(Q35140086)

6 August 2017

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title

Orally bioavailable beta 3-adrenergic receptor agonists as potential therapeutic agents for obesity and type-II diabetes (English)

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6 August 2017

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Baihua Hu

1

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6 August 2017

Lee L Jennings

series ordinal

2

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6 August 2017

publication date

1 January 2003

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Progress in medicinal chemistry

6 August 2017

published in

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6 August 2017

volume

41

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6 August 2017

page(s)

167-194

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Annual Deaths Attributable to Obesity in the United States

6 August 2017

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7 January 2021

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cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor

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Expression of three human beta-adrenergic-receptor subtypes in transfected Chinese hamster ovary cells

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Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans

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7 January 2021

Beta 3-adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse

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7 January 2021

Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered

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7 January 2021

Up-regulation of uncoupling proteins by beta-adrenergic stimulation in L6 myotubes

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7 January 2021

Time of Onset of Non-Insulin-Dependent Diabetes Mellitus and Genetic Variation in the β3-Adrenergic–Receptor Gene

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7 January 2021

Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres

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7 January 2021

Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent

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7 January 2021

Prodrugs of CL316243: a selective beta3-adrenergic receptor agonist for treating obesity and diabetes

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7 January 2021

Novel (4-piperidin-1-yl)-phenyl sulfonamides as potent and selective human beta(3) agonists

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7 January 2021

New oxadiazolidinedione derivatives as potent and selective human beta3 agonists

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7 January 2021

(4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists

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7 January 2021

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7 January 2021

4-Aminopiperidine ureas as potent selective agonists of the human beta(3)-adrenergic receptor

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7 January 2021

Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties

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7 January 2021

Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists

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7 January 2021

Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

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7 January 2021

Human beta3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Mechanism of amelioration of insulin resistance by beta3-adrenoceptor agonist AJ-9677 in the KK-Ay/Ta diabetic obese mouse model

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7 January 2021

Sustained improvement in glucose homeostasis in lean and obese mice following chronic administration of the beta 3 agonist SR 58611A.

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7 January 2021

Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical beta-adrenoceptors

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7 January 2021

Beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence: 2-[4-(2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl)phenoxy]-2-methylpropionic acid

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7 January 2021

Up-regulation of muscle UCP2 gene expression by a new β3-adrenoceptor agonist, trecadrine, in obese (cafeteria) rodents, but down-regulation in lean animals

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7 January 2021

Effects of the oral administration of a beta3-adrenergic agonist on lipid metabolism in alloxan-diabetic rats

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7 January 2021

Potential anti-diabetic applications of a new molecule with affinity for beta 3-adrenoceptors

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7 January 2021

Aryl propanolamines: comparison of activity at human beta3 receptors, rat beta3 receptors and rat atrial receptors mediating tachycardia

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7 January 2021

L-750355, a human beta3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey

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7 January 2021

10.1016/S0079-6468(02)41005-3

Identifiers

DOI

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6 August 2017

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