(Q35147546)

6 August 2017

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title

Model ion channels: gramicidin and alamethicin (English)

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6 August 2017

B A Wallace

2

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ORCID Public Data File 2021

author name string

G A Woolley

series ordinal

1

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6 August 2017

publication date

1 August 1992

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6 August 2017

number of pages

28

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Journal of Membrane Biology

inferred from page(s)

published in

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6 August 2017

volume

129

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6 August 2017

issue

2

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6 August 2017

page(s)

109-136

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Lipid dependence of peptide-membrane interactions. Bilayer affinity and aggregation of the peptide alamethicin

6 August 2017

cites work

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12 December 2020

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

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12 December 2020

Deuterium NMR of Val1...(2-2H)Ala3...gramicidin A in oriented DMPC bilayers

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12 December 2020

Circular dichroism studies of helical oligopeptides. Can 3(10) and alpha-helical conformations be chiroptically distinguished?

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12 December 2020

Ion-bond forms of the gramicidin a transmembrane channel

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12 December 2020

Synthetic amphiphilic peptide models for protein ion channels

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12 December 2020

Ion channel subconductance states

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12 December 2020

Action potentials induced in biomolecular lipid membranes

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12 December 2020

Experimental and theoretical study of gramicidin P, an analog of gramicidin A with a methylamine C-terminal

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12 December 2020

Potassium channels in myelinated nerve. Selective permeability to small cations

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12 December 2020

Lipid phase transition in planar bilayer membrane and its effect on carrier- and pore-mediated ion transport

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12 December 2020

Kinetics and stability of alamethicin conducting channels in lipid bilayers.

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12 December 2020

Distinction between dipolar and inductive effects in modulating the conductance of gramicidin channels

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12 December 2020

Conformational Changes of Alamethicin Induced by Solvent and Temperature. A 13C-NMR and Circular-Dichroism Study

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12 December 2020

Trichotoxin A40. Purification by counter-current distribution and sequencing of isolated fragments

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12 December 2020

Voltage-dependent conductance for alamethicin in phospholipid vesicles. A test for the mechanism of gating

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12 December 2020

Proline residues in transmembrane helices: structural or dynamic role?

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12 December 2020

Dipoles of the α-helix and β-sheet: their role in protein folding

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12 December 2020

Conformation of peptide chains containing both L- & D-residues. I. Helical structures with alternating L- & D-residues with special reference to the LD-ribbon & the LD-helices

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12 December 2020

Single-channel parameters of gramicidin a,b, and c

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12 December 2020

Principles that determine the structure of proteins

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12 December 2020

The Detection of Ionophorous Antibiotic-Cation Complexes in Water with Fluorescent Probes

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12 December 2020

The kinetics of ion movements in the gramicidin channel

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12 December 2020

Structural parts involved in activation and inactivation of the sodium channel

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12 December 2020

Simultaneous fluorescence and conductance studies of planar bilayer membranes containing a highly active and fluorescent analog of gramicidin A.

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12 December 2020

Factors governing helical preference of peptides containing multiple alpha,alpha-dialkyl amino acids

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12 December 2020

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence

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12 December 2020

Comparison of the conformation and orientation of alamethicin and melittin in lipid membranes

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12 December 2020

Voltage-dependent channels in planar lipid bilayer membranes

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12 December 2020

Distribution of alamethicin in lipid membranes and water

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12 December 2020

Influence of membrane thickness and ion concentration on the properties of the gramicidin a channel. Autocorrelation, spectral power density, relaxation and single-channel studies

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12 December 2020

Deformation free energy of bilayer membrane and its effect on gramicidin channel lifetime

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12 December 2020

Mixtures of gramicidin and lysophosphatidylcholine form lamellar structures

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12 December 2020

Conserved positioning of proline residues in membrane-spanning helices of ion-channel proteins

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12 December 2020

Three-dimensional structure at 0.86 A of the uncomplexed form of the transmembrane ion channel peptide gramicidin A

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12 December 2020

Helix aggregation in peptide crystals: occurrence of either all parallel or antiparallel packing motifs for alpha-helices in polymorphs of Boc-Aib-Ala-Leu-Ala-Leu-Aib-Leu-Ala-Leu-Aib-OMe

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12 December 2020

Crystal structure of [Leu1]zervamicin, a membrane ion-channel peptide: implications for gating mechanisms

