(Q35128906)

6 August 2017

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title

Pharmacological strategies for muscular dystrophy (English)

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6 August 2017

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2

Kay E Davies

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6 August 2017

Tejvir S. Khurana

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12750741

3 January 2024

Kay E. Davies

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12750741

3 January 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12750741

3 January 2024

publication date

1 May 2003

1 reference

full work available at URL

6 August 2017

https://www.nature.com/articles/nrd1085.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/NRD1085

https://www.nature.com/articles/nrd1085

3 January 2024

1 reference

https://api.crossref.org/works/10.1038/NRD1085

Nature Reviews Drug Discovery

3 January 2024

published in

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6 August 2017

2

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6 August 2017

379-390

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6 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrd1085

6 August 2017

0 references

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(CA) repeat polymorphism in the chromosome 18 encoded dystrophin-like protein

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Small-caliber skeletal muscle fibers do not suffer deleterious consequences of dystrophic gene expression

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Expression of full-length utrophin prevents muscular dystrophy in mdx mice

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Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene

31 March 2020

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The utrophin and dystrophin genes share similarities in genomic structure

31 March 2020

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A study of short utrophin isoforms in mice deficient for full-length utrophin

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Molecular and functional analysis of the utrophin promoter

31 March 2020

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A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy

31 March 2020

1 reference

Utrophin transcription is activated by an intronic enhancer

31 March 2020

1 reference

A- and B-utrophin have different expression patterns and are differentially up-regulated in mdx muscle

31 March 2020

1 reference

Targeting transcription to the neuromuscular synapse

31 March 2020

1 reference

Neuregulin and ErbB receptor signaling pathways in the nervous system

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Induction of utrophin gene expression by heregulin in skeletal muscle cells: role of the N-box motif and GA binding protein

31 March 2020

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Activation of utrophin promoter by heregulin via the ets-related transcription factor complex GA-binding protein alpha/beta

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Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter

31 March 2020

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The role of basal and myogenic factors in the transcriptional activation of utrophin promoter A: implications for therapeutic up-regulation in Duchenne muscular dystrophy

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Sp1 and the ets-related transcription factor complex GABP alpha/beta functionally cooperate to activate the utrophin promoter.

31 March 2020

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Ets, Ap-1 and GATA factor families regulate the utrophin B promoter: potential regulatory mechanisms for endothelial-specific expression

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Transcriptional activation of the utrophin promoter B by a constitutively active Ets-transcription factor

31 March 2020

1 reference

Nitric oxide and l-arginine cause an accumulation of utrophin at the sarcolemma: a possible compensation for dystrophin loss in Duchenne muscular dystrophy

31 March 2020

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Muscular nitric oxide synthase (muNOS) and utrophin

31 March 2020

1 reference

Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice

31 March 2020

1 reference

Overexpression of the cytotoxic T cell GalNAc transferase in skeletal muscle inhibits muscular dystrophy in mdx mice

31 March 2020

1 reference

Increased expression of utrophin in a slow vs. a fast muscle involves posttranscriptional events

31 March 2020

1 reference

Glucocorticoid-mediated regulation of utrophin levels in human muscle fibers

31 March 2020

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Non-toxic ubiquitous over-expression of utrophin in the mdx mouse

31 March 2020

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Prevention of pathology in mdx mice by expression of utrophin: analysis using an inducible transgenic expression system.

31 March 2020

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Dystrophic phenotype of canine X-linked muscular dystrophy is mitigated by adenovirus-mediated utrophin gene transfer.

31 March 2020

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Current protocol of a research phase I clinical trial of full-length dystrophin plasmid DNA in Duchenne/Becker muscular dystrophies. Part I: rationale.

31 March 2020

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Current protocol of a research phase I clinical trial of full-length dystrophin plasmid DNA in Duchenne/Becker muscular dystrophies. Part II: clinical protocol

31 March 2020

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31 March 2020

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Randomized, double-blind six-month trial of prednisone in Duchenne's muscular dystrophy

31 March 2020

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Steroids in Duchenne muscular dystrophy; pilot study of a new low-dosage schedule

31 March 2020

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A multicenter, double-blind, randomized trial of deflazacort versus prednisone in Duchenne muscular dystrophy

31 March 2020

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Intracellular calcium accumulation in Duchenne dystrophy and other myopathies: a study of 567,000 muscle fibers in 114 biopsies

31 March 2020

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Expression profiling reveals metabolic and structural components of extraocular muscles

31 March 2020

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Increased activity of calcium leak channels in myotubes of Duchenne human and mdx mouse origin

31 March 2020

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Proteolysis results in altered leak channel kinetics and elevated free calcium in mdx muscle.

