(Q35134718)

6 August 2017

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title

TLR-induced negative regulatory circuits: role of suppressor of cytokine signaling (SOCS) proteins in innate immunity (English)

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6 August 2017

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2

Alexander Dalpke

1 reference

6 August 2017

Klaus Heeg

1

1 reference

PubMed ID

12763685

6 August 2017

language of work or name

English

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publication date

1 June 2003

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6 August 2017

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6 August 2017

21 Suppl 2

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6 August 2017

S61-7

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Innate immunity: impact on the adaptive immune response

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

The Toll-receptor family and control of innate immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

The Toll receptor family and microbial recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Toll-like receptors: key mediators of microbe detection.

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Interferons alpha and beta as immune regulators--a new look

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Role of type I interferons in T cell activation induced by CpG DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Drosophila MyD88 is an adapter in the Toll signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

TIRAP: an adapter molecule in the Toll signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Signaling through the JAK/STAT pathway, recent advances and future challenges

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Negative regulation of cytokine signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Modulation of STAT signaling by STAT-interacting proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

A new protein containing an SH2 domain that inhibits JAK kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Structure and function of a new STAT-induced STAT inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

A family of cytokine-inducible inhibitors of signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Twenty proteins containing a C-terminal SOCS box form five structural classes

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Regulation of SOCS-1 expression by translational repression

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frame

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Gigantism in mice lacking suppressor of cytokine signalling-2

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

SOCS3 is essential in the regulation of fetal liver erythropoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-alpha/beta

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

Listeria monocytogenes modulates macrophage cytokine responses through STAT serine phosphorylation and the induction of suppressor of cytokine signaling 3.

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

SOCS-1 participates in negative regulation of LPS responses

1 reference

https://api.crossref.org/works/10.1016%2FS0264-410X%2803%2900202-0

7 January 2021

10.1016/S0264-410X(03)00202-0

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12763685