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12 December 2020

"Reversed" alamethicin conductance in lipid bilayers

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12 December 2020

Method of oriented circular dichroism

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12 December 2020

Is the gramicidin a transmembrane channel single-stranded or double-stranded helix? A simple unequivocal determination

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12 December 2020

Voltage-induced thickness changes of lipid bilayer membranes and the effect of an electrin field on gramicidin A channel formation

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12 December 2020

Time-correlation analysis of simulated water motion in flexible and rigid gramicidin channels

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12 December 2020

Transmembrane channels based on tartaric acid-gramicidin A hybrids

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12 December 2020

Melittin and a chemically modified trichotoxin form alamethicin-type multi-state pores

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12 December 2020

Studies of the conductance changes induced in bimolecular lipid membranes by alamethicin

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12 December 2020

Purification of gramicidin A

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12 December 2020

Destabilization of an alpha-helix-bundle protein by helix dipoles

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12 December 2020

Ion movement through gramicidin A channels. Single-channel measurements at very high potentials

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12 December 2020

The lowest conductance state of the alamethicin pore

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12 December 2020

Raman-spectroscopic evidence for the incorporation of alamethicin into dimyristoylphosphatidylcholine bilayers

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12 December 2020

Temperature-jump and voltage-jump experiments at planar lipid membranes support an aggregational (micellar) model of the gramicidin A ion channel

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12 December 2020

The divalent cation-binding sites of gramicidin A transmembrane ion-channel

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12 December 2020

Induction of conductance heterogeneity in gramicidin channels

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12 December 2020

Nature's rules and chemist's tools: a way for creating novel proteins

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12 December 2020

Intermolecular interactions of gramicidin A′ transmembrane channels incorporated into lysophosphatidylcholine lipid systems

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12 December 2020

Supramolecular organization of lysophosphatidylcholine-packaged gramicidin A′

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12 December 2020

Conformational transitions of gramicidin A in phospholipid model membranes. A high-performance liquid chromatography assessment

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12 December 2020

Pure lipid vesicles can induce channel-like conductances in planar bilayers

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12 December 2020

Autocatalytic transport of the peptide antibiotics suzukacillin and alamethicin across lipid membranes

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12 December 2020

Membrane excitation through voltage-induced aggregation of channel precursors

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12 December 2020

Amino acid sequence modulation of gramicidin channel function: effects of tryptophan-to-phenylalanine substitutions on the single-channel conductance and duration

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12 December 2020

Interaction of nonylguanidine with the sodium channel

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12 December 2020

The source of the dispersity of gramicidin A single-channel conductances. The L X Leu5-gramicidin A analog

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12 December 2020

Electrostatic modeling of dipole-ion interactions in gramicidinlike channels

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12 December 2020

Biosynthesis of peptide antibiotics

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12 December 2020

Freezing and Melting of Lipid Bilayers and the Mode of Action of Nonactin, Valinomycin, and Gramicidin

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12 December 2020

Conformation of alamethicin in phospholipid vesicles: implications for insertion models.

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12 December 2020

Location and dynamics of alamethicin in unilamellar vesicles and thylakoids as model systems. A spin label study

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12 December 2020

Alamethicin-mediated fusion of lecithin vesicles

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12 December 2020

Small iminium ions block gramicidin channels in lipid bilayers

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12 December 2020

Brief closures of gramicidin A channels in lipid bilayer membranes

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12 December 2020

Conformations of proline residues in membrane environments

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12 December 2020

Determination of the structure of a membrane-incorporated ion channel. Solid-state nuclear magnetic resonance studies of gramicidin A

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12 December 2020

Conformation of the gramicidin A transmembrane channel: A 13C nuclear magnetic resonance study of 13C-enriched gramicidin in phosphatidylcholine vesicles

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12 December 2020

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12 December 2020

The normal modes of the gramicidin-A dimer channel

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12 December 2020

Conformation of gramicidin A in phospholipid vesicles: circular dichroism studies of effects of ion binding, chemical modification, and lipid structure

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12 December 2020

Solid phase peptide synthesis of 15N-gramicidins A, B, and C and high performance liquid chromatographic purification

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12 December 2020

Influence of cholesterol on gramicidin-induced HII phase formation in phosphatidylcholine model membranes

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12 December 2020

Structure of Alamethicin in solution. One- and two-dimensional 1H nuclear magnetic resonance studies at 500 MHz.

