(Q35161137)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21548007%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program (English)

1 reference

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30 January 2020

2

1 reference

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30 January 2020

Richard G Gorlick

5

1 reference

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30 January 2020

C P Reynolds

8

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30 January 2020

Min H Kang

9

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30 January 2020

Malcolm A Smith

15

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30 January 2020

1

Peter J Houghton

1 reference

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30 January 2020

10

John M Maris

1 reference

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30 January 2020

6

E Anders Kolb

1 reference

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30 January 2020

7

Stephen T Keir

1 reference

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30 January 2020

3

Hernan Carol

1 reference

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30 January 2020

14

Beverly A Teicher

1 reference

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30 January 2020

11

Catherine A Billups

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30 January 2020

author name string

Christopher L Morton

4

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30 January 2020

Mindy X Zhang

12

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30 January 2020

Stephen L Madden

13

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30 January 2020

publication date

5 May 2011

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30 January 2020

published in

Pediatric Blood Cancer

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30 January 2020

volume

58

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30 January 2020

issue

2

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30 January 2020

page(s)

200-209

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Cellular strategies for regulating DNA supercoiling: a single-molecule perspective

30 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Initial testing of topotecan by the pediatric preclinical testing program.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Bone marrow and tumor cell colony-forming units and human tumor xenograft efficacy of noncamptothecin and camptothecin topoisomerase I inhibitors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Molecular characterization of the pediatric preclinical testing panel

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Phase II trial of irinotecan in children with relapsed or refractory rhabdomyosarcoma: a joint study of the French Society of Pediatric Oncology and the United Kingdom Children's Cancer Study Group

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Predicting the clinical status of human breast cancer by using gene expression profiles

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

DNA topoisomerase I inhibitors.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Clinical status and optimal use of topotecan

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Phase I trial and pharmacokinetic (PK) and pharmacodynamics (PD) study of topotecan using a five-day course in children with refractory solid tumors: a pediatric oncology group study

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Potent therapeutic activity of irinotecan (CPT-11) and its schedule dependency in medulloblastoma xenografts in nude mice.

28 July 2018

1 reference

Improved response in high-risk neuroblastoma with protracted topotecan administration using a pharmacokinetically guided dosing approach

21 January 2018

1 reference

Cefixime allows greater dose escalation of oral irinotecan: a phase I study in pediatric patients with refractory solid tumors

21 January 2018

1 reference

The pediatric preclinical testing program: description of models and early testing results.

21 January 2018

1 reference

A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay

21 January 2018

1 reference

Efficacy of systemic administration of irinotecan against neuroblastoma xenografts.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154998

Antitumour drugs impede DNA uncoiling by topoisomerase I

27 September 2018

1 reference

Guidelines for accurate EC50/IC50 estimation

21 January 2018

1 reference

12 December 2020

Direct translation of a protracted irinotecan schedule from a xenograft model to a phase I trial in children

1 reference

12 December 2020

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

1 reference

12 December 2020

Topotecan in colorectal cancer: a phase II study of the EORTC early clinical trials group

1 reference

12 December 2020

Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro

1 reference

12 December 2020

Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment

1 reference

12 December 2020

Identifiers

DOI

10.1002/PBC.23016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21548007%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21548007%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference