(Q35172250)

6 August 2017

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title

The production and use of cells as therapeutic agents in neurodegenerative diseases (English)

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6 August 2017

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Ole Isacson

1

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PubMed ID

12849120

6 August 2017

language of work or name

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1 July 2003

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6 August 2017

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6 August 2017

2

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6 August 2017

417-424

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6 August 2017

7

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Opinion: neural stem cell therapy for neurological diseases: dreams and reality

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Development of the human striatum: implications for fetal striatal transplantation in the treatment of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Transplantation of embryonic dopamine neurons for severe Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Parkinson's disease: interpretations of transplantation study are erroneous.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Islet mass and function in diabetes and transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Successful islet transplantation: continued insulin reserve provides long-term glycemic control

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Current status of SOD1 mutations in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Genetics of sporadic ALS.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

The genetic and molecular mechanisms of motor neuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Increased survival and function of SOD1 mice after glial cell-derived neurotrophic factor gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Directed differentiation of embryonic stem cells into motor neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

A polymorphic DNA marker genetically linked to Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Huntington's disease and repeating trinucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Relationship between CAG repeat length and late-stage outcomes in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

The enigma of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Striatal grafts provide sustained protection from kainic and quinolinic acid-induced damage

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Time course of the neuroprotective effect of transplantation on quinolinic acid-induced lesions of the striatum

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Striatal implants protect the host striatum against quinolinic acid toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Protective effects of neurotrophin-4/5 and transforming growth factor-alpha on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Neural transplantation for Huntington's disease: experimental rationale and recommendations for clinical trials

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Functional integration of striatal allografts in a primate model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Neural induction, the default model and embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Embryonic stem cells go dopaminergic

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Substantia nigra transplants into denervated striatum of the rat: ultrastructure of graft and host interconnections

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Host afferents into intrastriatal transplants of fetal ventral mesencephalon

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Dopamine-mediated regulation of striatal neuronal and network interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Continuous dopamine-receptor stimulation in advanced Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Autoregulation of dopamine release and metabolism by intrastriatal nigral grafts as revealed by intracerebral dialysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Neural transplantation studies reveal the brain's capacity for continuous reconstruction.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Clinical observations after neural transplantation in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

Normoglycemia after reflux of islet-containing pancreatic fragments into the splenic vascular bed in dogs.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900437-X

7 January 2021

10.1016/S1474-4422(03)00437-X

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12849120