(Q35166601)

6 August 2017

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title

Molecular targets of lead in brain neurotoxicity (English)

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6 August 2017

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Carla Marchetti

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publication date

1 January 2003

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6 August 2017

published in

Neurotoxicity Research

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6 August 2017

volume

5

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6 August 2017

issue

3

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6 August 2017

page(s)

221-236

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https://scigraph.springernature.com/pub.10.1007/bf03033142

6 August 2017

exact match

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cites work

Relationships between lead-induced learning impairments and changes in dopaminergic, cholinergic, and glutamatergic neurotransmitter system functions

1 reference

https://api.crossref.org/works/10.1007%2FBF03033142

Selective vulnerability of the developing brain to lead

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033142

Uncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptors alter the mRNA expression of proteins associated with the NMDA receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033142

The role of anion transport in the passive movement of lead across the human red cell membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033142

Full reversal of Pb++ block of L-type Ca++ channels requires treatment with heavy metal antidotes.

21 January 2018

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12 December 2020

Evidence that lead acts as a calcium substitute in second messenger metabolism.

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12 December 2020

Blockade of mammalian and invertebrate calcium channels by lead

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12 December 2020

Molecular changes in glutamatergic synapses induced by Pb2+: association with deficits of LTP and spatial learning

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12 December 2020

Chronic prenatal and postnatal Pb2+ exposure increases [3H]MK801 binding sites in adult rat forebrain

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12 December 2020

Developmental change of the inhibition by lead of NMDA-activated currents in cultured hippocampal neurons

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12 December 2020

NMDA receptor subunits: diversity, development and disease

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12 December 2020

Presynaptic glutamatergic function in dentate gyrus in vivo is diminished by chronic exposure to inorganic lead.

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12 December 2020

The glutamate receptor ion channels

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12 December 2020

Disruption of the zinc finger domain: a common target that underlies many of the effects of lead

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12 December 2020

Synaptic activity-dependent developmental regulation of NMDA receptor subunit expression in cultured neocortical neurons.

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12 December 2020

Differential ability of astroglia and neuronal cells to accumulate lead: dependence on cell type and on degree of differentiation

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12 December 2020

Chronic developmental lead exposure increases the threshold for long-term potentiation in rat dentate gyrus in vivo.

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12 December 2020

Atypical neural messengers

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12 December 2020

Cellular uptake of lead is activated by depletion of intracellular calcium stores

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12 December 2020

The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead

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12 December 2020

The influence of Pb2+ on expression of acetylcholinesterase and the acetylcholine receptor

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12 December 2020

Development of an in vitro test battery for the estimation of acute human systemic toxicity: An outline of the EDIT project. Evaluation-guided Development of New In Vitro Test Batteries.

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12 December 2020

Multisite interactions between Pb2+ and protein kinase C and its role in norepinephrine release from bovine adrenal chromaffin cells

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12 December 2020

Ca(2+) -independent vesicular catecholamine release in PC12 cells by nanomolar concentrations of Pb(2+).

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12 December 2020

Immediate early gene expression in PC12 cells exposed to lead: requirement for protein kinase C

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12 December 2020

Protein-independent lead permeation through myelin lipid liposomes

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12 December 2020

Transport of lead-203 at the blood-brain barrier during short cerebrovascular perfusion with saline in the rat.

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12 December 2020

Toxicology of choroid plexus: special reference to metal-induced neurotoxicities

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12 December 2020

Molecular and ionic mimicry of toxic metals

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12 December 2020

Pb2+ reduces the current from NMDA receptors expressed in Xenopus oocytes.

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12 December 2020

Low-level lead-induced neurotoxicity in children: an update on central nervous system effects

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12 December 2020

Effects of lead exposure on long-term potentiation induced by 2-deoxy-D-glucose in area CA1 of rat hippocampus in vitro

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12 December 2020

Chronic exposure to environmental levels of lead impairs in vivo induction of long-term potentiation in rat hippocampal dentate

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12 December 2020

Lead activation of protein kinase C from rat brain. Determination of free calcium, lead, and zinc by 19F NMR.

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12 December 2020

Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats.

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12 December 2020

Glutamatergic system and developmental lead neurotoxicity.

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12 December 2020

Molecular mechanisms of lead neurotoxicity

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12 December 2020

Different trends in modulation of NMDAR1 and NMDAR2B gene expression in cultured cortical and hippocampal neurons after lead exposure

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12 December 2020

Ontogenically related properties of N-methyl-D-aspartate receptors in rat hippocampal neurons and the age-specific sensitivity of developing neurons to lead

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12 December 2020

Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons

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12 December 2020

Age-dependent effects of developmental lead exposure on performance in the Morris water maze.

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12 December 2020

Lead-induced abnormalities in blood-brain barrier permeability in experimental chronic toxicity.

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12 December 2020

Low-level lead exposure in the early postnatal period results in persisting neuroplastic deficits associated with memory consolidation

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12 December 2020

Lead increases tetrodotoxin-insensitive spontaneous release of glutamate and GABA from hippocampal neurons

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12 December 2020

Developmental lead exposure causes spatial learning deficits in adult rats.

