(Q35184211)

7 August 2017

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title

Insulin granule dynamics in pancreatic beta cells (English)

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7 August 2017

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1

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7 August 2017

Renström E

2

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7 August 2017

publication date

17 July 2003

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7 August 2017

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7 August 2017

volume

46

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7 August 2017

issue

8

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7 August 2017

page(s)

1029-1045

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Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells

7 August 2017

cites work

1 reference

12 December 2020

Rapid ATP-Dependent Priming of Secretory Granules Precedes Ca2+-Induced Exocytosis in Mouse Pancreatic B-Cells

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12 December 2020

Interplay between membrane dynamics, diffusion and swelling pressure governs individual vesicular exocytotic events during release of adrenaline by chromaffin cells.

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12 December 2020

Imaging exocytosis of single insulin secretory granules with evanescent wave microscopy: distinct behavior of granule motion in biphasic insulin release

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12 December 2020

Glucose-induced oscillations of intracellular Ca2+ concentration resembling bursting electrical activity in single mouse islets of Langerhans

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12 December 2020

Increased activity of the glucose cycle in the liver: early characteristic of type 2 diabetes

1 reference

12 December 2020

Inhibition of insulin release by synthetic peptides shows that the H3 region at the C-terminal domain of syntaxin-1 is crucial for Ca(2+)- but not for guanosine 5'-[gamma-thio]triphosphate-induced secretion.

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12 December 2020

The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.

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12 December 2020

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action

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12 December 2020

Emerging roles of presynaptic proteins in Ca++-triggered exocytosis

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12 December 2020

Direct measurement of specific membrane capacitance in neurons

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12 December 2020

Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification

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12 December 2020

A two-compartmental model for insulin secretion

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12 December 2020

CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells

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12 December 2020

Genetic determinants of type 2 diabetes

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12 December 2020

Slow and fast oscillations of cytoplasmic Ca2+ in pancreatic islets correspond to pulsatile insulin release

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12 December 2020

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

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12 December 2020

Dynamics of full fusion during vesicular exocytotic events: release of adrenaline by chromaffin cells

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12 December 2020

5-Hydroxytryptamine transport in cells and secretory granules from a transplantable rat insulinoma

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12 December 2020

Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

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12 December 2020

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12 December 2020

The kinetics of exocytosis and endocytosis in the synaptic terminal of goldfish retinal bipolar cells.

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12 December 2020

Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells.

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12 December 2020

Role of syntaxin in mouse pancreatic beta cells

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12 December 2020

Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells

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12 December 2020

Vesicle pools and Ca2+ microdomains: new tools for understanding their roles in neurotransmitter release

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12 December 2020

Beta-granule transport and exocytosis

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12 December 2020

Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate

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12 December 2020

The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related

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12 December 2020

Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells

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12 December 2020

Disruption of Rab3-calmodulin interaction, but not other effector interactions, prevents Rab3 inhibition of exocytosis

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12 December 2020

Signals and pools underlying biphasic insulin secretion

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12 December 2020

Monitoring of exocytosis and endocytosis of insulin secretory granules in the pancreatic beta-cell line MIN6 using pH-sensitive green fluorescent protein (pHluorin) and confocal laser microscopy

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12 December 2020

GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.

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12 December 2020

Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretion

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12 December 2020

Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells

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12 December 2020

A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic ?-cells

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12 December 2020

ATP-sensitive K+ channels and insulin secretion: their role in health and disease.

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12 December 2020

Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet

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12 December 2020

Single nucleotide polymorphism (D68D, T to C) in the syntaxin 1A gene correlates to age at onset and insulin requirement in Type II diabetic patients

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12 December 2020

The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas

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12 December 2020

Triggering and amplifying pathways of regulation of insulin secretion by glucose

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12 December 2020

Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.

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12 December 2020

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells

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12 December 2020

Ultrastructural morphometry of the pancreatic ?-cell

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12 December 2020

Multiple forms of "kiss-and-run" exocytosis revealed by evanescent wave microscopy

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12 December 2020

Temporally resolved catecholamine spikes correspond to single vesicle release from individual chromaffin cells

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12 December 2020

Glucose metabolism and pulsatile insulin release from isolated islets

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12 December 2020

Mitochondrial function in normal and diabetic beta-cells

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12 December 2020

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells

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12 December 2020

Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells

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12 December 2020

Exocytosis-Endocytosis Coupling in the Pancreatic Beta Cell

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12 December 2020

Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells

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12 December 2020

Motile Events in Pancreatic Endocrine Cells*

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12 December 2020

Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics

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12 December 2020

The exocytotic event in chromaffin cells revealed by patch amperometry.

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12 December 2020

Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.

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12 December 2020

Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells

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12 December 2020

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells

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12 December 2020

Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells

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12 December 2020

Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells

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12 December 2020

Multiple exocytotic pathways in pancreatic beta cells.

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12 December 2020

Detection of exocytosis at individual pancreatic beta cells by amperometry at a chemically modified microelectrode.

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12 December 2020

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone

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12 December 2020

Regulated exocytosis: a novel, widely expressed system.

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12 December 2020

Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera

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12 December 2020

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

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12 December 2020

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion

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12 December 2020

Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin

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12 December 2020

The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and is implicated in insulin exocytosis.

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12 December 2020

Molecular determinants of exocytosis

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12 December 2020

Mechanisms of synaptic vesicle exocytosis

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12 December 2020

The Cell Physiology of Biphasic Insulin Secretion.

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12 December 2020

Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium

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12 December 2020

Alterations of insulin secretion from mouse islets treated with sulphonylureas: perturbations of Ca2+ regulation prevail over changes in insulin content

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12 December 2020

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

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12 December 2020

Regulation of insulin release by calcium

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12 December 2020

Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin.

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12 December 2020

Accumulation of dopamine in mouse pancreatic B-cells following injection of L-DOPA. Localization to secretory granules and inhibition of insulin secretion

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12 December 2020

The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets

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12 December 2020

The genetics of type 2 diabetes

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12 December 2020

Spatio-temporal resolution of exocytosis from individual cells

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12 December 2020

Discrete changes of cell membrane capacitance observed under conditions of enhanced secretion in bovine adrenal chromaffin cells

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12 December 2020

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

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12 December 2020

Diabetes and insulin secretion: whither KATP?

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12 December 2020

Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion

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12 December 2020

Endocytotic mechanisms in synapses

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12 December 2020

Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells

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12 December 2020

Quantal analysis of 5-hydroxytryptamine release from mouse pancreatic beta-cells.

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12 December 2020

Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells

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12 December 2020

Transport, docking and exocytosis of single secretory granules in live chromaffin cells

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12 December 2020

Glucose-induced electrical activity in pancreatic islet cells

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12 December 2020

Amperometric detection of quantal secretion from patch-clamped rat pancreatic beta-cells

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12 December 2020

Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells

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12 December 2020

Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide

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12 December 2020

Effects of intravesicular H+ and extracellular H+ and Zn2+ on insulin secretion in pancreatic beta cells

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12 December 2020

Ca2+-Triggered Peptide Secretion in Single Cells Imaged with Green Fluorescent Protein and Evanescent-Wave Microscopy

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12 December 2020

Involvement of conventional kinesin in glucose-stimulated secretory granule movements and exocytosis in clonal pancreatic beta-cells.

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12 December 2020

Insulin secretory deficiency and glucose intolerance in Rab3A null mice

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12 December 2020

Diabetes mellitus and genetically programmed defects in beta-cell function

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12 December 2020

Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis

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12 December 2020

Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities

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12 December 2020

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12 December 2020

Electrophysiology of the pancreatic beta-cell

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12 December 2020

Down-regulated expression of exocytotic proteins in pancreatic islets of diabetic GK rats

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12 December 2020

Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells

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12 December 2020

Monoamines in the pancreatic islets of the mouse. Subcellular localization of 5-hydroxytryptamine by electron microscopic autoradiography

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12 December 2020

KATP channels gated by intracellular nucleotides and phospholipids

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12 December 2020

ATP-sensitive K+ channel-independent, insulinotropic action of glucose in the B-cells

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12 December 2020

Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins

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12 December 2020

Cycling of synaptic vesicles: how far? How fast!

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12 December 2020

Dynamics of Insulin Secretion by the Perfused Rat Pancreas

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12 December 2020

Comparison of storage- and signal-limited models of pancreatic insulin secretion.

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12 December 2020

Compound exocytosis in voltage-clamped mouse pancreatic beta-cells revealed by carbon fibre amperometry

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12 December 2020

Electrical activity, cAMP concentration, and insulin release in mouse islets of Langerhans

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12 December 2020

The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery

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12 December 2020

Expression and localisation of synaptotagmin isoforms in endocrine beta-cells: their function in insulin exocytosis

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12 December 2020

Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets.

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12 December 2020

Insulin Release by Emiocytosis: Demonstration with Freeze-Etching Technique

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12 December 2020

Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets

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12 December 2020

Simultaneous evanescent wave imaging of insulin vesicle membrane and cargo during a single exocytotic event

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12 December 2020

Adrenaline Release by Chromaffin Cells: Constrained Swelling of the Vesicle Matrix Leads to Full Fusion At the ENS, this work has been supported in part by the CNRS (UMR 8640, Ultimatech and the program "Physique et Chimie du Vivant"), by the ENS, a

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12 December 2020

Sulfonylurea receptors: ABC transporters that regulate ATP-sensitive K(+) channels

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12 December 2020

Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?

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12 December 2020

Comparative biology of Ca2+-dependent exocytosis: implications of kinetic diversity for secretory function.

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12 December 2020

10.1007/S00125-003-1153-1

Identifiers

DOI

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7 August 2017

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