(Q35169025)

6 August 2017

Colitis-associated neoplasia: molecular basis and clinical translation (English)

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6 August 2017

Sebastian Foersch

1

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PubMed ID

24830703

6 August 2017

Markus F Neurath

series ordinal

2

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6 August 2017

15 May 2014

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Cellular and Molecular Life Sciences

6 August 2017

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6 August 2017

71

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6 August 2017

3523-3535

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6 August 2017

18

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https://scigraph.springernature.com/pub.10.1007/s00018-014-1636-x

6 August 2017

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cites work

Crypt stem cells as the cells-of-origin of intestinal cancer

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12 December 2020

Comparison of genetic alterations in colonic adenoma and ulcerative colitis-associated dysplasia and carcinoma

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12 December 2020

The diagnostic accuracy of chromoendoscopy for dysplasia in ulcerative colitis: meta-analysis of six randomized controlled trials.

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12 December 2020

Intestinal immune responses in wild-type and Apcmin/+ mouse, a model for colon cancer.

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12 December 2020

Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development

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12 December 2020

At the crossroads of inflammation and cancer

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12 December 2020

Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele.

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12 December 2020

Accelerated age-related CpG island methylation in ulcerative colitis

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12 December 2020

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

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12 December 2020

Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease.

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12 December 2020

Lessons from hereditary colorectal cancer

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12 December 2020

Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia.

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12 December 2020

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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12 December 2020

MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha

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12 December 2020

VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer

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12 December 2020

Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease

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12 December 2020

Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies

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12 December 2020

Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and update.

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12 December 2020

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

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12 December 2020

IL-23 promotes tumour incidence and growth

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12 December 2020

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12 December 2020

Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

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12 December 2020

Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis

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12 December 2020

Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis.

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12 December 2020

Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms.

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12 December 2020

Intestinal mucosal inflammation leads to systemic genotoxicity in mice

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12 December 2020

Infliximab for inflammatory bowel disease in Denmark 1999-2005: clinical outcome and follow-up evaluation of malignancy and mortality

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12 December 2020

Advanced endoscopic imaging for diagnosis of Crohn's disease

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12 December 2020

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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12 December 2020

Translating inflammatory bowel disease research into clinical medicine

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12 December 2020

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

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12 December 2020

Twenty years' colonoscopic surveillance of patients with ulcerative colitis. Detection of dysplastic and malignant transformation

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12 December 2020

Studies with IL-10-/- mice: an overview.

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12 December 2020

Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis

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12 December 2020

Review article: the data supporting a role for aminosalicylates in the chemoprevention of colorectal cancer in patients with inflammatory bowel disease

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12 December 2020

Confocal chromoscopic endomicroscopy is superior to chromoscopy alone for the detection and characterisation of intraepithelial neoplasia in chronic ulcerative colitis

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12 December 2020

The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer

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12 December 2020

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

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12 December 2020

CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice.

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12 December 2020

Deacetylase inhibition promotes the generation and function of regulatory T cells.

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12 December 2020

Gut flora in health and disease

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12 December 2020

Ursodeoxycholic acid: Mechanism of action and novel clinical applications

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12 December 2020

Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis

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12 December 2020

Molecular genetic profiles of colitis-associated neoplasms

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12 December 2020

Chemoprevention of colorectal cancer

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12 December 2020

Label-free imaging of inflammatory bowel disease using multiphoton microscopy.

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12 December 2020

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

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12 December 2020

Predictive and protective factors associated with colorectal cancer in ulcerative colitis: A case-control study

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12 December 2020

NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach

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12 December 2020

DNA methylation of colon mucosa in ulcerative colitis patients: correlation with inflammatory status.

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12 December 2020

Autocrine IL-6 signaling: a key event in tumorigenesis?

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12 December 2020

Chemoprevention: risk reduction with medical therapy of inflammatory bowel disease

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12 December 2020

Ulcerative colitis and colorectal cancer. A population-based study

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12 December 2020

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

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12 December 2020

Molecular imaging of VEGF in gastrointestinal cancer in vivo using confocal laser endomicroscopy.

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12 December 2020

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

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12 December 2020

Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation

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12 December 2020

Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine.

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12 December 2020

Cancer genes and the pathways they control

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12 December 2020

Chemically induced mouse models of intestinal inflammation

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12 December 2020

Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice

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12 December 2020

STATs in cancer inflammation and immunity: a leading role for STAT3

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12 December 2020

Colitis-associated cancer: the role of T cells in tumor development.

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12 December 2020

Molecular screening of patients with long standing extensive ulcerative colitis: detection of p53 and Ki-ras mutations by single strand conformation polymorphism analysis and differential hybridisation in colonic lavage fluid

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12 December 2020

Chemoprevention of colon cancer carcinogenesis by balsalazide: inhibition of azoxymethane-induced aberrant crypt formation in the rat colon and intestinal tumor formation in the B6-Min/+ mouse.

1 reference

12 December 2020

Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment

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12 December 2020

Angiogenesis and chronic inflammation: cause or consequence?

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12 December 2020

Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo

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12 December 2020

Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression

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12 December 2020

Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis?

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12 December 2020

The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer.

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12 December 2020

Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease.

