(Q35164428)

English

Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3.

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29 February 2020

Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3 (English)

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29 February 2020

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Thomas E. Carey

7

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29 February 2020

J. Silvio Gutkind

14

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29 February 2020

author name string

Dmitri Madera

1

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29 February 2020

Lynn Vitale-Cross

2

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29 February 2020

Daniel Martin

3

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29 February 2020

Abraham Schneider

4

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29 February 2020

Alfredo A Molinolo

5

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29 February 2020

Nitin Gangane

6

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29 February 2020

Jonathan B McHugh

8

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29 February 2020

Christine M Komarck

9

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29 February 2020

Heather M Walline

10

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29 February 2020

William N William

11

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29 February 2020

Raja R Seethala

12

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29 February 2020

Robert L Ferris

13

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29 February 2020

publication date

13 February 2015

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29 February 2020

Cancer Prevention Research

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29 February 2020

8

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29 February 2020

197-207

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29 February 2020

3

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Europe PubMed Central

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29 February 2020

Metformin in cancer prevention and therapy

1 reference

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Exploring the role of metformin in anticancer treatments: a systematic review.

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13 July 2018

Strategies for the management of adverse events associated with mTOR inhibitors

1 reference

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13 July 2018

Use of antidiabetic drugs in the U.S., 2003-2012.

1 reference

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13 July 2018

Recurrent and second primary squamous cell carcinoma of the head and neck: when and how to reirradiate

1 reference

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13 July 2018

Integration of molecular targeted therapy with radiation in head and neck cancer

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13 July 2018

Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling

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13 July 2018

Distribution of human papillomavirus genotypes, assessment of HPV 16 and 18 viral load and anal related lesions in HIV positive patients: a cross-sectional analysis

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13 July 2018

Potential applications for biguanides in oncology

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13 July 2018

Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition.

1 reference

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13 July 2018

Head and neck cancer stem cells: the effect of HPV--an in vitro and mouse study

1 reference

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13 July 2018

Cancer statistics, 2013

1 reference

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13 July 2018

Annual Report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on glucose concentration and role of AMPK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

In vitro and in vivo anti-tumor effect of metformin as a novel therapeutic agent in human oral squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

Differential expression of organic cation transporter OCT-3 in oral premalignant and malignant lesions: potential implications in the antineoplastic effects of metformin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

The effectiveness of metformin ovulation induction treatment in patients with PCOS: a systematic review and meta-analysis

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13 July 2018

Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

mTOR inhibitors and its role in the treatment of head and neck squamous cell carcinoma

1 reference

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13 July 2018

Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

Clinical Pharmacokinetics of Metformin

1 reference

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13 July 2018

Mechanisms underlying resistance to cetuximab in the HNSCC cell line: role of AKT inhibition in bypassing this resistance.

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13 July 2018

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

The efficacy and safety of insulin-sensitizing drugs in HIV-associated lipodystrophy syndrome: a meta-analysis of randomized trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin

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13 July 2018

Risk of human papillomavirus-associated cancers among persons with AIDS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355306

13 July 2018

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

1 reference

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13 July 2018

Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions.

1 reference

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13 July 2018

Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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13 July 2018

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

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13 July 2018

The causal relation between human papillomavirus and cervical cancer

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13 July 2018

Role of AMP-activated protein kinase in mechanism of metformin action

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13 July 2018

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Effect of metformin on the incidence of head and neck cancer in diabetics.

1 reference

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Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.

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27 September 2018

The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c.

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Organic cation transporter 1 polymorphisms predict the metabolic response to metformin in women with the polycystic ovary syndrome

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27 September 2018

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Metformin in the treatment of HIV lipodystrophy syndrome: A randomized controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/25681087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003

1 reference

https://pubmed.ncbi.nlm.nih.gov/25681087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1940-6207.CAPR-14-0348

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Europe PubMed Central

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29 February 2020

1 reference

Europe PubMed Central

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29 February 2020

1 reference

Europe PubMed Central

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29 February 2020

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