(Q36598516)

15 August 2017

1 reference

title

The role of Src in solid and hematologic malignancies: development of new-generation Src inhibitors (English)

1 reference

15 August 2017

2

Hagop M Kantarjian

1 reference

15 August 2017

3

Jorge E Cortes

1 reference

15 August 2017

Ricardo H Alvarez

1

1 reference

PubMed ID

16986126

15 August 2017

language of work or name

English

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publication date

1 October 2006

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15 August 2017

12

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inferred from page(s)

published in

Cancer

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15 August 2017

107

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15 August 2017

1918-1929

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15 August 2017

8

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Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events

15 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

Aberrant Elevation of Tyrosine-specific Phosphorylation in Human Gastric Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Rous sarcoma virus: a function required for the maintenance of the transformed state

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Cellular functions regulated by Src family kinases

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Selected glimpses into the activation and function of Src kinase

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

c-Src tyrosine phosphorylation of epidermal growth factor receptor, P190 RhoGAP, and focal adhesion kinase regulates diverse cellular processes

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Src homology-2 domains: structure, mechanisms, and drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Active and inactive protein kinases: structural basis for regulation

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Tyr527 is phosphorylated in pp60c-src: implications for regulation

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Src kinase regulation by phosphorylation and dephosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Overexpression of the csk gene suppresses tumor metastasis in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Carboxyl-terminal Src kinase homologous kinase negatively regulates the chemokine receptor CXCR4 through YY1 and impairs CXCR4/CXCL12 (SDF-1alpha)-mediated breast cancer cell migration

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Src family kinases in tumor progression and metastasis

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Signal characteristics of G protein-transactivated EGF receptor

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Rho GTPases and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Biochemical signals and biological responses elicited by the focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Role of Src expression and activation in human cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Activation of pp60c-src protein kinase activity in human colon carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Site-specific differences in pp60c-src activity in human colorectal metastases

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Activating SRC mutation in a subset of advanced human colon cancers

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Translational activation of the lck proto-oncogene

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Expression of pp60c-src in human small cell and non-small cell lung carcinomas

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Src activation in malignant and premalignant epithelia of Barrett's esophagus

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Urokinase type plasminogen activator receptor expression in colorectal neoplasms

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Combination of an SRC kinase inhibitor with a novel pharmacological antagonist of the urokinase receptor diminishes in vitro colon cancer invasiveness

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

The role of fibroblast growth factors in vascular development

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Reduction of c-Src activity by substituted 5,7-diphenyl-pyrrolo[2,3-d]-pyrimidines induces osteoclast apoptosis in vivo and in vitro. Involvement of ERK1/2 pathway.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Structural basis for the autoinhibition of c-Abl tyrosine kinase

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Overriding imatinib resistance with a novel ABL kinase inhibitor

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.22215

7 January 2021

Identifiers

DOI

10.1002/CNCR.22215

1 reference

15 August 2017

1 reference

PubMed ID

16986126