(Q35161856)

6 August 2017

title

Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis (English)

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6 August 2017

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Zhongquan Zhao

1

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6 August 2017

Xiaoming Cheng

2

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6 August 2017

Yubo Wang

3

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6 August 2017

Rui Han

4

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6 August 2017

Li Li

5

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6 August 2017

Tong Xiang

6

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6 August 2017

Luhang He

7

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6 August 2017

Haixia Long

8

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6 August 2017

Bo Zhu

9

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6 August 2017

Yong He

10

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6 August 2017

language of work or name

English

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publication date

30 April 2014

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6 August 2017

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6 August 2017

volume

9

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6 August 2017

issue

4

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6 August 2017

page(s)

e95884

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Creative Commons Attribution 4.0 International

6 August 2017

copyright license

start time

30 April 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

28 July 2018

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L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer

28 July 2018

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The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic cancer cells in vitro

28 July 2018

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Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition

28 July 2018

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Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status

28 July 2018

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AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).

28 July 2018

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The role of ZEB1 in the inflammation-induced promotion of EMT in HNSCC.

28 July 2018

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Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena

28 July 2018

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Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

28 July 2018

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28 July 2018

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miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy

28 July 2018

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Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells.

28 July 2018

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Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis

28 July 2018

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28 July 2018

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

28 July 2018

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Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

28 July 2018

1 reference

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Inflammation and cancer: IL-6 and STAT3 complete the link.

28 July 2018

1 reference

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The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

28 July 2018

1 reference

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Expression of snail in pancreatic cancer promotes metastasis and chemoresistance

28 July 2018

1 reference

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The role of epithelial-mesenchymal transition in cancer pathology

28 July 2018

1 reference

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Interplay of distinct growth factors during epithelial mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Inflammation and cancer: how hot is the link?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Metformin and reduced risk of cancer in diabetic patients

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Epithelial-mesenchymal transitions in tumour progression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Involvement of STAT3 in immune evasion during lung tumorigenesis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

The role of STAT3 activation in modulating the immune microenvironment of GBM.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Overexpression of NEDD9 is associated with altered expression of E-Cadherin, β-Catenin and N-Cadherin and predictive of poor prognosis in non-small cell lung cancer

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Familial diabetes is associated with reduced risk of cancer in diabetic patients: a possible role for metformin

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4005743

Significance of the correlation between the expression of interleukin 6 and clinical features in patients with non-small cell lung cancer

27 September 2018

1 reference

12 December 2020

Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelial transition protein expression in non-small cell lung cancer

1 reference

12 December 2020

Serum concentrations of proinflammatory cytokines in advanced non small cell lung cancer patients

1 reference

12 December 2020

Serum levels of cytokines in patients with untreated primary lung cancer

1 reference

12 December 2020

The expression of CD146 predicts a poor overall survival in patients with adenocarcinoma of the lung

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0095884

Identifiers

DOI

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6 August 2017

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6 August 2017

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