(Q35184715)

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NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation

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scholarly article

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Europe PubMed Central

PubMed publication ID

7 August 2017

NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation (English)

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Europe PubMed Central

PubMed publication ID

7 August 2017

5

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Adah Almutairi

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Europe PubMed Central

PubMed publication ID

7 August 2017

author name string

Arthur G Roberts

1

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Europe PubMed Central

PubMed publication ID

7 August 2017

Sara E A Sjögren

2

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Europe PubMed Central

PubMed publication ID

7 August 2017

Nadezda Fomina

3

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Europe PubMed Central

PubMed publication ID

7 August 2017

Kathy T Vu

4

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Europe PubMed Central

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7 August 2017

James R Halpert

6

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Europe PubMed Central

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7 August 2017

language of work or name

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publication date

4 March 2011

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Europe PubMed Central

PubMed publication ID

7 August 2017

number of pages

12

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inferred from page(s)

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Europe PubMed Central

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7 August 2017

50

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Europe PubMed Central

PubMed publication ID

7 August 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

2123-2134

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel,

1 reference

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Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution

1 reference

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Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes.

1 reference

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Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,

1 reference

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Protein structure modeling with MODELLER

1 reference

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1 reference

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Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme

1 reference

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1 reference

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Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

1 reference

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES

1 reference

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Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro.

1 reference

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Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase.

1 reference

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1 reference

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Use of Voigt lineshape for quantification of in vivo 1H spectra.

1 reference

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1 reference

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Cytochromes P450: their active-site structure and mechanism of oxidation

1 reference

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NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam.

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Inhibition of aminopyrine demethylation and binding to cytochrome P-450 by its main metabolites in rat liver microsomes [proceedings]

1 reference

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1 reference

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Distance-constrained molecular docking by simulated annealing.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of aminopyrine and derivatives in man: in vivo study of monomorphic and polymorphic metabolic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance liquid chromatographic analysis of dipyrone metabolites to study their formation in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a 1-electron oxidation mechanism in N-dealkylation of N,N-dialkylanilines by cytochrome P450 2B1. Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

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Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450

1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

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based on heuristic

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orientation of caffeine within the active site of human cytochrome P450 1A2 based on NMR longitudinal (T1) relaxation measurements

1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some characteristics of hepatic microsomal systems which metabolize aminopyrine in the rat and rabbit

1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. II. Enzymatic demethylation and oxidation of aminopyrine and 4-monomethylaminoantipyrine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paramagnetic probes of macromolecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/21375273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI101797V

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 August 2017

ResearchGate publication ID

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