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12 December 2020

Analysis of Pb2+ entry into cultured astroglia

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12 December 2020

The sensitivity of N-methyl-D-aspartate receptors to lead inhibition is dependent on the receptor subunit composition.

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12 December 2020

Silent synapses in developing cerebellar granule neurons

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12 December 2020

Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.

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12 December 2020

Lipopolysaccharide and interleukin-6 enhance lead entry into cerebellar neurons: application of a new and sensitive flow cytometric technique to measure intracellular lead and calcium concentrations.

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12 December 2020

The influence of developmental period of lead exposure on long-term potentiation in the adult rat dentate gyrus in vivo.

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12 December 2020

Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding

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12 December 2020

Lead inhibition of DNA-binding mechanism of Cys(2)His(2) zinc finger proteins

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12 December 2020

NMDAR-2A subunit protein expression is reduced in the hippocampus of rats exposed to Pb2+ during development

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12 December 2020

Pb-induced alterations in tyrosine hydroxylase activity in rat brain

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12 December 2020

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

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12 December 2020

Effects of subacute lead exposure on [3H]MK-801 binding in hippocampus and cerebral cortex in the adult rat.

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12 December 2020

NMDA receptor subunits in the postsynaptic density of rat brain: expression and phosphorylation by endogenous protein kinases.

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12 December 2020

In vitro and in vivo effects of lead on specific 3H-MK-801 binding to NMDA-receptors in the brain of mice

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12 December 2020

Effect of developmental lead exposure on the expression of specific NMDA receptor subunit mRNAs in the hippocampus of neonatal rats by digoxigenin-labeled in situ hybridization histochemistry

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12 December 2020

Effects of chronic developmental lead exposure on monkey neuroanatomy: visual system.

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12 December 2020

Lead poisoning: a disease for the next millennium

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12 December 2020

Impairment of long-term potentiation and paired-pulse facilitation in rat hippocampal dentate gyrus following developmental lead exposure in vivo.

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12 December 2020

Lead inhibits the rat N-methyl-d-aspartate receptor channel by binding to a site distinct from the zinc allosteric site

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12 December 2020

Pb2+ reduces voltage- and N-methyl-D-aspartate (NMDA)-activated calcium channel currents

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12 December 2020

Synaptic plasticity in the CA1 and CA3 hippocampal region of pre- and postnatally lead-exposed rats.

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12 December 2020

Inorganic lead and calcium interact positively in activation of calmodulin

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12 December 2020

Lead transport and binding by human erythrocytes in vitro

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12 December 2020

Biochemical evidence of an interaction of lead at the zinc allosteric sites of the NMDA receptor complex: effects of neuronal development

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12 December 2020

Effects of low level lead exposure on cognitive function in children: a review of behavioral, neuropsychological and biological evidence

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12 December 2020

Mammalian voltage-activated calcium channel currents are blocked by Pb2+, Zn2+, and Al3+

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12 December 2020

Relationships between Pb-induced changes in neurotransmitter system function and behavioral toxicity.

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12 December 2020

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12 December 2020

Induction of vascular endothelial growth factor in human astrocytes by lead. Involvement of a protein kinase C/activator protein-1 complex-dependent and hypoxia-inducible factor 1-independent signaling pathway

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12 December 2020

Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead.

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12 December 2020

Synaptotagmin I is a molecular target for lead

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12 December 2020

Picomolar concentrations of lead stimulate brain protein kinase C

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12 December 2020

Multiprotein complex signaling and the plasticity problem.

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12 December 2020

Early exposure to lead and juvenile delinquency

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12 December 2020

High-affinity zinc inhibition of NMDA NR1-NR2A receptors.

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12 December 2020

Responses to N-methyl-D-aspartate and kainic acid in cerebellar granule cells of lead-exposed rat pups.

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12 December 2020

Permeability of the blood-brain barrier to lead.

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12 December 2020

Permeation of Pb2+ through calcium channels: fura-2 measurements of voltage- and dihydropyridine-sensitive Pb2+ entry in isolated bovine chromaffin cells

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12 December 2020

The current status of childhood low-level lead toxicity.

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12 December 2020

Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure.

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12 December 2020

A selective decrease of cholinergic muscarinic receptors in the visual cortex of adult rats following developmental lead exposure.

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12 December 2020

Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific.

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12 December 2020

Influence of lead ions on cation permeability in human red cell ghosts

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12 December 2020

Lead blocks LTP by an action not at NMDA receptors

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12 December 2020

N-methyl-D-aspartate receptor subunit changes are associated with lead-induced deficits of long-term potentiation and spatial learning.

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12 December 2020

Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit.

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12 December 2020

Lead inhibition of NMDA channels in native and recombinant receptors.

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12 December 2020

The effects of chronic lead exposure on long-term depression in area CA1 and dentate gyrus of rat hippocampus in vitro

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12 December 2020

Chronic lead exposure alters transthyretin concentration in rat cerebrospinal fluid: the role of the choroid plexus

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12 December 2020

Residual cognitive deficits 50 years after lead poisoning during childhood.

