(Q35158014)

6 August 2017

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title

The bicyclam AMD3100 story (English)

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6 August 2017

Erik De Clercq

1

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publication date

1 July 2003

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Nature Reviews Drug Discovery

6 August 2017

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6 August 2017

2

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6 August 2017

581-587

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6 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrd1134

6 August 2017

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cites work

Antimoniotungstate (HPA 23) treatment of three patients with AIDS and one with prodrome

1 reference

Antiviral metal complexes.

31 March 2020

1 reference

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event

31 March 2020

1 reference

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

31 March 2020

1 reference

The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding

31 March 2020

1 reference

Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1.

31 March 2020

1 reference

Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

31 March 2020

1 reference

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.

31 March 2020

1 reference

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

31 March 2020

1 reference

Hamao Umezawa Memorial Award Lecture: "An Odyssey in the Viral Chemotherapy Field".

31 March 2020

1 reference

Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor

31 March 2020

1 reference

The simian immunodeficiency virus mnd(GB-1) strain uses CXCR4, not CCR5, as coreceptor for entry in human cells

31 March 2020

1 reference

A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection

31 March 2020

1 reference

The therapeutic potential of CXCR4 antagonists in the treatment of HIV.

31 March 2020

1 reference

A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor

31 March 2020

1 reference

A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity

31 March 2020

1 reference

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

31 March 2020

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Safe use of the CXCR4 inhibitor ALX40-4C in humans

31 March 2020

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G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4.

31 March 2020

1 reference

Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor

31 March 2020

1 reference

Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor

31 March 2020

1 reference

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

31 March 2020

1 reference

Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

31 March 2020

1 reference

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

31 March 2020

1 reference

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

31 March 2020

1 reference

AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.

31 March 2020

1 reference

AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity

31 March 2020

1 reference

Involvement of chemokine receptors in breast cancer metastasis

31 March 2020

1 reference

The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication

31 March 2020

1 reference

7 January 2021

Sensitivity of human immunodeficiency virus to bicyclam derivatives is influenced by the three-dimensional structure of gp120.

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7 January 2021

T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1alpha contains mutations in the envelope gp120 but does not show a switch in coreceptor use

1 reference

7 January 2021

Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry

1 reference

7 January 2021

Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NRD1134

1 reference

PubMed ID

12815382

Dimensions Publication ID

6 August 2017

0 references

1 reference

PubMed ID

12815382