(Q39676938)

English

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).

scientific article published on 24 July 2010

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3). (English)

1 reference

Europe PubMed Central

13 September 2017

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phosphorylation

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based on heuristic

inferred from title

Margit Mahlapuu

object named as

M Mahlapuu

6

0 references

2

object named as

A Johansson

1 reference

Europe PubMed Central

13 September 2017

author name string

A Nerstedt

1

1 reference

Europe PubMed Central

13 September 2017

C X Andersson

3

1 reference

Europe PubMed Central

13 September 2017

E Cansby

4

1 reference

Europe PubMed Central

13 September 2017

U Smith

5

1 reference

Europe PubMed Central

13 September 2017

publication date

24 July 2010

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Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

53

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Europe PubMed Central

13 September 2017

11

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Europe PubMed Central

13 September 2017

2406-2416

1 reference

Europe PubMed Central

13 September 2017

https://scigraph.springernature.com/pub.10.1007/s00125-010-1856-z

0 references

Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Five-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates poly (I:C)-induced airway inflammation in a murine model of asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase: balancing the scales.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase signaling in metabolic regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 induces cellular insulin resistance in hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of suppressors of cytokine signaling during liver regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, stress, and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARgamma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and metabolic disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormonal regulation of liver fatty acid-binding protein in vivo and in vitro: effects of growth hormone and insulin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 6, the third mediator of acute-phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 beta and tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of AMP-activated protein kinase by upstream kinases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a potent antiinflammatory effect of rosiglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin reduces C-reactive protein but not complement factor C3 in overweight patients with Type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of hepatic STAT3 in the regulation of lipid metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle-derived interleukin-6: mechanisms for activation and possible biological roles

1 reference

https://pubmed.ncbi.nlm.nih.gov/20652679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-010-1856-Z

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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