(Q35145907)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

2

1 reference

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25 February 2020

Chris S Pridgeon

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Sean Harrison

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Neil A. Hanley

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

David Tosh

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

14

Melanie J Welham

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

author name string

Richard Kia

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Rowena L C Sison-Young

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Fang Zhang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

James A Heslop

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Pete Metcalfe

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Neil R Kitteringham

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Melissa Baxter

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Zoë D Burke

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Mike P Storm

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Barbara Küppers-Munther

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Josefina Edsbagge

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Philip J Starkey Lewis

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Frank Bonner

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Ernie Harpur

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

James Sidaway

21

1 reference

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25 February 2020

Joanne Bowes

22

1 reference

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25 February 2020

Stephen W Fenwick

23

1 reference

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25 February 2020

Hassan Malik

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

Chris E P Goldring

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

B Kevin Park

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

language of work or name

English

0 references

publication date

18 December 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

published in

Toxicological Sciences

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

volume

144

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

page(s)

173-185

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

25 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Pluripotent stem cell derived hepatocyte like cells and their potential in toxicity screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Analysis of the distinct functions of growth factors and tissue culture substrates necessary for the long-term self-renewal of human embryonic stem cell lines

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Differentiation of mouse and human embryonic stem cells into hepatic lineages.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

The evolution of gene regulation by transcription factors and microRNAs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

High content cellular screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Identification of tissue-specific microRNAs from mouse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Cytotoxicity tests for high-throughput drug discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

28 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Comparison of cell proliferation and toxicity assays using two cationic liposomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Identification of miRNAs in a liver of a human fetus by a modified method.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Public perceptions of the pharmaceutical industry and drug safety: implications for the pharmacovigilance professional and the culture of safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Vascularized and functional human liver from an iPSC-derived organ bud transplant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Circulating microRNAs, potential biomarkers for drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFU269

Bioactivation and toxicity of acetaminophen in a rat hepatocyte micropatterned coculture system

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349141

3-D coculture of hepatic sinusoidal cells with primary hepatocytes-design of an organotypical model

27 September 2018

1 reference

12 December 2020

Isolation and culture of primary human hepatocytes

1 reference

12 December 2020

Circulating microRNAs as potential markers of human drug-induced liver injury

1 reference

12 December 2020

Expression profiles of miRNAs in human embryonic stem cells during hepatocyte differentiation

1 reference

12 December 2020

Identifiers

DOI

10.1093/TOXSCI/KFU269

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25527335%20AND%20SRC:MED&resulttype=core&format=json