(Q35172770)

6 August 2017

title

HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine development (English)

1 reference

6 August 2017

2

Garnett Kelsoe

1 reference

6 August 2017

3

Barton F Haynes

1 reference

6 August 2017

1

Laurent Verkoczy

1 reference

6 August 2017

publication date

22 May 2014

1 reference

6 August 2017

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6 August 2017

volume

10

1 reference

6 August 2017

issue

5

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6 August 2017

page(s)

e1004073

1 reference

Creative Commons Attribution 4.0 International

6 August 2017

copyright license

start time

22 May 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies

1 reference

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Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10

28 July 2018

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B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

HIV-1 neutralizing antibodies: understanding nature's pathways

28 July 2018

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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

28 July 2018

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Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

28 July 2018

1 reference

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Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies

28 July 2018

1 reference

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Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs

28 July 2018

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

28 July 2018

1 reference

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Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape

28 July 2018

1 reference

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Anti-HIV B Cell lines as candidate vaccine biosensors

28 July 2018

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B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study

28 July 2018

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Antibody-based protection against HIV infection by vectored immunoprophylaxis

28 July 2018

1 reference

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Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation

28 July 2018

1 reference

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Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls

28 July 2018

1 reference

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Induction of immunity to human immunodeficiency virus type-1 by vaccination

28 July 2018

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Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

28 July 2018

1 reference

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Correlates of protection induced by vaccination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance

28 July 2018

1 reference

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Role of HIV membrane in neutralization by two broadly neutralizing antibodies

28 July 2018

1 reference

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Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

28 July 2018

1 reference

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Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Antibody polyspecificity and neutralization of HIV-1: a hypothesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Predominant autoantibody production by early human B cell precursors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Antibody neutralization and escape by HIV-1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

28 July 2018

1 reference

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Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Transgenic mice and analysis of B-cell tolerance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

28 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004073

HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004073

Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004073

Checkpoints in lymphocyte development and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004073

Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004073

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004073

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004073

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031215

Structural vaccinology starts to deliver

27 September 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004073

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004073

Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004073

10.1371/JOURNAL.PPAT.1004073

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

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6 August 2017

1 reference