(Q35156244)

6 August 2017

1 reference

title

Zalcitabine. A review of its pharmacology and clinical potential in acquired immunodeficiency syndrome (AIDS) (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1281077

8 September 2022

1 reference

2

Brogden RN

1 reference

6 August 2017

R. Whittington

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1281077

8 September 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1281077

8 September 2022

publication date

1 October 1992

1 reference

6 August 2017

1 reference

6 August 2017

44

1 reference

6 August 2017

4

1 reference

6 August 2017

656-683

1 reference

https://scigraph.springernature.com/pub.10.2165/00003495-199244040-00009

6 August 2017

0 references

cites work

The role of mononuclear phagocytes in HTLV-III/LAV infection

1 reference

12 December 2020

Exacerbation of dideoxycytidine-induced neuropathy with dideoxyinosine

1 reference

12 December 2020

Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrier

1 reference

12 December 2020

2',3'-Dideoxynucleoside phosphorylation by deoxycytidine kinase from normal human thymus extracts: activation of potential drugs for AIDS therapy

1 reference

12 December 2020

Carbovir: the (—) enantiomer is a potent and selective antiviral agent against human immunodeficiency virus in vitro

1 reference

12 December 2020

The effect in vitro of 2'-deoxycytidine on the metabolism and cytotoxicity of 2',3'-dideoxycytidine

1 reference

12 December 2020

Safety and tolerance of dideoxycytidine as a single agent. Results of early-phase studies in patients with acquired immunodeficiency syndrome (AIDS) or advanced AIDS-related complex. Study Group of the AIDS Clinical Trials Group of the National Inst

1 reference

12 December 2020

The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species

1 reference

12 December 2020

Inhibition of HIV reverse transcriptase by 2',3'-dideoxynucleoside triphosphates

1 reference

12 December 2020

Pharmacokinetics of 2',3'-dideoxycytidine in patients with AIDS and related disorders.

1 reference

12 December 2020

Variability in serial CD4 counts and relation to progression of HIV-I infection to AIDS in haemophilic patients. Transfusion Safety Study Group

1 reference

12 December 2020

Azidothymidine in the treatment of AIDS

1 reference

12 December 2020

Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis

1 reference

12 December 2020

Quantitative changes in T helper or T suppressor/cytotoxic lymphocyte subsets that distinguish acquired immune deficiency syndrome from other immune subset disorders

1 reference

12 December 2020

Combination therapy with zidovudine and dideoxycytidine in patients with advanced human immunodeficiency virus infection. A phase I/II study

1 reference

12 December 2020

In vitro inhibition of the infectivity and replication of human immunodeficiency virus type 1 by combination of antiretroviral 2',3'-dideoxynucleosides and virus-binding inhibitors

1 reference

12 December 2020

Surrogate markers of disease studied as means of determining AIDS drugs' effectiveness

1 reference

12 December 2020

Direct cerebrospinal fluid delivery of an antiretroviral agent using multivesicular liposomes

1 reference

12 December 2020

3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents

1 reference

12 December 2020

Treatment considerations for children with human immunodeficiency virus infection

1 reference

12 December 2020

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

1 reference

12 December 2020

Zidovudine resistance of human immunodeficiency virus

1 reference

12 December 2020

Quantification of dideoxycytidine in human plasma by gas chromatography/mass spectrometry

1 reference

12 December 2020

The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides

1 reference

12 December 2020

Reversed-phase liquid chromatographic determination of 2',3'-dideoxycytidine in human blood samples

1 reference

12 December 2020

Surrogate markers for survival in patients with AIDS and AIDS related complex treated with zidovudine

1 reference

12 December 2020

When should asymptomatic patients with HIV infection be treated with zidovudine?

1 reference

12 December 2020

Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro

1 reference

12 December 2020

Esophageal Ulceration Related to Zalcitabine (ddC)

1 reference

12 December 2020

Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus

1 reference

12 December 2020

Endogenous interferon and triglyceride concentrations to assess response to zidovudine in AIDS and advanced AIDS-related complex

1 reference

12 December 2020

Treatment of AIDS with combinations of antiretroviral agents

1 reference

12 December 2020

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides

1 reference

12 December 2020

The effect of zidovudine treatment on serum neopterin and beta 2-microglobulin levels in mildly symptomatic, HIV type 1 seropositive individuals

1 reference

12 December 2020

Survival of zidovudine-treated patients with AIDS compared with that of contemporary untreated patients. Italian Zidovudine Evaluation Group

1 reference

12 December 2020

Dideoxycytidine metabolism in wild type and mutant CEM cells deficient in nucleoside transport or deoxycytidine kinase.

