(Q35144846)

6 August 2017

title

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV (English)

1 reference

6 August 2017

0 references

Yucheng Xiao

1

1 reference

6 August 2017

James O Jackson

series ordinal

2

1 reference

6 August 2017

Songping Liang

series ordinal

3

1 reference

6 August 2017

Theodore R Cummins

series ordinal

4

1 reference

6 August 2017

language of work or name

English

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publication date

9 June 2011

1 reference

Journal of Biological Chemistry

6 August 2017

published in

1 reference

6 August 2017

volume

286

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6 August 2017

issue

31

1 reference

6 August 2017

page(s)

27301-27310

1 reference

The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

6 August 2017

cites work

1 reference

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Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins

13 July 2018

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Deconstructing voltage sensor function and pharmacology in sodium channels

13 July 2018

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ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.

13 July 2018

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Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration

13 July 2018

1 reference

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Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders

13 July 2018

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13 July 2018

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Closing in on the resting state of the Shaker K(+) channel.

13 July 2018

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The roles of sodium channels in nociception: Implications for mechanisms of pain

13 July 2018

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Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels

13 July 2018

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An SCN9A channelopathy causes congenital inability to experience pain

13 July 2018

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Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.

13 July 2018

1 reference

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13 July 2018

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Beta-scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels.

13 July 2018

1 reference

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

13 July 2018

1 reference

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13 July 2018

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A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom

13 July 2018

1 reference

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Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel.

13 July 2018

1 reference

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Mechanisms of sodium channel inactivation

13 July 2018

1 reference

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Voltage-gated sodium channel toxins: poisons, probes, and future promise

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Neutralization of gating charges in domain II of the sodium channel alpha subunit enhances voltage-sensor trapping by a beta-scorpion toxin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

The human skeletal muscle Na channel mutation R669H associated with hypokalemic periodic paralysis enhances slow inactivation.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Solution structure and functional characterization of jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na+ channels

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149324

Comparative pharmacology and cloning of two novel arachnid sodium channels: Exploring the adaptive insensitivity of scorpion to its toxins

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21659528

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.246876

1 reference

6 August 2017

1 reference

6 August 2017

1 reference