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12 December 2020

The conformation of alamethicin

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12 December 2020

A molecular model of membrane excitability

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12 December 2020

Why is gramicidin valence selective? A theoretical study

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12 December 2020

Solid-state nuclear magnetic resonance derived model for dynamics in the polypeptide backbone of the gramicidin a channel

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12 December 2020

Voltage-dependent lipid flip-flop induced by alamethicin

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12 December 2020

Dipole moment of alamethicin as related to voltage-dependent conductance in lipid bilayers

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12 December 2020

Conformationally constrained ?-helical peptide models for protein ion channels

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12 December 2020

The effects of viscosity on gramicidin tryptophan rotational motion

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12 December 2020

Gramicidin A--phospholipid model systems

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12 December 2020

Thermodynamic analysis of incorporation and aggregation in a membrane: application to the pore-forming peptide alamethicin.

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12 December 2020

Gramicidin forms multi-state rectifying channels

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12 December 2020

A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-Å resolution

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12 December 2020

Structural and dipolar properties of the voltage-dependent pore former alamethicin in octanol/dioxane

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12 December 2020

Leakage of internal markers from erythrocytes and lipid vesicles induced by melittin, gramicidin S and alamethicin: a comparative study

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12 December 2020

Electrostatic modeling of ion pores. II. Effects attributable to the membrane dipole potential

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12 December 2020

Structure of alamethicin in solution: nuclear magnetic resonance relaxation studies

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12 December 2020

Chemical nature and sequence of alamethicin

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12 December 2020

Calculation of deformation energies and conformations in lipid membranes containing gramicidin channels

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12 December 2020

Simple model of ion transport through alamethicin channels in lipid membranes.

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12 December 2020

Alamethicin adsorption to a planar lipid bilayer

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12 December 2020

Semisynthesis of linear gramicidins using diphenyl phosphorazidate (DPPA)

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12 December 2020

Ionic selectivity revisited: The role of kinetic and equilibrium processes in ion permeation through channels

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12 December 2020

The membrane as an environment of minimal interconversion. A circular dichroism study on the solvent dependence of the conformational behavior of gramicidin in diacylphosphatidylcholine model membranes

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12 December 2020

Voltage-dependent pore activity of the peptide alamethicin correlated with incorporation in the membrane: salt and cholesterol effects

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12 December 2020

Single-channel studies on linear gramicidins with altered amino acid side chains. Effects of altering the polarity of the side chain at position 1 in gramicidin A

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12 December 2020

Molecular mechanisms of alamethicin channel gating

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12 December 2020

The primary structure of alamethicin

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12 December 2020

GRAMICIDIN A. VI. THE SYNTHESIS OF VALINE- AND ISOLEUCINE-GRAMICIDIN A

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12 December 2020

Gramicidin Channels and Pores

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12 December 2020

Alamethicin. A rich model for channel behavior

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12 December 2020

Modulation of alamethicin-induced conductance by membrane composition

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12 December 2020

Transmembrane channel activity of gramicidin A analogs: Effects of modification and deletion of the amino-terminal residue

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12 December 2020

Alamethicin-induced current-voltage curve asymmetry in lipid bilayers

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12 December 2020

Design and conformation of non-Aib synthetic peptides enjoying alamethicin-like ionophore activity

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12 December 2020

The different influences of ether and ester phospholipids on the conformation of gramicidin A. A molecular modelling study

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12 December 2020

A lipid vesicle system for probing voltage-dependent peptide-lipid interactions: application to alamethicin channel formation

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12 December 2020

Ion-water and ion-polypeptide correlations in a gramicidin-like channel. A molecular dynamics study

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12 December 2020

Dynamics and aggregation of the peptide ion channel alamethicin. Measurements using spin-labeled peptides

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12 December 2020

Electric field dependence of alamethicin channels

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12 December 2020

Co-crystals of gramicidin A and phospholipid. A system for studying the structure of a transmembrane channel

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12 December 2020

Statistical analysis of alamethicin channels in black lipid membranes

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12 December 2020

The effect of microwave radiation on the stability and formation of gramicidin-A channels in lipid bilayer membranes

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12 December 2020

High-resolution 1H NMR study of the solution structure of alamethicin

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12 December 2020

GRAMICIDIN. VII. THE STRUCTURE OF VALINE- AND ISOLEUCINE-GRAMICIDIN B

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12 December 2020

Gramicidins A, B, and C form structurally equivalent ion channels.

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12 December 2020

Structure of the gramicidin A channel: Discrimination between the π L,D and the β helix by electrical measurements with lipid bilayer membranes

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12 December 2020

A three state model for alamethicin conductance in bilayer membranes

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12 December 2020

Local anaesthetics transiently block currents through single acetylcholine-receptor channels

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12 December 2020

The effects of bilayer thickness and tension on gramicidin single-channel lifetime

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12 December 2020

Temperature dependence of single channel currents and the peptide libration mechanism for ion transport through the gramicidin A transmembrane channel.

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12 December 2020

The polypeptide 310-helix

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12 December 2020

Gramicidin cation channel: an experimental determination of the right-handed helix sense and verification of beta-type hydrogen bonding

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12 December 2020

Some properties of the ion-gating polypeptide alamethicin

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12 December 2020

Deuterium NMR of 2HCO-Val1...gramicidin A and 2HCO-Val1-D-Leu2...gramicidin A in oriented DMPC bilayers

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12 December 2020

Conformation and orientation of gramicidin a in oriented phospholipid bilayers measured by solid state carbon-13 NMR.

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12 December 2020

TI-205 nuclear magnetic resonance determination of the thermodynamic parameters for the binding of monovalent cations to gramicidins A and C

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12 December 2020

Photo-modulated ion channels based on covalently linked gramicidins

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12 December 2020

Alamethicin incorporation in lipid bilayers: a thermodynamic study

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12 December 2020

The use of single-wavelength anomalous scattering to solve the crystal structure of a gramicidin A/caesium chloride complex

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12 December 2020

Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution

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12 December 2020

Molecular anatomy and molecular design of channel proteins

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12 December 2020

2H nuclear magnetic resonance of the gramicidin A backbone in a phospholipid bilayer

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12 December 2020

Distribution of phospholipids around gramicidin and D-beta-hydroxybutyrate dehydrogenase as measured by resonance energy transfer

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12 December 2020

Channel protein engineering: synthetic 22-mer peptide from the primary structure of the voltage-sensitive sodium channel forms ionic channels in lipid bilayers

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12 December 2020

Voltage-induced formation of alamethicin pores in lecithin bilayer vesicles

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12 December 2020

Evaluation of surface tension and ion occupancy effects on gramicidin A channel lifetime

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12 December 2020

Proline kinks in transmembrane alpha-helices

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12 December 2020

A quantitative description of membrane current and its application to conduction and excitation in nerve

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12 December 2020

The gramicidin pore: crystal structure of a cesium complex

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12 December 2020

The gramicidin A transmembrane channel: a proposed pi(L,D) helix

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12 December 2020

Model membranes and excitability

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12 December 2020

Structure of gramicidin A.

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12 December 2020

The appearance of single-ion channels in unmodified lipid bilayer membranes at the phase transition temperature

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12 December 2020

The biophysics of peptide models of ion channels

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12 December 2020

Gramicidin single-channel properties show no solvent-history dependence

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12 December 2020

Energy profiles in the gramicidin A channel

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12 December 2020

Tryptophan photolysis is responsible for gramicidin-channel inactivation by ultraviolet light

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12 December 2020

Pore formation in lipid membranes by alamethicin

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12 December 2020

Interaction of alamethicin with lecithin bilayers: a 31P and 2H NMR study

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12 December 2020

Cation selectivity of the resting membrane of squid axon

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12 December 2020

Physico-chemical Basis of Ion Transport through Biological Membranes: Ionophores and Ion Channels

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12 December 2020

Time-variant conductance of bilayer membranes treated with monazomycin and alamethicin

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12 December 2020

Alamethicin-induced changes in lipid bilayer morphology

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12 December 2020

GRAMICIDIN A. V. THE STRUCTURE OF VALINE- AND ISOLEUCINE-GRAMICIDIN A

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12 December 2020

Cytolytic pore-forming proteins and peptides: is there a common structural motif?