1 reference

12 December 2020

Decreases in unintegrated HIV DNA are associated with antiretroviral therapy in AIDS patients

1 reference

12 December 2020

Cytostatic effects of 2',3'-dideoxyribonucleosides on transformed human hemopoietic cell lines.

1 reference

12 December 2020

Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

1 reference

12 December 2020

Susceptibility of human immunodeficiency virus to antiviral agents measured by infectious virus yield reduction

1 reference

12 December 2020

Pyrimidine dideoxyribonucleosides: selectivity of penetration into cerebrospinal fluid

1 reference

12 December 2020

Cross-resistance to anti-HIV nucleoside analogs in multidrug-resistant human cells

1 reference

12 December 2020

The effects on survival of early treatment of human immunodeficiency virus infection

1 reference

12 December 2020

Dermatologic complications associated with administration of 2',3'-dideoxycytidine in patients with human immunodeficiency virus infection

1 reference

12 December 2020

Patterns of T lymphocyte changes with human immunodeficiency virus infection: from seroconversion to the development of AIDS.

1 reference

12 December 2020

Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides

1 reference

12 December 2020

Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction

1 reference

12 December 2020

Sources of variability in repeated T-helper lymphocyte counts from human immunodeficiency virus type 1-infected patients: total lymphocyte count fluctuations and diurnal cycle are important.

1 reference

12 December 2020

Human immunodeficiency virus inhibition is prolonged by 3'-azido-3'-deoxythymidine alternating with 2',3'-dideoxycytidine compared with 3'-azido-3'-deoxythymidine alone

1 reference

12 December 2020

Inhibition of bone marrow myelopoiesis and erythropoiesis in vitro by anti-retroviral nucleoside derivatives

1 reference

12 December 2020

Ability of anti-HIV agents to inhibit HIV replication in monocyte/macrophages or U937 monocytoid cells under conditions of enhancement by GM-CSF or anti-HIV antibody

1 reference

12 December 2020

The multidrug transporter, a double-edged sword

1 reference

12 December 2020

HIV testing. State of the art.

1 reference

12 December 2020

Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow up of the San Francisco General Hospital cohort

1 reference

12 December 2020

Alternating and intermittent regimens of zidovudine (3'-azido-3'-deoxythymidine) and dideoxycytidine (2',3'-dideoxycytidine) in the treatment of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1 reference

12 December 2020

Inhibition of HIV-1 in monocyte/macrophage cultures by 2',3'-dideoxycytidine-5'-triphosphate, free and in liposomes

1 reference

12 December 2020

The disposition and metabolism of 2',3'-dideoxycytidine, an in vitro inhibitor of human T-lymphotrophic virus type III infectivity, in mice and monkeys

1 reference

12 December 2020

Dideoxycytidine alone and in an alternating schedule with zidovudine in children with symptomatic human immunodeficiency virus infection

1 reference

12 December 2020

Survival trends for patients with AIDS.

1 reference

12 December 2020

Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2',3'-dideoxycytidine

1 reference

12 December 2020

Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).

1 reference

12 December 2020

The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.

1 reference

12 December 2020

Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages

1 reference

12 December 2020

HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy

1 reference

12 December 2020

Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay

1 reference

12 December 2020

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

1 reference

12 December 2020

HIV surrogate markers weighed

1 reference

12 December 2020

The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2‘,3‘-dideoxycytidine

1 reference

12 December 2020

Antiviral therapy in AIDS. Clinical pharmacological properties and therapeutic experience to date

1 reference

12 December 2020

Synergistic inhibition of replication of human immunodeficiency virus type 1, including that of a zidovudine-resistant isolate, by zidovudine and 2',3'-dideoxycytidine in vitro

1 reference

12 December 2020

Pharmacodynamics of 2′,3′-dideoxycytidine: An inhibitor of human immunodeficiency virus

1 reference

12 December 2020

Ototoxicity associated with dideoxycytidine

1 reference

12 December 2020

Decrease in HIV provirus in peripheral blood mononuclear cells during zidovudine and human rIL-2 administration

