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Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C.
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12834855
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12834855%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12834855
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12834855%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
main subject
chronic hepatitis
1 reference
based on heuristic
inferred from title
author
Jean-Michel Pawlotsky
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12834855
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12834855%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
author name string
Jean Michel Pawlotsky
series ordinal
1
1 reference
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Europe PubMed Central
PubMed publication ID
12834855
retrieved
6 August 2017
publication date
1 June 2003
1 reference
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Europe PubMed Central
PubMed publication ID
12834855
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12834855%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
published in
Antiviral Research
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12834855
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12834855%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
volume
59
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12834855
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12834855%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
issue
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12834855
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12834855%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
page(s)
1-11
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12834855
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12834855%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
cites work
National Institutes of Health Consensus Development Conference Statement: Management of hepatitis C: 2002--June 10-12, 2002.
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Viral kinetics in genotype 1 chronic hepatitis C patients during therapy with 2 different doses of peginterferon alfa-2b plus ribavirin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RNA virus error catastrophe: direct molecular test by using ribavirin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of increasing dose of interferon on the evolution of hepatitis C virus 1b quasispecies.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Southeast Asian patients with chronic hepatitis C: the impact of novel genotypes and race on treatment outcome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prevention and treatment of hepatitis C in injection drug users
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Surprisingly small effect of antiviral treatment in patients with hepatitis C.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ribavirin enhancement of hepatitis C virus core antigen-specific type 1 T helper cell response correlates with the increased IL-12 level
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Early changes in hepatitis C viral quasispecies during interferon therapy predict the therapeutic outcome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of retreatment with interferon alone or interferon plus ribavirin on hepatitis C virus quasispecies diversification in nonresponder patients with chronic hepatitis C.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clinical implications of viral quasispecies heterogeneity in chronic hepatitis C.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of alpha interferon on the hepatitis C virus replicon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of chronic non-A,non-B hepatitis with recombinant human alpha interferon. A preliminary report
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of acute hepatitis C with interferon alfa-2b
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Viruses and interferon: a fight for supremacy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
African Americans with genotype 1 treated with interferon for chronic hepatitis C have a lower end of treatment response than Caucasians
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dose-dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antiviral effect and virus-host interactions in response to alpha interferon, gamma interferon, poly(i)-poly(c), tumor necrosis factor alpha, and ribavirin in hepatitis C virus subgenomic replicons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of action of ribavirin in the combination treatment of chronic HCV infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The impact of interferon plus ribavirin on response to therapy in black patients with chronic hepatitis C. The International Hepatitis Interventional Therapy Group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The immunopathogenesis of hepatitis C virus infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DITTO-HCV early viral kinetics report - novel decline patterns in gen 1 but not gen 2–3 patients treated with PEG-interferon-alfa-2a and ribavirin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Variation in the hepatitis C virus NS5a region in relation to hypervariable region 1 heterogeneity during interferon treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatitis C virus genetic variability: pathogenic and clinical implications
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evolution of the hepatitis C virus second envelope protein hypervariable region in chronically infected patients receiving alpha interferon therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Factors affecting treatment responses to interferon-alpha in chronic hepatitis C.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conservation of the Conformation and Positive Charges of Hepatitis C Virus E2 Envelope Glycoprotein Hypervariable Region 1 Points to a Role in Cell Attachment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural biology of hepatitis C virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Actions of cytokines on the immune response and viral interactions: an overview
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (I
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Is an "a la carte" combination interferon alfa-2b plus ribavirin regimen possible for the first line treatment in patients with chronic hepatitis C? The ALGOVIRC Project Group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evolution of hepatitis C virus genome in chronically infected patients receiving ribavirin monotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Racial differences in responses to therapy with interferon in chronic hepatitis C. Consensus Interferon Study Group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatitis C virus nonstructural 5A protein and interferon resistance: a new model for testing the reliability of mutational analyses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Viral heterogeneity of the hepatitis C virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Quasispecies heterogeneity and constraints on the evolution of the 5' noncoding region of hepatitis C virus (HCV): relationship with HCV resistance to interferon-alpha therapy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatitis C in the HIV-Infected Person
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influence of three successive antiviral treatments on viral heterogeneity in nonresponder chronic hepatitis C patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New insights into the mechanisms of interferon alfa: an immunoregulatory and anti-inflammatory cytokine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Viral kinetics in patients with chronic hepatitis C treated with standard or peginterferon alpha2a
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900088-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0166-3542(03)00088-3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12834855
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12834855%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
PubMed publication ID
12834855
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12834855
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12834855%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
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