(Q35142313)

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Elevated transforming growth factor β and mitogen-activated protein kinase pathways mediate fibrotic traits of Dupuytren's disease fibroblasts

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scholarly article

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Europe PubMed Central

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6 February 2020

Elevated transforming growth factor β and mitogen-activated protein kinase pathways mediate fibrotic traits of Dupuytren's disease fibroblasts (English)

1 reference

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6 February 2020

1

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6 February 2020

Peter Ten Dijke

3

object named as

Peter Ten Dijke

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6 February 2020

author name string

Peter Kloen

2

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6 February 2020

publication date

28 June 2011

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6 February 2020

Fibrogenesis and Tissue Repair

1 reference

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6 February 2020

4

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6 February 2020

1

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6 February 2020

14

1 reference

Europe PubMed Central

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6 February 2020

https://scigraph.springernature.com/pub.10.1186/1755-1536-4-14

0 references

Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3

1 reference

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28 July 2018

Identification of a key residue mediating bone morphogenetic protein (BMP)-6 resistance to noggin inhibition allows for engineered BMPs with superior agonist activity

1 reference

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28 July 2018

ActRIIA and BMPRII Type II BMP receptor subunits selectively required for Smad4-independent BMP7-evoked chemotaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Tyrosine kinase inhibitors for the treatment of fibrotic diseases such as systemic sclerosis: towards molecular targeted therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

BMP-7 as antagonist of organ fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Role of PDGF in fibrotic diseases and systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

The myofibroblast: one function, multiple origins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Formation and function of the myofibroblast during tissue repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Dupuytren disease: Anatomy, pathology, presentation, and treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Non-Smad TGF-beta signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

MAPK/AP-1-dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Enhanced Dupuytren's disease fibroblast populated collagen lattice contraction is independent of endogenous active TGF-beta2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Regulation of PDGF and its receptors in fibrotic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

PDGF receptor kinase inhibitors for the treatment of PDGF driven diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

New insights in the development of Dupuytren's contracture: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Cellular structure and biology of Dupuytren's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Generation of contractile force by cultured Dupuytren's disease and normal palmar fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Abnormal growth factor and cytokine expression in Dupuytren's contracture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Dupuytren's contracture: fibroblast contraction? An ultrastructural study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

28 July 2018

Dupuytren's disease: history, diagnosis, and treatment

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

Myofibroblasts and mechano-regulation of connective tissue remodelling

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

Feedback inhibition of high TGF-beta1 concentrations on myofibroblast induction and contraction by Dupuytren's fibroblasts.

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

Transforming growth factor-beta1 stimulation enhances Dupuytren's fibroblast contraction in response to uniaxial mechanical load within a 3-dimensional collagen gel.

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

The different characteristics of Dupuytren's disease fibroblasts derived from either nodule or cord: expression of alpha-smooth muscle actin and the response to stimulation by TGF-beta1.

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

The contractile properties and responses to tensional loading of Dupuytren's disease--derived fibroblasts are altered: a cause of the contracture?

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

Transforming growth factor beta stimulates fibroblast-collagen matrix contraction by different mechanisms in mechanically loaded and unloaded matrices.

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

27 September 2018

Alpha-smooth muscle actin expression upregulates fibroblast contractile activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3148569

27 September 2018

Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: a novel clue to adverse tissue remodelling?

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-14

21 January 2018

Epidermal growth factor in Dupuytren's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21711521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast

1 reference

https://pubmed.ncbi.nlm.nih.gov/21711521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of transforming growth factor beta in Dupuytren's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21711521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus in the aetiology of Dupuytren's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21711521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta: possible roles in Dupuytren's contracture

1 reference

https://pubmed.ncbi.nlm.nih.gov/21711521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of growth factors in palmar and plantar fibromatoses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21711521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1 reference

https://pubmed.ncbi.nlm.nih.gov/21711521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF beta and bFGF synthesis and localization in Dupuytren's disease (nodular palmar fibromatosis) relative to cellular activity, myofibroblast phenotype and oncofetal variants of fibronectin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21711521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of bone morphogenetic proteins by Dupuytren's fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21711521

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1755-1536-4-14

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21711521%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21711521%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21711521%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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