1 reference

12 December 2020

Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

1 reference

12 December 2020

Cardiomyopathy Associated with Antiretroviral Therapy in Patients with HIV Infection: A Report of Six Cases

1 reference

12 December 2020

Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages

1 reference

12 December 2020

Serial CD4 lymphocyte counts and development of AIDS

1 reference

12 December 2020

Comparative activities of several nucleoside analogs against duck hepatitis B virus in vitro

1 reference

12 December 2020

Projections of AIDS morbidity and mortality in San Francisco

1 reference

12 December 2020

The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

1 reference

12 December 2020

Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine

1 reference

12 December 2020

Epidemiology of women with AIDS in the United States, 1981 through 1990. A comparison with heterosexual men with AIDS.

1 reference

12 December 2020

Cellular metabolism of 2',3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro

1 reference

12 December 2020

Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.

1 reference

12 December 2020

A pilot study of the bioavailability and pharmacokinetics of 2',3'-dideoxycytidine in patients with AIDS or AIDS-related complex

1 reference

12 December 2020

Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages

1 reference

12 December 2020

Anti-HIV-1 activity of antiviral compounds, as quantitated by a focal immunoassay in CD4+ HeLa cells and a plaque assay in MT-4 cells

1 reference

12 December 2020

Infection with the human immunodeficiency virus: epidemiology, pathogenesis, transmission, diagnosis, and manifestations

1 reference

12 December 2020

Current and future dimensions of the HIV/AIDS pandemic in women and children.

1 reference

12 December 2020

2',3'-didehydro-2',3'-dideoxy-5-chlorocytidine is a selective anti-retrovirus agent

1 reference

12 December 2020

Treatment of FeLV-induced immunodeficiency syndrome (FeLV-FAIDS) with controlled release capsular implantation of 2',3'-dideoxycytidine

1 reference

12 December 2020

Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.

1 reference

12 December 2020

Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1)

1 reference

12 December 2020

Inhibitory effect of azidothymidine, 2'-3'-dideoxyadenosine, and 2'-3'-dideoxycytidine on in vitro growth of hematopoietic progenitor cells from normal persons and from patients with AIDS.

1 reference

12 December 2020

A controlled trial of early versus late treatment with zidovudine in symptomatic human immunodeficiency virus infection. Results of the Veterans Affairs Cooperative Study

1 reference

12 December 2020

Basic approaches to anti-retroviral treatment

1 reference

12 December 2020

Salvage therapy for zidovudine-intolerant HIV-infected patients with alternating and intermittent regimens of zidovudine and dideoxycytidine

1 reference

12 December 2020

Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides

1 reference

12 December 2020

Anti-human immunodeficiency virus effects of dextran sulfate are strain dependent and synergistic or antagonistic when dextran sulfate is given in combination with dideoxynucleosides

1 reference

12 December 2020

In vitro toxicity and metabolism of 2',3'-dideoxycytidine, an inhibitor of human immunodeficiency virus infectivity

1 reference

12 December 2020

Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus

1 reference

12 December 2020

Synergistic interaction of 2',3'-dideoxycytidine and recombinant interferon-alpha-A on replication of human immunodeficiency virus type 1.

1 reference

12 December 2020

Synthesis and biological evaluation of dinucleoside methylphosphonates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxycytidine

1 reference

12 December 2020

CD4 Count and the Risk for Death in Patients Infected with HIV Receiving Antiretroviral Therapy

1 reference

12 December 2020

Update on antiretroviral agents other than zidovudine

1 reference

12 December 2020

Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2',3'-dideoxycytidine (ddC).

1 reference

12 December 2020

Biological comparison of wild-type and zidovudine-resistant isolates of human immunodeficiency virus type 1 from the same subjects: susceptibility and resistance to other drugs

1 reference

12 December 2020

Circulating p24 antigen levels and responses to dideoxycytidine in human immunodeficiency virus (HIV) infections. A phase I and II study

1 reference

12 December 2020

Nucleoside and nucleobase transport in animal cells

1 reference

12 December 2020

Effects of antiretroviral dideoxynucleosides on polymorphonuclear leukocyte function

1 reference

12 December 2020

10.2165/00003495-199244040-00009

Identifiers

DOI

1 reference

Dimensions Publication ID

6 August 2017

0 references

1 reference