(Q35143919)

6 August 2017

1 reference

title

TNF-receptor-associated factors as targets for drug development (English)

1 reference

6 August 2017

Juan M Zapata

1

1 reference

PubMed ID

12783577

6 August 2017

language of work or name

English

0 references

publication date

1 June 2003

1 reference

Expert Opinion on Therapeutic Targets

6 August 2017

1 reference

6 August 2017

7

1 reference

6 August 2017

411-425

1 reference

6 August 2017

3

1 reference

The molecular architecture of the TNF superfamily

6 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Signal transduction by tumor necrosis factor and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

The TNF and TNF receptor superfamilies: integrating mammalian biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Immunobiology of tumor necrosis factor receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Apoptosis control by death and decoy receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Toll-like receptors and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Tumor necrosis factor receptor-associated factors (TRAFs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Structurally adaptive hot spots at a protein interaction interface on TRAF3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Expression of the tumor necrosis factor receptor-associated factors (TRAFs) 1 and 2 is a characteristic feature of Hodgkin and Reed-Sternberg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Transcriptional and post-transcriptional control of gene expression in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

CD40 signaling in human dendritic cells is initiated within membrane rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Regulation of TRAF2 signaling by self-induced degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Stress-induced decrease in TRAF2 stability is mediated by Siah2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Both amino- and carboxyl-terminal domains of TRAF3 negatively regulate NF-kappaB activation induced by OX40 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

The apoptotic signaling pathway activated by Toll-like receptor-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Development and maturation of secondary lymphoid tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCE

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TRAF6 is a signal transducer for interleukin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Innate immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Proinflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Structural basis for self-association and receptor recognition of human TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Crystallographic analysis of CD40 recognition and signaling by human TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

The structural basis for the recognition of diverse receptor sequences by TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Molecular basis for CD40 signaling mediated by TRAF3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Downstream regulator TANK binds to the CD40 recognition site on TRAF3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Novel therapies for sepsis: antiendotoxin therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Cardiac inflammation and innate immunity in septic shock: is there a role for toll-like receptors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

RANK-L and RANK: T cells, bone loss, and mammalian evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

CD40 regulates the processing of NF-kappaB2 p100 to p52

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.3.411

21 January 2018

Identifiers

DOI

10.1517/14728222.7.3.411

1 reference

6 August 2017

1 reference

PubMed ID

12783577