(Q35161589)

6 August 2017

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title

Proteolytic signaling by TNFalpha: caspase activation and IkappaB degradation (English)

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6 August 2017

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Xiaotang Hu

1

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6 August 2017

language of work or name

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1 March 2003

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6 August 2017

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6 August 2017

volume

21

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6 August 2017

issue

6

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6 August 2017

page(s)

286-294

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Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor

6 August 2017

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7 January 2021

Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B

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7 January 2021

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha

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7 January 2021

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

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7 January 2021

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

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7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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7 January 2021

Function and activation of NF-kappa B in the immune system

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7 January 2021

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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7 January 2021

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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7 January 2021

A novel domain within the 55 kd TNF receptor signals cell death

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7 January 2021

Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95

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7 January 2021

Identification and characterization of a new member of the TNF family that induces apoptosis

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7 January 2021

Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

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7 January 2021

The receptor for the cytotoxic ligand TRAIL

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7 January 2021

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

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7 January 2021

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

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7 January 2021

Prevention of constitutive TNF receptor 1 signaling by silencer of death domains

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7 January 2021

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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7 January 2021

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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7 January 2021

FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

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7 January 2021

Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/stre

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7 January 2021

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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7 January 2021

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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7 January 2021

Identification and characterization of an IkappaB kinase

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7 January 2021

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease

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7 January 2021

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

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7 January 2021

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

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7 January 2021

Molecular cloning of the interleukin-1 beta converting enzyme

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7 January 2021

Caspases: killer proteases

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7 January 2021

Human ICE/CED-3 protease nomenclature

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7 January 2021

Structure and mechanism of interleukin-1 beta converting enzyme

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7 January 2021

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

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7 January 2021

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

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7 January 2021

Autoproteolytic activation of pro-caspases by oligomerization

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7 January 2021

Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal

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7 January 2021

An induced proximity model for caspase-8 activation.

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7 January 2021

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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7 January 2021

Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo

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7 January 2021

Dimerization and autoprocessing of the Nedd2 (caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions

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7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

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7 January 2021

FLICE Induced Apoptosis in a Cell-free System

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7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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7 January 2021

Lethal effect of the anti-Fas antibody in mice

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7 January 2021

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

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7 January 2021

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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7 January 2021

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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7 January 2021

Death by a thousand cuts: an ever increasing list of caspase substrates

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7 January 2021

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

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7 January 2021

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1 reference

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7 January 2021

Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

1 reference

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7 January 2021

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

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7 January 2021

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Autoregulation of I kappa B alpha activity

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines

1 reference

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7 January 2021

Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

1 reference

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7 January 2021

Catalysis by a multiprotein IkappaB kinase complex

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7 January 2021

NF-kappaB activation: the I kappaB kinase revealed?

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7 January 2021

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

1 reference

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7 January 2021

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

1 reference

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7 January 2021

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B

1 reference

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7 January 2021

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

1 reference

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7 January 2021

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha

1 reference

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7 January 2021

Pathways of ubiquitin conjugation.

1 reference

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7 January 2021

Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Activation of a pro-apoptotic amplification loop through inhibition of NF-kappaB-dependent survival signals by caspase-mediated inactivation of RIP

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

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7 January 2021

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

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https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1016%2FS1043-4666%2803%2900107-8

7 January 2021

10.1016/S1043-4666(03)00107-8

Identifiers

DOI

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6 August 2017

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