(Q35143581)

6 August 2017

title

Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii (English)

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6 August 2017

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S B Cohen

1

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6 August 2017

E Y Denkers

series ordinal

2

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6 August 2017

publication date

9 April 2014

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6 August 2017

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6 August 2017

volume

7

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6 August 2017

issue

4

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6 August 2017

page(s)

744-752

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Regulation of intestinal homeostasis by innate and adaptive immunity

6 August 2017

cites work

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The protozoan pathogen Toxoplasma gondii targets the paracellular pathway to invade the intestinal epithelium

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Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence

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Migration of Toxoplasma gondii across biological barriers

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Replication and distribution of Toxoplasma gondii in the small intestine after oral infection with tissue cysts

21 January 2018

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Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread

21 January 2018

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Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis

21 January 2018

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Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection

21 January 2018

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CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain

21 January 2018

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GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii

21 January 2018

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Tightly regulated migratory subversion of immune cells promotes the dissemination of Toxoplasma gondii.

21 January 2018

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https://api.crossref.org/works/10.1038%2FMI.2014.25

Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination.

21 January 2018

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https://api.crossref.org/works/10.1038%2FMI.2014.25

Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

CXCR3-dependent CD4⁺ T cells are required to activate inflammatory monocytes for defense against intestinal infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FMI.2014.25

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FMI.2014.25

Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Gut commensal bacteria direct a protective immune response against Toxoplasma gondii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Toll-like receptor initiated host defense against Toxoplasma gondii

21 January 2018

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Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.

21 January 2018

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https://api.crossref.org/works/10.1038%2FMI.2014.25

Toll-like receptors and their role in host resistance to Toxoplasma gondii

21 January 2018

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https://api.crossref.org/works/10.1038%2FMI.2014.25

Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

UNC93B1 mediates host resistance to infection with Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response.

21 January 2018

1 reference

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Approaching the asymptote? Evolution and revolution in immunology

21 January 2018

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https://api.crossref.org/works/10.1038%2FMI.2014.25

Innate responses to Toxoplasma gondii in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Toxoplasma gondii glycosylphosphatidylinositols up-regulate major histocompatibility complex (MHC) molecule expression on primary murine macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Toxoplasma gondii effectors are master regulators of the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Interleukin 17 receptor signaling is deleterious during Toxoplasma gondii infection in susceptible BL6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Oral infection of C57BL/6 mice with Toxoplasma gondii: a new model of inflammatory bowel disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Paneth cells: maestros of the small intestinal crypts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Reduced Paneth cell alpha-defensins in ileal Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Monocyte recruitment during infection and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Interleukin-15-dependent NKp46+ innate lymphoid cells control intestinal inflammation by recruiting inflammatory monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Monocyte-mediated defense against microbial pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Regulation of immune responses by prostaglandin E2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

The light and dark sides of intestinal intraepithelial lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

CCR5 mediates specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Lamina propria CD4+ T lymphocytes synergize with murine intestinal epithelial cells to enhance proinflammatory response against an intracellular pathogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Intestinal intraepithelial lymphocytes prevent pathogen-driven inflammation and regulate the Smad/T-bet pathway of lamina propria CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Controlling the frontier: regulatory T-cells and intestinal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

NKT cells are critical for the initiation of an inflammatory bowel response against Toxoplasma gondii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2014.25

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection

21 January 2018

1 reference

12 December 2020

Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection.

1 reference

12 December 2020

Murine ileitis after intracellular parasite infection is controlled by TGF-beta-producing intraepithelial lymphocytes

1 reference

12 December 2020

Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines

1 reference

12 December 2020

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

1 reference

12 December 2020

Toxoplasma gondii oral infection induces specific cytotoxic CD8 alpha/beta+ Thy-1+ gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes.

1 reference

12 December 2020

Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice

1 reference

12 December 2020

Mice lacking the chemokine receptor CCR1 show increased susceptibility to Toxoplasma gondii infection

1 reference

12 December 2020

IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii

1 reference

12 December 2020

Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-gamma-independent IL-12

1 reference

12 December 2020

Intraepithelial lymphocytes traffic to the intestine and enhance resistance to Toxoplasma gondii oral infection

1 reference

12 December 2020

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha

1 reference

12 December 2020

Gut-derived intraepithelial lymphocytes induce long term immunity against Toxoplasma gondii

1 reference

12 December 2020

Identifiers

DOI

10.1038/MI.2014.25

1 reference

6 August 2017

1 reference