(Q37009828)

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Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions.

scientific article published on 02 October 2008

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scholarly article

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18 January 2020

Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions (English)

1 reference

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18 January 2020

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Wei Feng

1

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18 January 2020

Xiuzhen Duan

2

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18 January 2020

Jinsong Liu

3

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18 January 2020

Jianguo Xiao

4

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18 January 2020

Robert E Brown

5

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18 January 2020

publication date

2 October 2008

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18 January 2020

International Journal of Clinical and Experimental Pathology

1 reference

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18 January 2020

2

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18 January 2020

3

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18 January 2020

249-260

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18 January 2020

Expression of signaling mediators downstream of EGF-receptor predict sensitivity to small molecule inhibitors directed against the EGF-receptor pathway

1 reference

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1 reference

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1 reference

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1 reference

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29 September 2017

Opportunities to improve the prevention and treatment of cervical cancer

1 reference

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1 reference

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Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy.

1 reference

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29 September 2017

Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors

1 reference

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29 September 2017

Increased expression of SKP2 and phospho-MAPK/ERK1/2 and decreased expression of p27 during tumor progression of cervical neoplasms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

Morphoproteomic and molecular concomitants of an overexpressed and activated mTOR pathway in renal cell carcinomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

Morphoproteomic and pharmacoproteomic rationale for mTOR effectors as therapeutic targets in head and neck squamous cell carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells

1 reference

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29 September 2017

The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

1 reference

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29 September 2017

Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein

1 reference

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29 September 2017

Clinical advancement of EGFR inhibitors in cancer therapy

1 reference

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29 September 2017

Ras, PI(3)K and mTOR signalling controls tumour cell growth

1 reference

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29 September 2017

Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling

1 reference

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29 September 2017

A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1.

1 reference

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29 September 2017

Mammalian target of rapamycin as a therapeutic target in leukemia

1 reference

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29 September 2017

Morphoproteomics: exposing protein circuitries in tumors to identify potential therapeutic targets in cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors

1 reference

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Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs.

1 reference

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29 September 2017

RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells

1 reference

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29 September 2017

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2600462

29 September 2017

The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes

1 reference

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29 September 2017

Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions

1 reference

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29 September 2017

Regulation of PDGF production and ERK activation by estrogen is associated withTSC2gene expression

1 reference

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27 June 2018

Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.

1 reference

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4 September 2018

Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation

1 reference

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4 September 2018

Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts

1 reference

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4 September 2018

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

1 reference

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4 September 2018

Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer

1 reference

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4 September 2018

Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity

1 reference

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4 September 2018

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1 reference

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4 September 2018

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

1 reference

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1 reference

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4 December 2018

Selective silencing of viral gene E6 and E7 expression in HPV-positive human cervical carcinoma cells using small interfering RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19079619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Expression and clinical significance of phosphatidylinositol 3-kinase and protein kinase B in cervical carcinoma]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19079619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19079619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting persistent/recurrent disease in the cervix after excisional biopsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19079619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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Europe PubMed Central

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18 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19079619%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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