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Toll-like receptors and innate immunity
scientific article (publication date: November 2001)
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scholarly article
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review article
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Europe PubMed Central
title
Toll-like receptors and innate immunity
(English)
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
main subject
toll-like receptor
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author
Ruslan Medzhitov
series ordinal
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Medzhitov R
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30 April 2017
language of work or name
English
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30 April 2017
publication date
November 2001
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retrieved
30 April 2017
published in
Nature Reviews Immunology
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
volume
1
1 reference
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PubMed
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retrieved
30 April 2017
page(s)
135-45
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PubMed
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retrieved
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issue
2
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
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CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
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Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
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MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
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Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling
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Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation
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Crossref
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based on heuristic
inferred from DOI database lookup
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2
1 reference
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The molecular mechanism of B cell activation by toll-like receptor protein RP-105
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The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells
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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
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Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
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An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells
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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
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A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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based on heuristic
inferred from DOI database lookup
Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
1 reference
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based on heuristic
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Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
1 reference
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Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
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7 January 2021
based on heuristic
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Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discrimination of bacterial lipoproteins by Toll-like receptor 6
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PKR; a sentinel kinase for cellular stress
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JNK2 and IKKbeta are required for activating the innate response to viral infection
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
1 reference
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https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
A Toll-like receptor recognizes bacterial DNA
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
CpG motifs in bacterial DNA trigger direct B-cell activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transport of bacterial lipopolysaccharide to the golgi apparatus
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Crossref
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https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
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The role of CpG motifs in innate immunity
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reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of direct antimicrobial activity through mammalian toll-like receptors
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Q24291418
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IRAK: a kinase associated with the interleukin-1 receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TRAF6 is a signal transducer for interleukin-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Unresponsiveness of MyD88-deficient mice to endotoxin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Endotoxin-induced maturation of MyD88-deficient dendritic cells
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Crossref
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https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta
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https://api.crossref.org/works/10.1038%2F35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dendritic cells and the control of immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptors control activation of adaptive immune responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pentraxin family of proteins interact specifically with phosphorylcholine and/or phosphorylethanolamine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Scavenger receptors in innate immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/35100529
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
143471
Dimensions Publication ID
1008398067
0 references
OpenCitations bibliographic resource ID
143471
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
143471
PubMed ID
11905821
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
143471
ResearchGate publication ID
11458100
0 references
Springer Nature article ID
10.1038/35100529
0 references
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