(Q35140806)

6 August 2017

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title

Lysosomal cysteine proteases regulate antigen presentation (English)

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6 August 2017

Karen Honey

1

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6 August 2017

Alexander Y Rudensky

series ordinal

2

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6 August 2017

publication date

1 June 2003

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Nature Reviews Immunology

6 August 2017

published in

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6 August 2017

volume

3

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6 August 2017

issue

6

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6 August 2017

page(s)

472-482

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Capture and processing of exogenous antigens for presentation on MHC molecules.

6 August 2017

cites work

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Degradation of cell proteins and the generation of MHC class I-presented peptides

31 March 2020

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MHC class II antigen processing: biology of invariant chain

31 March 2020

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Invariant chain structure and MHC class II function

31 March 2020

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The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

31 March 2020

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T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates

31 March 2020

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Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization

31 March 2020

1 reference

Early endosomes are required for major histocompatiblity complex class II transport to peptide-loading compartments

31 March 2020

1 reference

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

31 March 2020

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Intracellular transport of class II MHC molecules directed by invariant chain.

31 March 2020

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Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments

31 March 2020

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Endosomal aspartic proteinases are required for invariant-chain processing

31 March 2020

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Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading

31 March 2020

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Defective antigen processing in GILT-free mice

31 March 2020

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Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes

31 March 2020

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HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

31 March 2020

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DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide

31 March 2020

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Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface

31 March 2020

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Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells

31 March 2020

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Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane.

31 March 2020

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T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.

31 March 2020

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Proteases involved in MHC class II antigen presentation

31 March 2020

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The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentation

31 March 2020

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A lysosomal protease enters the death scene

31 March 2020

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Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.

31 March 2020

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Thymocyte expression of cathepsin L is essential for NKT cell development

31 March 2020

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The lysosomal cysteine proteases

31 March 2020

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Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase

31 March 2020

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Lysosomal cysteine proteases: facts and opportunities

31 March 2020

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The use of benzyloxycarbonyl[125I]iodotyrosylalanyldiazomethane as a probe for active cysteine proteinases in human tissues

31 March 2020

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Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs

31 March 2020

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Emerging roles for cysteine proteases in human biology

31 March 2020

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Role for intracellular proteases in the processing and transport of class II HLA antigens

31 March 2020

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Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation

31 March 2020

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Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism

31 March 2020

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Cathepsin S activity regulates antigen presentation and immunity

31 March 2020

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Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone.

31 March 2020

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Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus

31 March 2020

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Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice

31 March 2020

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Cathepsin S required for normal MHC class II peptide loading and germinal center development

31 March 2020

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Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.

31 March 2020

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Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes

31 March 2020

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The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (CtsI) gene

31 March 2020

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Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization

31 March 2020

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Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands

31 March 2020

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Cathepsin D, but not cathepsin B, releases T cell stimulatory fragments from lysozyme that are functional in the context of multiple murine class II MHC molecules

31 March 2020

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Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E

31 March 2020

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Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors

31 March 2020

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A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation

31 March 2020

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Specific role for cathepsin S in the generation of antigenic peptides in vivo

31 March 2020

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An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.

31 March 2020

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Control of antigen presentation by a single protease cleavage site

31 March 2020

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Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

31 March 2020

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Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro

31 March 2020

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Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages

31 March 2020

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Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages

31 March 2020

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Interferon gamma induction of pulmonary emphysema in the adult murine lung

31 March 2020

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IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression

31 March 2020

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The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L

31 March 2020

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Purification and characterization of procathepsin L, a self-processing zymogen of guinea pig spermatozoa that acts on a cathepsin D assay substrate

31 March 2020

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Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro

31 March 2020

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Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing

31 March 2020

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Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.

31 March 2020

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MHC Class II Expression Is Regulated in Dendritic Cells Independently of Invariant Chain Degradation

31 March 2020

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Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells

31 March 2020

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Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney

31 March 2020

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Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L

31 March 2020

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Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.

31 March 2020

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Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms

31 March 2020

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Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain

31 March 2020

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The p41 isoform of invariant chain is a chaperone for cathepsin L

31 March 2020

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Invariant chain controls the activity of extracellular cathepsin L.

31 March 2020

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Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation

31 March 2020

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Activation of lysosomal function during dendritic cell maturation

31 March 2020

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Autoreactivity by design: innate B and T lymphocytes

31 March 2020

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The unconventional lifestyle of NKT cells

31 March 2020

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Intracellular pathways of CD1 antigen presentation

31 March 2020

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A subset of CD4+ thymocytes selected by MHC class I molecules

31 March 2020

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NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells.

31 March 2020

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Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove

31 March 2020

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Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol.

31 March 2020

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Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments

31 March 2020

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Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d

31 March 2020

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Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells.

31 March 2020

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Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells.

31 March 2020

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Intracellular trafficking pathway of newly synthesized CD1b molecules

31 March 2020

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Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules

31 March 2020

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CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain

31 March 2020

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Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells

31 March 2020

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Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing

31 March 2020

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Chloroquine affects biosynthesis of Ia molecules by inhibiting dissociation of invariant (gamma) chains from alpha-beta dimers in B cells

31 March 2020

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Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells

31 March 2020

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Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

31 March 2020

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Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

31 March 2020

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Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells

31 March 2020

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Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons

31 March 2020

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Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization

31 March 2020

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Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

31 March 2020

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Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

31 March 2020

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Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation

31 March 2020

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Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1110

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6 August 2017

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