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12 December 2020

Rat hippocampal glutamate and GABA release exhibit biphasic effects as a function of chronic lead exposure level

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12 December 2020

Transthyretin, thyroxine, and retinol-binding protein in human cerebrospinal fluid: effect of lead exposure

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12 December 2020

The use of in vitro methods for hazard characterisation of chemicals

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12 December 2020

Modulation of glycine affinity for NMDA receptors by extracellular Ca2+ in trigeminal neurons.

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12 December 2020

NMDA-receptor channel diversity in the developing cerebellum

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12 December 2020

Subacute Pb exposure during development and unbaited tunnel maze performance in mice.

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12 December 2020

Behavior and neurotoxic consequences of lead on rat brain followed by recovery

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12 December 2020

Hippocampal expression of N-methyl-D-aspartate receptor (NMDAR1) subunit splice variant mRNA is altered by developmental exposure to Pb(2+).

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12 December 2020

Multiple pathways of Pb(2+) permeation in rat cerebellar granule neurones

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12 December 2020

Age-dependent effects of lead on [3H]MK-801 binding to the NMDA receptor-gated ionophore: in vitro and in vivo studies

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12 December 2020

Lead exposure in pheochromocytoma (PC12) cells alters neural differentiation and Sp1 DNA-binding.

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12 December 2020

Pb2(+)-induced secretion from bovine chromaffin cells: fura-2 as a probe for Pb2+.

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12 December 2020

Neuropsychological correlates of low-level lead exposure in school-age children: a prospective study

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12 December 2020

Effects of chronic lead exposure on [3H]MK-801 binding in the brain of rat.

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12 December 2020

Solubility of lead as lead (II) chloride in HEPES-Ringer and artificial seawater (Ca-ASW) solutions

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12 December 2020

Postnatal inorganic lead exposure decreases the number of spontaneously active midbrain dopamine neurons in the rat.

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12 December 2020

LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite.

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12 December 2020

Lead-calcium interactions in cellular lead toxicity.

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12 December 2020

Early lead exposure produces lasting changes in sustained attention, response initiation, and reactivity to errors.

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12 December 2020

Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.

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12 December 2020

Lead uptake in brain capillary endothelial cells: activation by calcium store depletion

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12 December 2020

Exposure to lead elevates induction of zif268 and Arc mRNA in rats after electroconvulsive shock: the involvement of protein kinase C.

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12 December 2020

NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins

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12 December 2020

Effects of chronic lead exposure on glutamate release and uptake in cerebellar cells of rat pups

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12 December 2020

Lead inhibition of N-methyl-D-aspartate receptors containing NR2A, NR2C and NR2D subunits.

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12 December 2020

Low-level lead exposure and children's cognitive function in the preschool years

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12 December 2020

Developmental cholinotoxicity of lead: loss of septal cholinergic neurons and long-term changes in cholinergic innervation of the hippocampus in perinatally lead-exposed rats.

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12 December 2020

Two components of long-term depression are impaired by chronic lead exposure in area CA1 and dentate gyrus of rat hippocampus in vitro

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12 December 2020

Pb2+ inhibits NMDA receptor function at high and low affinity sites: developmental and regional brain expression.

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12 December 2020

Homogeneity of regional brain lead concentrations

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12 December 2020

Modulation by magnesium of the affinity of NMDA receptors for glycine in murine hippocampal neurones

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12 December 2020

Lead enters bovine adrenal medullary cells through calcium channels

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12 December 2020

Pathways of Cadmium Influx in Mammalian Neurons

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12 December 2020

Effects of lead on gene expression

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12 December 2020

Zinc finger proteins as potential targets for toxic metal ions: differential effects on structure and function

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12 December 2020

Glycine-independent and subunit-specific potentiation of NMDA responses by extracellular Mg2+

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12 December 2020

Long-term potentiation in the piriform cortex is blocked by lead

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12 December 2020

Inhibition of brain protein kinase C subtypes by lead

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12 December 2020

Analysis of differential effects of Pb2+ on protein kinase C isozymes

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12 December 2020

Rat hippocampal NMDA receptor binding as a function of chronic lead exposure level

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12 December 2020

Divalent cations modulate N-methyl-D-aspartate receptor function at the glycine site.

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12 December 2020

Intracellular mechanism of Pb(2+)-induced norepinephrine release from bovine chromaffin cells

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12 December 2020

Lead-induced changes in NMDA receptor complex binding: correlations with learning accuracy and with sensitivity to learning impairments caused by MK-801 and NMDA administration.

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12 December 2020

Proteomic analysis of NMDA receptor-adhesion protein signaling complexes

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12 December 2020

Glutamatergic components underlying lead-induced impairments in hippocampal synaptic plasticity.

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12 December 2020

Inhibition by lead of production and secretion of transthyretin in the choroid plexus: its relation to thyroxine transport at blood-CSF barrier

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12 December 2020

Astroglia as metal depots: molecular mechanisms for metal accumulation, storage and release

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12 December 2020

Identifiers

DOI

10.1007/BF03033142

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6 August 2017

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