(Q35153466)

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Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.

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14 March 2020

Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones (English)

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14 March 2020

amyotrophic lateral sclerosis

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14 March 2020

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14 March 2020

Laura Ferraiuolo

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14 March 2020

Johnathan Cooper-Knock

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14 March 2020

author name string

Joeri A Jansweijer

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14 March 2020

Philip S Webb

4

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14 March 2020

Channa A Hewamadduma

5

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14 March 2020

Paul R Heath

6

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14 March 2020

Adrian Higginbottom

7

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14 March 2020

Rohini Raman

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14 March 2020

Christopher J McDermott

11

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14 March 2020

Stephen B Wharton

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14 March 2020

Paul G Ince

14

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publication date

1 October 2014

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14 March 2020

Neuropathology and Applied Neurobiology

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14 March 2020

40

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14 March 2020

6

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14 March 2020

670-685

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14 March 2020

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

TDP-43: gumming up neurons through protein-protein and protein-RNA interactions

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Alternative isoform regulation in human tissue transcriptomes

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Misregulated RNA processing in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

TDP-43-mediated neuron loss in vivo requires RNA-binding activity

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Amplified RNA synthesized from limited quantities of heterogeneous cDNA.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Minor splicing pathway is not minor any more: implications for the pathogenesis of motor neuron diseases

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Heritability of alternative splicing in the human genome

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

The spliceosome: a self-organized macromolecular machine in the nucleus?

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Finishing the euchromatic sequence of the human genome

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Cellular stress and RNA splicing

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

The spliceosome: a flexible, reversible macromolecular machine

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Structural determinants of the cellular localization and shuttling of TDP-43.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

High correspondence between Affymetrix exon and standard expression arrays.

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

A comparison of massively parallel nucleotide sequencing with oligonucleotide microarrays for global transcription profiling

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

UG Repeats/TDP-43 Interactions near 5′ Splice Sites Exert Unpredictable Effects on Splicing Modulation

1 reference

https://api.crossref.org/works/10.1111%2FNAN.12148

21 January 2018

Identifiers

10.1111/NAN.12148

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24750229%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24750229%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

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