916
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
Katharina Dittmar
series ordinal
5
1 reference
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Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
publication date
30 November 2008
1 reference
stated in
Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
published in
Nature Structural & Molecular Biology
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Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
volume
16
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Europe PubMed Central
PMCID
3142916
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
page(s)
63-70
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Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
issue
1
1 reference
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Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/nsmb.1529
0 references
cites work
Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Poxvirus host range genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Innate recognition of viruses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Protein kinase PKR plays a stimulus- and virus-dependent role in apoptotic death and virus multiplication in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Interferon action and the double-stranded RNA-dependent enzymes ADAR1 adenosine deaminase and PKR protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Inhibition of PKR by RNA and DNA viruses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Innate immune recognition of nucleic acids: beyond toll-like receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Poxvirus tropism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
MAFFT version 5: improvement in accuracy of multiple sequence alignment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
HyPhy: hypothesis testing using phylogenies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Zoonotic poxvirus infections in humans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
The Crystal Structure of the N-terminal Region of the Alpha Subunit of Translation Initiation Factor 2 (eIF2α) from Saccharomyces cerevisiae Provides a View of the Loop Containing Serine 51, the Target of the eIF2α-specific Kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host range
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Gene-specific regulation by general translation factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Pseudosubstrate inhibition of protein kinase PKR by swine pox virus C8L gene product
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
PAML: a program package for phylogenetic analysis by maximum likelihood
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Phylogenetic analysis using parsimony and likelihood methods
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
13 July 2018
Rana catesbeiana virus Z (RCV-Z): a novel pathogenic ranavirus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
27 September 2018
Comparison of the eIF-2alpha homologous proteins of seven ranaviruses (Iridoviridae).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
27 September 2018
The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
27 September 2018
Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
16 November 2018
Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
16 November 2018
Tertiary Windowing to Detect Positive Diversifying Selection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3142916
retrieved
16 November 2018
The dsRNA-dependent protein kinase, PKR and cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNSMB.1529
retrieved
31 March 2020
TreeSAAP: Selection on Amino Acid Properties using phylogenetic trees
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNSMB.1529
retrieved
31 March 2020
Identifiers
DOI
10.1038/NSMB.1529
1 reference
stated in
Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
PMCID
3142916
1 reference
stated in
Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
PubMed ID
19043413
1 reference
stated in
Europe PubMed Central
PMCID
3142916
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19043413%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
ResearchGate publication ID
23556374
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