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12 December 2020

Cancer prevention in inflammatory bowel disease and the chemoprophylactic potential of 5-aminosalicylic acid

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12 December 2020

Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML

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12 December 2020

The human microbiome: at the interface of health and disease

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12 December 2020

Significance of inflammatory cytokines in the progression of colorectal cancer

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12 December 2020

Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis

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12 December 2020

Chronic inflammation and mutagenesis

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12 December 2020

Chemoprevention of colorectal cancer

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12 December 2020

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

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12 December 2020

High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis

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12 December 2020

Inflammatory bowel disease as a risk factor for colorectal cancer.

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12 December 2020

Interleukin-6--a key regulator of colorectal cancer development.

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12 December 2020

IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

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12 December 2020

Long-term safety of Infliximab for the treatment of inflammatory bowel disease: does blocking TNFalpha reduce colitis-associated colorectal carcinogenesis?

1 reference

12 December 2020

Intestinal inflammation and cancer

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12 December 2020

Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis

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12 December 2020

Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis

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12 December 2020

New insights into the molecular mechanism of interleukin-10-mediated immunosuppression

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12 December 2020

Cancer. p53, guardian of the genome

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12 December 2020

Regulatory T cells in inflammatory bowel diseases and colorectal cancer

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12 December 2020

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

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12 December 2020

MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function

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12 December 2020

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses

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12 December 2020

Decreased production of interleukin-12 and type 2 immune responses are marked in cachectic patients with colorectal and gastric cancer

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12 December 2020

Cancer surveillance in longstanding ulcerative colitis: endoscopic appearances help predict cancer risk.

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12 December 2020

Effector memory T cells, early metastasis, and survival in colorectal cancer

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12 December 2020

Dysplasia and cancer complicating strictures in ulcerative colitis

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12 December 2020

Interleukin-10-deficient mice develop chronic enterocolitis

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12 December 2020

Proinflammatory role of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis: prospects for therapeutic intervention.

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12 December 2020

Experimental models of mucosal inflammation

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12 December 2020

Chromosomal instability in ulcerative colitis is related to telomere shortening

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12 December 2020

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

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12 December 2020

Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: a meta-analysis

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12 December 2020

DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis.

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12 December 2020

Identification of stem cells in small intestine and colon by marker gene Lgr5

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12 December 2020

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.

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12 December 2020

STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction

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12 December 2020

The role of chemoprevention of colorectal cancer with 5-aminosalicylates in ulcerative colitis

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12 December 2020

Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodium-induced murine experimental colitis and human ulcerative colitis.

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12 December 2020

Infliximab for induction and maintenance therapy for ulcerative colitis

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12 December 2020

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

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12 December 2020

APC mutations occur early during colorectal tumorigenesis

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12 December 2020

In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease

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12 December 2020

Radical causes of cancer.

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12 December 2020

Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis.

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12 December 2020

Endomicroscopic Imaging of COX-2 Activity in Murine Sporadic and Colitis-Associated Colorectal Cancer.

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12 December 2020

Inflammatory Bowel Disease

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12 December 2020

Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia

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12 December 2020

5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer

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12 December 2020

Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer

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12 December 2020

Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK

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12 December 2020

Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics.

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12 December 2020

The microbiome and cancer

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12 December 2020

Confocal endomicroscopy in ulcerative colitis: differentiating dysplasia-associated lesional mass and adenoma-like mass

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12 December 2020

Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis

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12 December 2020

Colitis and colorectal cancer

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12 December 2020

Telomere length in the colon declines with age: a relation to colorectal cancer?

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12 December 2020

Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis

1 reference

12 December 2020

THE PROGRESSION TO CARCINOMA OF VIRUS-INDUCED RABBIT PAPILLOMAS (SHOPE)

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12 December 2020

Prevention of colitis-associated carcinogenesis with infliximab.

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12 December 2020

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

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12 December 2020

Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice.

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12 December 2020

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

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12 December 2020

Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.

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12 December 2020

Increased risk of intestinal cancer in Crohn's disease: a meta-analysis of population-based cohort studies

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12 December 2020

Therapeutic targeting of the interleukin-6 receptor.

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12 December 2020

In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptor

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12 December 2020

VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis.

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12 December 2020

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

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12 December 2020

New therapies for inflammatory bowel disease: from the bench to the bedside

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12 December 2020

Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation

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12 December 2020

Intestinal inflammation targets cancer-inducing activity of the microbiota.

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12 December 2020

Roles for inflammation and regulatory T cells in colon cancer

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12 December 2020

Long-term safety of infliximab for the treatment of inflammatory bowel disease: a single-centre cohort study

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12 December 2020

Genetic alterations in the adenoma--carcinoma sequence

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12 December 2020

5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study

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12 December 2020

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

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12 December 2020

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation

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12 December 2020

Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation.

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12 December 2020

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

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12 December 2020

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

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12 December 2020

Therapeutic blockade of interleukin-6 in chronic inflammatory disease

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12 December 2020

AGA technical review on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease.

1 reference

12 December 2020

Colorectal cancer prevention in ulcerative colitis: a case-control study.

1 reference

12 December 2020

The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis

1 reference

12 December 2020

Molecular biology of dysplasia and cancer in inflammatory bowel disease

1 reference

12 December 2020

Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage.

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12 December 2020

10.1007/S00018-014-1636-X

Identifiers

DOI

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6 August 2017

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PubMed ID

24830703