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12 December 2020

The conformation of gramicidin A

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12 December 2020

Temperature-dependent properties of gramicidin A channels

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12 December 2020

Fourier transform infrared spectra of the polypeptide alamethicin and a possible structural similarity with bacteriorhodopsin

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12 December 2020

1H-NMR study of gramicidin A transmembrane ion channel. Head-to-head right-handed, single-stranded helices

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12 December 2020

Membrane protein folding and oligomerization: the two-stage model

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12 December 2020

Incorporation kinetics in a membrane, studied with the pore-forming peptide alamethicin

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12 December 2020

Energetics of gramicidin hybrid channel formation as a test for structural equivalence. Side-chain substitutions in the native sequence.

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12 December 2020

The action of a carbonsuboxide dimerized gramicidin A on lipid bilayer membranes

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12 December 2020

On the conductance heterogeneity in membrane channels formed by gramicidin A. A cooperative study

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12 December 2020

The Gramicidin A Transmembrane Channel: Characteristics of Head-to-Head Dimerized π (L,D) Helices

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12 December 2020

Proton conductance by the gramicidin water wire. Model for proton conductance in the F1F0 ATPases?

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12 December 2020

Bundles of amphipathic transmembrane alpha-helices as a structural motif for ion-conducting channel proteins: studies on sodium channels and acetylcholine receptors

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12 December 2020

Ion interactions in (1-13C)d-Val8 andd-Leu14 analogs of gramicidin A, the helix sense of the channel and location of ion binding sites

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12 December 2020

Interaction of ions and water in gramicidin A channels: streaming potentials across lipid bilayer membranes

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12 December 2020

Conformational studies on the gramicidin A transmembrane channel in lipid micelles and liposomes

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12 December 2020

Permeation characteristics of gramicidin conformers

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12 December 2020

A quantitative infrared determination of acyl chain conformation in Gramicidin/dipalmitoylphosphatidylcholine mixtures

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12 December 2020

Interactions of helical polypepetide segments which span the hydrocarbon region of lipid bilayers. Studies of the gramicidin A lipid-water system

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12 December 2020

Investigation of the interaction between thallous ions and gramicidin A in dimyristoylphosphatidylcholine vesicles: a thallium-205 NMR equilibrium study

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12 December 2020

Low conductance gramicidin A channels are head-to-head dimers of beta 6.3-helices

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12 December 2020

The nature of the voltage-dependent conductance induced by alamethicin in black lipid membranes

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12 December 2020

Pressure effects on alamethicin conductance in bilayer membranes

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12 December 2020

Synthesis and characterization of 1-(13) C-D X Leu12, 14 gramicidin A

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12 December 2020

Binding of thallium and other cations to the gramicidin A channel. Equilibrium dialysis study of gramicidin in phosphatidylcholine vesicles

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12 December 2020

Tryptophan interactions of gramicidin A' channels in lipids: a time-resolved fluorescence study

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12 December 2020

Single-channel studies on linear gramicidins with altered amino acid sequences. A comparison of phenylalanine, tryptophane, and tyrosine substitutions at positions 1 and 11

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12 December 2020

Ion transfer across lipid membranes in the presence of gramicidin A. II. The ion selectivity.

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12 December 2020

Location of ion-binding sites in the gramicidin channel by X-ray diffraction

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12 December 2020

The dimeric nature of the gramicidin A transmembrane channel: conductance and fluorescence energy transfer studies of hybrid channels

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12 December 2020

Pore formation kinetics in membranes, determined from the release of marker molecules out of liposomes or cells

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12 December 2020

Solvent history dependence of gramicidin A conformations in hydrated lipid bilayers

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12 December 2020

Is there a common design for cell membrane channels?

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12 December 2020

The gramicidin a channel: A review of its permeability characteristics with special reference to the single-file aspect of transport

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12 December 2020

Conformation and pairing properties of the N-terminal fragments of trichorzianine and alamethicin: a theoretical study

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12 December 2020

Pursuing the structure and function of voltage-gated channels

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12 December 2020

Gramicidin-induced enhancement of transbilayer reorientation of lipids in the erythrocyte membrane

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12 December 2020

N -Acetyl Gramicidin: Single-Channel Properties and Implications for Channel Structure

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12 December 2020

Lateral diffusion of gramicidin C in phospholipid multibilayers. Effects of cholesterol and high gramicidin concentration

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12 December 2020

Monoclinic uncomplexed double-stranded, antiparallel, left-handed beta 5.6-helix (increases decreases beta 5.6) structure of gramicidin A: alternate patterns of helical association and deformation