31 March 2020

1 reference

Long-term study of Ca(2+) homeostasis and of survival in collagenase-isolated muscle fibres from normal and mdx mice

31 March 2020

1 reference

Effect of dantrolene in Duchenne muscular dystrophy

31 March 2020

1 reference

Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition.

31 March 2020

1 reference

Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathology

31 March 2020

1 reference

Mitochondrial calcium overload: A general mechanism for cell-necrosis in muscle diseases

31 March 2020

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Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells

31 March 2020

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31 March 2020

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Monoclonal antibody analysis of mononuclear cells in myopathies. III: Immunoelectron microscopy aspects of cell-mediated muscle fiber injury

31 March 2020

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A role for mast cells in the progression of Duchenne muscular dystrophy? Correlations in dystrophin-deficient humans, dogs, and mice

31 March 2020

1 reference

Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology

31 March 2020

1 reference

Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle

31 March 2020

1 reference

Elevated basic fibroblast growth factor in the serum of patients with Duchenne muscular dystrophy

31 March 2020

1 reference

Helper (CD4(+)) and cytotoxic (CD8(+)) T cells promote the pathology of dystrophin-deficient muscle

31 March 2020

1 reference

Duchenne-like myopathy in double-mutant mdx mice expressing exaggerated mast cell activity

31 March 2020

1 reference

Clenbuterol, a beta 2-agonist, retards wasting and loss of contractility in irradiated dystrophic mdx muscle

31 March 2020

1 reference

Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells

31 March 2020

1 reference

Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study

31 March 2020

1 reference

Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice

31 March 2020

1 reference

Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice

31 March 2020

1 reference

Improved contractile function of the mdx dystrophic mouse diaphragm muscle after insulin-like growth factor-I administration

31 March 2020

1 reference

Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1.

31 March 2020

1 reference

The mh gene causing double-muscling in cattle maps to bovine Chromosome 2.

31 March 2020

1 reference

A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle

31 March 2020

1 reference

Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member

31 March 2020

1 reference

A missense mutant myostatin causes hyperplasia without hypertrophy in the mouse muscle

31 March 2020

1 reference

Dominant negative myostatin produces hypertrophy without hyperplasia in muscle

31 March 2020

1 reference

GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor binding

31 March 2020

1 reference

Regulation of myostatin activity and muscle growth

31 March 2020

1 reference

Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation

31 March 2020

1 reference

The myostatin gene is a downstream target gene of basic helix-loop-helix transcription factor MyoD.

31 March 2020

1 reference

Myostatin inhibits myoblast differentiation by down-regulating MyoD expression.

31 March 2020

1 reference

Functional improvement of dystrophic muscle by myostatin blockade.

31 March 2020

1 reference

Loss of myostatin attenuates severity of muscular dystrophy in mdx mice

31 March 2020

1 reference

Collaborative translational research leading to multicenter clinical trials in Duchenne muscular dystrophy: the Cooperative International Neuromuscular Research Group (CINRG).

31 March 2020

1 reference

Pre-clinical screening of drugs using the mdx mouse

31 March 2020

1 reference

Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice

31 March 2020

1 reference

Antisense-induced exon skipping restores dystrophin expression in DMD patient derived muscle cells

31 March 2020

1 reference

In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide

31 March 2020

1 reference

Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides

31 March 2020

1 reference

Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts

31 March 2020

1 reference

Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice

31 March 2020

1 reference

ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation

31 March 2020

1 reference

Different distributions of dystrophin and related proteins at nerve-muscle junctions

31 March 2020

series ordinal

45

1 reference

https://api.crossref.org/works/10.1038/NRD1085

3 January 2024

Identifiers

DOI

10.1038/NRD1085

1 reference

Dimensions Publication ID

6 August 2017

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