(Q35150167)

6 August 2017

title

Purkinje cell degeneration in pcd mice reveals large scale chromatin reorganization and gene silencing linked to defective DNA repair (English)

1 reference

6 August 2017

0 references

1 reference

2

Iñigo Casafont

1 reference

6 August 2017

Fernando C Baltanás

1

1 reference

6 August 2017

Vanesa Lafarga

3

1 reference

6 August 2017

Eduardo Weruaga

4

1 reference

6 August 2017

José R Alonso

5

1 reference

6 August 2017

María T Berciano

6

1 reference

6 August 2017

Miguel Lafarga

7

1 reference

6 August 2017

language of work or name

English

0 references

publication date

23 June 2011

1 reference

Journal of Biological Chemistry

6 August 2017

published in

1 reference

6 August 2017

volume

286

1 reference

6 August 2017

issue

32

1 reference

6 August 2017

page(s)

28287-28302

1 reference

describes a project that uses

6 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3151073/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Telomeres: protecting chromosomes against genome instability

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

CCP1/Nna1 functions in protein turnover in mouse brain: Implications for cell death in Purkinje cell degeneration mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Loss of A-type lamins and genomic instability

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Cajal's contribution to the knowledge of the neuronal cell nucleus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

The emerging role of nuclear architecture in DNA repair and genome maintenance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Chromatin and nuclear architecture in the nervous system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Apoptosis: controlled demolition at the cellular level

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Defective DNA repair and neurodegenerative disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

DNA damage responses in neural cells: Focus on the telomere

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

The Purkinje cell degeneration (pcd) mouse: an unexpected molecular link between neuronal degeneration and regeneration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Purkinje cell death: differences between developmental cell death and neurodegenerative death in mutant mice.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

The aging brain: accumulation of DNA damage or neuron loss?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Molecular basis of programmed cell death involved in neurodegeneration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Breaks in coordination: DNA repair in inherited ataxia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

DNA end joining activity is reduced in Alzheimer's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

The function of nuclear architecture: a genetic approach

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

H2AX: the histone guardian of the genome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

DNA single-strand breaks and neurodegeneration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Visualizing telomere dynamics in living mammalian cells using PNA probes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Histone lysine methylation: a signature for chromatin function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

DNA damage foci at dysfunctional telomeres

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Neuronal body size correlates with the number of nucleoli and Cajal bodies, and with the organization of the splicing machinery in rat trigeminal ganglion neurons

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Rat brain oligodendrocytes do not interact selectively with axons expressing different calcium-binding proteins.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Differential regulation of bcl-2, bax, c-fos, junB, and krox-24 expression in the cerebellum of Purkinje cell degeneration mutant mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Retinal degeneration in the pcd cerebellar mutant mouse. II. Electron microscopic analysis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Degeneration of thalamic neurons in "Purkinje cell degeneration" mutant mice. I. Distribution of neuron loss.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Freeze-fracture organization of chromatin and cytoplasm in neurons and astroglia of rat cerebellar cortex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Purkinje cell degeneration, a new neurological mutation in the mouse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

The development and degeneration of Purkinje cells inpcd mutant mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Chromosome territories, nuclear architecture and gene regulation in mammalian cells

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

Nuclear topology of murine, cerebellar Purkinje neurons: changes as a function of development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

Mitral cell degeneration and sensory function in the neurological mutant mouse Purkinje cell degeneration (PCD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

Pre-neurodegeneration of mitral cells in the pcd mutant mouse is associated with DNA damage, transcriptional repression, and reorganization of nuclear speckles and Cajal bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

Emergence of endoplasmic reticulum stress and activated microglia in Purkinje cell degeneration mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

Nucleolar disruption and cajal body disassembly are nuclear hallmarks of DNA damage-induced neurodegeneration in purkinje cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

DNA repair in differentiated cells: some new answers to old questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

Apoptosis induced by methylazoxymethanol in developing rat cerebellum: organization of the cell nucleus and its relationship to DNA and rRNA degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

Acute energy reduction induces caspase-dependent apoptosis and activates p53 in retinal ganglion cells (RGC-5).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

The ATM-mediated DNA-damage response: taking shape.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

Mobility and immobility of chromatin in transcription and genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.246041

DNA fragmentation and activation of c-Jun in the cerebellum of mutant mice (weaver, Purkinje cell degeneration).

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3151073

Nuclear organization and dynamics of transcription sites in rat sensory ganglia neurons detected by incorporation of 5'-fluorouridine into nascent RNA

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21700704

12 December 2020

inferred from PubMed ID database lookup

Distribution of nuclear pores and chromatin organization in neurons and glial cells of the rat cerebellar cortex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21700704

12 December 2020

inferred from PubMed ID database lookup

Two Different Proteases Are Involved in the Proteolysis of Lamin during Apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21700704

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M111.246041

1 reference

6 August 2017

1 reference

6 August 2017

1 reference