(Q35174923)

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Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

11

object named as

James M Wilson

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Europe PubMed Central

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6 August 2017

12

object named as

H Lee Sweeney

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Europe PubMed Central

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6 August 2017

Lawrence T Bish

1

object named as

Lawrence T Bish

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Europe PubMed Central

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6 August 2017

2

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Meg M Sleeper

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6 August 2017

author name string

Caryn Reynolds

3

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Europe PubMed Central

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6 August 2017

Jeffrey Gazzara

4

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Europe PubMed Central

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6 August 2017

Elanor Withnall

5

1 reference

Europe PubMed Central

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6 August 2017

Gretchen E Singletary

6

1 reference

Europe PubMed Central

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6 August 2017

George Buchlis

7

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Daniel Hui

8

1 reference

Europe PubMed Central

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6 August 2017

Katherine A High

9

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6 August 2017

Guangping Gao

10

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6 August 2017

publication date

8 June 2011

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Europe PubMed Central

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6 August 2017

Human Gene Therapy

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Europe PubMed Central

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6 August 2017

22

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Europe PubMed Central

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6 August 2017

8

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Europe PubMed Central

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6 August 2017

969-977

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Europe PubMed Central

PubMed publication ID

6 August 2017

Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

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Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.

1 reference

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13 July 2018

MicroRNAs add a new dimension to cardiovascular disease

1 reference

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Promotion of embryonic cortico-cerebral neuronogenesis by miR-124.

1 reference

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MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.

1 reference

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The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selection

1 reference

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MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20

1 reference

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Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial.

1 reference

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Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes

1 reference

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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in canines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Gene therapy in heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

MicroRNAs: novel regulators in cardiac development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Reversing advanced heart failure by targeting Ca2+ cycling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

MicroRNA-133 controls cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Control of stress-dependent cardiac growth and gene expression by a microRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Sarcoplasmic reticulum Ca-ATPase-phospholamban interactions and dilated cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Phospholamban: a crucial regulator of cardiac contractility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

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Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

1 reference

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13 July 2018

Biocompatibility of cardiovascular gene delivery catheters with adenovirus vectors: an important determinant of the efficiency of cardiovascular gene transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

13 July 2018

Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 in the canine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

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Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

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Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic

1 reference

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Expression profiling reveals heightened apoptosis and supports fiber size economy in the murine muscles of mastication

1 reference

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Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

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Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

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Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

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Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

27 September 2018

Highly efficient and specific modulation of cardiac calcium homeostasis by adenovector-derived short hairpin RNA targeting phospholamban

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

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Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy

1 reference

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Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159526

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rAAV-asPLB transfer attenuates abnormal sarcoplasmic reticulum Ca2+ -ATPase activity and cardiac dysfunction in rats with myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21542669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21542669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Enhanced Contractility of the Phospholamban-deficient Mouse Heart Persists with Aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/21542669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac troponin I in the normal dog and cat

1 reference

https://pubmed.ncbi.nlm.nih.gov/21542669

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based on heuristic

inferred from PubMed ID database lookup

Calcium and heart failure: the cycle game

1 reference

https://pubmed.ncbi.nlm.nih.gov/21542669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1089/HUM.2011.035

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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