(Q35149624)

6 August 2017

title

Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome (English)

1 reference

6 August 2017

Jared J Barrott

1

1 reference

6 August 2017

Gabriela M Cash

2

1 reference

6 August 2017

Aaron P Smith

3

1 reference

6 August 2017

Jeffery R Barrow

4

1 reference

6 August 2017

L Charles Murtaugh

5

1 reference

6 August 2017

language of work or name

English

0 references

publication date

18 July 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

published in

1 reference

6 August 2017

volume

108

1 reference

6 August 2017

issue

31

1 reference

6 August 2017

page(s)

12752-12757

1 reference

Wnt signaling regulates mitochondrial physiology and insulin sensitivity

6 August 2017

cites work

1 reference

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13 July 2018

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Lentiviral vectors to probe and manipulate the Wnt signaling pathway

13 July 2018

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13 July 2018

1 reference

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Wnt signaling in skin organogenesis

13 July 2018

1 reference

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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

13 July 2018

1 reference

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Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development

13 July 2018

1 reference

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Wnt signaling mediates self-organization and axis formation in embryoid bodies

13 July 2018

1 reference

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Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice

13 July 2018

1 reference

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beta-Catenin has sequential roles in the survival and specification of ventral dermis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog

13 July 2018

1 reference

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Ghrelin octanoylation mediated by an orphan lipid transferase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Lipid-independent secretion of a Drosophila Wnt protein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Mutations in X-linked PORCN, a putative regulator of Wnt signaling, cause focal dermal hypoplasia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Helping Wingless take flight: how WNT proteins are secreted

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

The Wnt signaling pathway in development and disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Convergence of Wnt, beta-catenin, and cadherin pathways

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Wnt proteins are lipid-modified and can act as stem cell growth factors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

A highly efficient recombineering-based method for generating conditional knockout mutations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Probable identity of Goltz syndrome and Van Allen-Myhre syndrome: evidence from phenotypic evolution

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

WNT signals are required for the initiation of hair follicle development

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Requirement for Wnt3 in vertebrate axis formation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Cytogenetic and molecular evidence for cutaneous mosaicism: the ectodermal origin of Blaschko lines

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Transformation by Wnt family proteins correlates with regulation of beta-catenin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Lack of beta-catenin affects mouse development at gastrulation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Phase separation of integral membrane proteins in Triton X-114 solution

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Focal dermal hypoplasia (Goltz syndrome).

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

PORCN mutations in focal dermal hypoplasia: coping with lethality

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Deficiency of PORCN, a regulator of Wnt signaling, is associated with focal dermal hypoplasia.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3150921

Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancer

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21768372

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1006437108

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference