(Q37604891)

21 August 2017

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title

Src kinases as therapeutic targets for cancer (English)

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21 August 2017

Lori C Kim

1

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21 August 2017

Lanxi Song

series ordinal

2

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21 August 2017

Eric B Haura

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

1 October 2009

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Nature Reviews Clinical Oncology

21 August 2017

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21 August 2017

6

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21 August 2017

587-595

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21 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrclinonc.2009.129

21 August 2017

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cites work

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Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry.

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RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

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Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene

21 January 2018

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A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

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31 March 2020

The hunting of the Src

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

31 March 2020

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A novel viral oncogene with structural similarity to phospholipase C

31 March 2020

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Three-dimensional structure of the tyrosine kinase c-Src

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Crystal structure of the Src family tyrosine kinase Hck

31 March 2020

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31 March 2020

A renaissance for SRC

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Role of Src expression and activation in human cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Targeting Src in breast cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Src as a potential therapeutic target in non-small-cell lung cancer.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Solution structure of the SH3 domain of Src and identification of its ligand-binding site

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Phosphotyrosine-binding domains in signal transduction

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Activating SRC mutation in a subset of advanced human colon cancers

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Role of the cytoplasmic tyrosines of beta 1A integrins in transformation by v-src

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Phosphorylation of beta3 integrin controls ligand binding strength

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Adherens and tight junctions: structure, function and connections to the actin cytoskeleton

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Emerging roles for p120-catenin in cell adhesion and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Differential regulation of cell motility and invasion by FAK

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

The signaling and biological implications of FAK overexpression in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Role of c-Src tyrosine kinase in EGF-induced mitogenesis.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Association between the PDGF receptor and members of the src family of tyrosine kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Angiogenesis as a therapeutic target

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Interleukin-8 and human cancer biology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Src continues aging: current and future clinical directions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Identification of Src transformation fingerprint in human colon cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Inhibitory role of Src family tyrosine kinases on Ca2+-dependent insulin release

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Src as a therapeutic target in anti-hormone/anti-growth factor-resistant breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

A quantitative analysis of kinase inhibitor selectivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

pp60c-src activation in lung adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

A Src/Abl kinase inhibitor, SKI-606, blocks breast cancer invasion, growth, and metastasis in vitro and in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Expression of pp60c-src in human small cell and non-small cell lung carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

The role of Src in solid and hematologic malignancies: development of new-generation Src inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Regulation of cytochrome c oxidase activity by c-Src in osteoclasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Decreased c-Src expression enhances osteoblast differentiation and bone formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Platelet and osteoclast β 3 integrins are critical for bone metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2009.129

Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells

31 March 2020

1 reference

12 December 2020

1 reference

12 December 2020

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis

1 reference

12 December 2020

Non-receptor protein-tyrosine kinases as molecular targets for antiangiogenic therapy (Review).

1 reference

12 December 2020

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases

1 reference

12 December 2020

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice

1 reference

12 December 2020

Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.

1 reference

12 December 2020

Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells.

1 reference

12 December 2020

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression

1 reference

12 December 2020

10.1038/NRCLINONC.2009.129

Identifiers

DOI

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Dimensions Publication ID

21 August 2017

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