(Q35172084)

6 August 2017

title

PKCε promotes HuD-mediated neprilysin mRNA stability and enhances neprilysin-induced Aβ degradation in brain neurons (English)

1 reference

6 August 2017

Chol Seung Lim

1

1 reference

6 August 2017

Daniel L Alkon

series ordinal

2

1 reference

6 August 2017

language of work or name

English

0 references

publication date

21 May 2014

1 reference

6 August 2017

1 reference

6 August 2017

volume

9

1 reference

6 August 2017

issue

5

1 reference

6 August 2017

page(s)

e97756

1 reference

Creative Commons Attribution 4.0 International

6 August 2017

copyright license

start time

21 May 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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28 July 2018

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28 July 2018

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Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt

28 July 2018

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Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain

28 July 2018

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Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

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Reduction of beta-amyloid levels by novel protein kinase C(epsilon) activators

28 July 2018

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nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing

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28 July 2018

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Neprilysin protects neurons against Abeta peptide toxicity

28 July 2018

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Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway

28 July 2018

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Amyloid beta peptide directly inhibits PKC activation

28 July 2018

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Neprilysin regulates amyloid Beta peptide levels

28 July 2018

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28 July 2018

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Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

28 July 2018

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

28 July 2018

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Cytoplasmic localization is required for the mammalian ELAV-like protein HuD to induce neuronal differentiation

28 July 2018

1 reference

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

28 July 2018

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Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

28 July 2018

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Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0097756

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0097756

PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive deficits in Alzheimer's disease transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0097756

Regulation of mRNA stability in the nervous system and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0097756

Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0097756

Neprilysin content is reduced in Alzheimer brain areas.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029802

Neuroprotective strategies in Alzheimer's disease

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24848988

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24848988

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neprilysin: assay methods, purification, and characterization

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24848988

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0097756

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference