(Q35145016)

English

Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21636575%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth (English)

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2 February 2020

Leishmania mexicana

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Leishmania mexicana

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6

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2 February 2020

Eleanor Saunders

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Eleanor C Saunders

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2 February 2020

author name string

William W Ng

2

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2 February 2020

Jennifer M Chambers

3

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2 February 2020

Milica Ng

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2 February 2020

Thomas Naderer

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2 February 2020

Vladimir A Likic

7

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2 February 2020

Malcolm J McConville

8

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2 February 2020

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2 June 2011

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2 February 2020

Journal of Biological Chemistry

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2 February 2020

286

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2 February 2020

31

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2 February 2020

27706-27717

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2 February 2020

Evidence that intracellular stages of Leishmania major utilize amino sugars as a major carbon source

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Ablation of succinate production from glucose metabolism in the procyclic trypanosomes induces metabolic switches to the glycerol 3-phosphate/dihydroxyacetone phosphate shuttle and to proline metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Branched tricarboxylic acid metabolism in Plasmodium falciparum

1 reference

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28 July 2018

Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Carbon metabolism of intracellular bacterial pathogens and possible links to virulence

1 reference

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28 July 2018

Central carbon metabolism of Leishmania parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Surprising variety in energy metabolism within Trypanosomatidae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)

1 reference

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28 July 2018

Carbon metabolism of Listeria monocytogenes growing inside macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Metabolism of Leishmania: proven and predicted

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Metabolic functions of glycosomes in trypanosomatids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Fumarate is an essential intermediary metabolite produced by the procyclic Trypanosoma brucei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Leishmania beta-1,2-mannan is assembled on a mannose-cyclic phosphate primer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Energy metabolism of trypanosomatids: adaptation to available carbon sources

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Drug resistance in leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Advances in leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

ATP generation in the Trypanosoma brucei procyclic form: cytosolic substrate level is essential, but not oxidative phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Genetic characterization of glucose transporter function in Leishmania mexicana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Characterisation of phosphoglycerate kinase genes in Leishmania major and evidence for the absence of a third closely related gene or isoenzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Adaptation of metabolic enzyme activities of Trypanosoma brucei promastigotes to growth rate and carbon regimen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Mortality of Leishmania major in Phlebotomus papatasi caused by plant feeding of the sand flies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Studies on the amino acids of the tsetse fly, Glossina morsitans, maintained on in vitro and in vivo feeding systems.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

End products and enzyme levels of aerobic glucose fermentation in trypanosomatids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Compartmentation of carbohydrate metabolism in trypanosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

A carbon-13 nuclear magnetic resonance analysis of the products of glucose metabolism in Leishmania pifanoi amastigotes and promastigotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Molecular analysis of the cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase in Leishmania mexicana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

28 July 2018

Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Isotopologue profiling of Legionella pneumophila: role of serine and glucose as carbon substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

LeishCyc: a biochemical pathways database for Leishmania major.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

(13)C-based metabolic flux analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Functional characterization of stage-specific aminotransferases from trypanosomatids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Active transport of glutamate in Leishmania (Leishmania) amazonensis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Role of hexosamine biosynthesis in Leishmania growth and virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Purine and pyrimidine metabolism in Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Progressive peak clustering in GC-MS Metabolomic experiments applied to Leishmania parasites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Acetyl:succinate CoA-transferase in procyclic Trypanosoma brucei. Gene identification and role in carbohydrate metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Pentose phosphate metabolism in Leishmania mexicana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Developmental regulation of proline transport in Leishmania donovani.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Organization, sequence and stage-specific expression of the phosphoglycerate kinase genes of Leishmania mexicana mexicana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3149361

27 September 2018

Leishmania mexicana: Subcellular distribution of enzymes in amastigotes and promastigotes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.213553

21 January 2018

Leishmania mexicana: energy metabolism of amastigotes and promastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21636575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of individual purine and pyrimidine nucleoside di- and triphosphates and other cellular metabolites in PCA extracts by using multinuclear high resolution NMR spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21636575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the respiratory chain results in a reversible metabolic arrest in Leishmania promastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21636575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and partial characterization of a broad specificity aminotransferase from Leishmania mexicana promastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21636575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leishmania spp: completely defined medium without serum and macromolecules (CDM/LP) for the continuous in vitro cultivation of infective promastigote forms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21636575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M110.213553

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21636575%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21636575%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21636575%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

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