(Q35130769)

6 August 2017

title

Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor (English)

1 reference

6 August 2017

2

Charles A Dinarello

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6 August 2017

1

Eli C Lewis

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6 August 2017

language of work or name

English

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publication date

30 October 2006

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Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

published in

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6 August 2017

volume

103

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6 August 2017

issue

45

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6 August 2017

page(s)

16852-16857

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Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice

6 August 2017

cites work

1 reference

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Interleukin 18 (IL-18) upregulation in acute rejection of kidney allograft.

13 July 2018

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Generation and characterization of mice transgenic for human IL-18-binding protein isoform a

13 July 2018

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Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation

13 July 2018

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Role of interleukin-18 in acute graft-vs-host disease

13 July 2018

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1,25-dihydroxyvitamin D3 protects RINm5F and human islet cells against cytokine-induced apoptosis: implication of the antiapoptotic protein A20.

13 July 2018

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A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity

13 July 2018

1 reference

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Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production

13 July 2018

1 reference

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Functional IL-18 Is produced by primary pancreatic mouse islets and NIT-1 beta cells and participates in the progression towards destructive insulitis

13 July 2018

1 reference

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Effect of interleukin-18 on mouse core body temperature

13 July 2018

1 reference

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Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu

13 July 2018

1 reference

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Interleukin-18 regulates both Th1 and Th2 responses

13 July 2018

1 reference

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Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma

13 July 2018

1 reference

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Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor

13 July 2018

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Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells

13 July 2018

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Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response

13 July 2018

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Hyperresponsive febrile reactions to interleukin (IL) 1alpha and IL-1beta, and altered brain cytokine mRNA and serum cytokine levels, in IL-1beta-deficient mice

13 July 2018

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IFN-gamma, IGIF, and IDDM.

13 July 2018

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Human leukocytic pyrogen: purification and development of a radioimmunoassay

13 July 2018

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Interleukin-18 treatment options for inflammatory diseases

13 July 2018

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IL-18 binding protein fusion construct delays the development of diabetes in adoptive transfer and cyclophosphamide-induced diabetes in NOD mouse

27 September 2018

1 reference

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Cytokine expression during acute graft-versus-host disease after allogeneic peripheral stem cell transplantation.

27 September 2018

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Macrophage-derived interleukin-18 in experimental renal allograft rejection

27 September 2018

1 reference

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Lack of the mediators of innate immunity attenuate the development of autoimmune diabetes in mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636543

Essential pathogenic role of endogenous IL-18 in murine diabetes induced by multiple low doses of streptozotocin. Prevention of hyperglycemia and insulitis by a recombinant IL-18-binding protein: Fc construct

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636543

Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636543

A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636543

IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636543

Involvement of interleukin-18 in acute graft-versus-host disease in mice

25 October 2018

1 reference

12 December 2020

Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation

1 reference

12 December 2020

Systemic administration of IL-18 promotes diabetes development in young nonobese diabetic mice

1 reference

12 December 2020

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production

1 reference

12 December 2020

Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0607917103

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6 August 2017

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6 August 2017

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