(Q35140840)

6 August 2017

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title

Predicting therapeutic value in the lead optimization phase of drug discovery (English)

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6 August 2017

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Terry Kenakin

1

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6 August 2017

1 June 2003

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Nature Reviews Drug Discovery

6 August 2017

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6 August 2017

2

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6 August 2017

429-438

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6 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrd1110

6 August 2017

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31 March 2020

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31 March 2020

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Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands

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31 March 2020

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31 March 2020

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Synergistic interactions between adenosine A1- and alpha 1B-adrenoceptors in DDT1MF-2 cells

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AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

31 March 2020

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31 March 2020

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Opioids and their complicated receptor complexes

31 March 2020

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Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice

31 March 2020

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Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity

31 March 2020

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Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated G(i).

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Efficient functional coupling of the human D3 dopamine receptor to G(o) subtype of G proteins in SH-SY5Y cells

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling

31 March 2020

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31 March 2020

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The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor.

31 March 2020

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RAMPs: accessory proteins for seven transmembrane domain receptors

31 March 2020

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RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

31 March 2020

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Novel receptor partners and function of receptor activity-modifying proteins

31 March 2020

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Selective up-regulation of 5-HT(1B/1D) receptors during organ culture of cerebral arteries

31 March 2020

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31 March 2020

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Phenotypic changes of adrenomedullin receptor components, RAMP2, and CRLR mRNA expression in cultured rat vascular smooth muscle cells

31 March 2020

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Extracellular matrix regulates smooth muscle responses to substance P

31 March 2020

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Starvation of a clonal osteoblast-like cell line, MOB 3-4-F2, down-regulates prostaglandin E2 receptors but increases cAMP response to prostaglandin E2.

31 March 2020

1 reference

Cell Cycle-dependent Coupling of the Calcitonin Receptor to Different G Proteins

31 March 2020

1 reference

An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3

31 March 2020

1 reference

Proposal for the interaction of non-conventional partial agonists and catecholamines with the 'putative beta 4-adrenoceptor' in mammalian heart

31 March 2020

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The putative beta4-adrenergic receptor is a novel state of the beta1-adrenergic receptor

31 March 2020

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Subtypes of the kappa-opioid receptor: fact or fiction?

31 March 2020

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delta-Opioid receptor subtypes and cross-talk with mu-receptors

31 March 2020

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G-protein-coupled receptor heterodimerization modulates receptor function

31 March 2020

1 reference

Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Spontaneous beta(2)-adrenergic signaling fails to modulate L-type Ca(2+) current in mouse ventricular myocytes

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1110

1 reference

6 August 2017

1 reference

PubMed ID

12776218