(Q35159468)

6 August 2017

title

c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formation (English)

1 reference

6 August 2017

1 reference

Justine Elliott

1

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6 August 2017

Nadezhda N Zheleznova

series ordinal

2

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6 August 2017

Patricia D Wilson

series ordinal

3

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6 August 2017

language of work or name

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20 April 2011

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American Journal of Physiology - Cell Physiology

6 August 2017

published in

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6 August 2017

volume

301

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6 August 2017

issue

2

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6 August 2017

page(s)

C522-9

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Abnormalities in focal adhesion complex formation, regulation, and function in human autosomal recessive polycystic kidney disease epithelial cells

6 August 2017

cites work

1 reference

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Src inhibition ameliorates polycystic kidney disease

28 July 2018

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Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.

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Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells.

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The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation.

28 July 2018

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Disruption of polycystin-1 function interferes with branching morphogenesis of the ureteric bud in developing mouse kidneys.

28 July 2018

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Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells

28 July 2018

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The interplay between Src and integrins in normal and tumor biology

28 July 2018

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beta-catenin-mediated signaling: a molecular target for early chemopreventive intervention

28 July 2018

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Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry.

28 July 2018

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A renaissance for SRC

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28 July 2018

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Newest findings on the oldest oncogene; how activated src does it

28 July 2018

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SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading

28 July 2018

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The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells

28 July 2018

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The mechanism of cell cycle regulation by v-Src.

28 July 2018

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Role of Src expression and activation in human cancer

28 July 2018

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Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation

28 July 2018

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cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells.

28 July 2018

1 reference

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Signaling through focal adhesion kinase

28 July 2018

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Cellular functions regulated by Src family kinases

28 July 2018

1 reference

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Focal adhesion kinase in integrin signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis

28 July 2018

1 reference

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

Renal proximal tubular epithelium from patients with nephropathic cystinosis: immortalized cell lines as in vitro model systems

28 July 2018

1 reference

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Abnormal extracellular matrix and excessive growth of human adult polycystic kidney disease epithelia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.

28 July 2018

1 reference

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Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion

27 September 2018

1 reference

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Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

c-Src and cooperating partners in human cancer

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

Multiple connections link FAK to cell motility and invasion

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

Decreased Src tyrosine kinase activity inhibits malignant human ovarian cancer tumor growth in a nude mouse model.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

Integrin signalling and tyrosine phosphorylation: just the FAKs?

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154563

Src Induces Urokinase Receptor Gene Expression and Invasion/Intravasation via Activator Protein-1/p-c-Jun in Colorectal Cancer

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1152%2FAJPCELL.00163.2010

A new method for studying human polycystic kidney disease epithelia in culture

21 January 2018

1 reference

12 December 2020

Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD

1 reference

12 December 2020

Role of lactosylceramide and MAP kinase in the proliferation of proximal tubular cells in human polycystic kidney disease

1 reference

12 December 2020

Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma

1 reference

12 December 2020

Identification of phosphorylation sites in the PKD1-encoded protein C-terminal domain

1 reference

12 December 2020

The PKD1 gene product, "polycystin-1," is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia

1 reference

12 December 2020

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

1 reference

12 December 2020

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects

1 reference

12 December 2020

Polycystic kidney disease

1 reference

12 December 2020

10.1152/AJPCELL.00163.2010

Identifiers

DOI

1 reference

release_jvmf22rkp5gzrlmglkbdokqmtu

6 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jvmf22rkp5gzrlmglkbdokqmtu

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3154563

1 reference

6 August 2017

1 reference