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12 December 2020

Experimental determination of torsion angles in the polypeptide backbone of the gramicidin a channel by solid state nuclear magnetic resonance

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12 December 2020

Number of water molecules coupled to the transport of sodium, potassium and hydrogen ions via gramicidin, nonactin or valinomycin

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12 December 2020

Paracelsin; characterization by NMR spectroscopy and circular dichroism, and hemolytic properties of a peptaibol antibiotic from the cellulolytically active mold Trichoderma reesei. Part B

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12 December 2020

Vibrational analysis of the structure of gramicidin A. II. Vibrational spectra

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12 December 2020

Ion transport in a model gramicidin channel. Structure and thermodynamics

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12 December 2020

Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore

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12 December 2020

Fluorometric analysis of transferable membrane pores.

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12 December 2020

Stereochemical considerations for constructing alpha-helical protein bundles with particular application to membrane proteins

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12 December 2020

Toward a molecular understanding of excitability. Alamethicin in black lipid films

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12 December 2020

Synthesis and characterization of (1 - 13C) Phe9 gramicidin A. Effects of side chain variations

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12 December 2020

Conformation of the gramicidin A channel in phospholipid vesicles: a fluorine-19 nuclear magnetic resonance study

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12 December 2020

Alamethicin-induced single channel conductance fluctuations in biological membranes

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12 December 2020

The structure of gramicidin A in dimethylsulfoxide/acetone

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12 December 2020

The antibacterial activity of alamethicins and zervamicins

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12 December 2020

Synthetic analogues of alamethicin: Effect of C-terminal residue substitutions and chain length on the ion channel lifetimes

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12 December 2020

Effect of anions on the cation selectivity of gramicidin-containing liposomes

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12 December 2020

Solid-state 13C-NMR studies of the effects of sodium ions on the gramicidin A ion channel

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12 December 2020

Synporins--synthetic proteins that emulate the pore structure of biological ionic channels

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12 December 2020

The aggregation of gramicidin A in solution.

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12 December 2020

Potential-dependent conductances in lipid membranes containing alamethicin

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12 December 2020

Effects of surface charge on the conductance of the gramicidin channel

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12 December 2020

Asymmetry of the gramicidin channel in bilayers of asymmetric lipid composition: II. Voltage dependence of dimerization

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12 December 2020

Charge-pulse relaxation studies with lipid bilayer membranes modified by alamethicin

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12 December 2020

Nuclear magnetic resonance studies of the polypeptide alamethicin and its interaction with phospholipids.

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12 December 2020

Cholesterol-dependent gramicidin A channel inactivation in red blood cell membranes and lipid bilayer membranes

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12 December 2020

Dynamic properties of gramicidin A in phospholipid membranes

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12 December 2020

Structural characteristics of alpha-helical peptide molecules containing Aib residues

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12 December 2020

Ion transfer across lipid membranes in the presence of gramicidin A. I. Studies of the unit conductance channel

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12 December 2020

Voltage-dependent and multi-state ionic channels induced by trichorzianines, anti-fungal peptides related to alamethicin

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12 December 2020

HPLC study on the 'history' dependence of gramicidin A conformation in phospholipid model membranes

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12 December 2020

Modulation of gramicidin A open channel lifetime by ion occupancy

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12 December 2020

Membrane modifying activity of four peptide components of antiamoebin, a microheterogeneous fungal antibiotic

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12 December 2020

The aggregation of alamethicin

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12 December 2020

A difference infrared spectroscopic study of gramicidin a, alamethicin and bacteriorhodopsin in perdeuterated dimyristoylphosphatidylcholine

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12 December 2020

Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5Å resolution: using amino acid sequence data

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12 December 2020

Structure and function of channels and channelogs as studied by computational chemistry

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12 December 2020

Transmembrane distribution of gramicidin by tryptophan energy transfer

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12 December 2020

Structural and membrane modifying porperties of suzukacillin, a peptide antibiotic related to alamethicin. Part B. Pore formation in black lipid films

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12 December 2020

Conformation of gramicidin A channel in phospholipid vesicles: a 13C and 19F nuclear magnetic resonance study

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12 December 2020

Identifiers

DOI

10.1007/BF00219508

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6 August 2017

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