(Q35186336)

7 August 2017

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title

Innovations in oligonucleotide drug delivery (English)

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7 August 2017

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Melanie A Lysik

1

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PubMed ID

12884243

7 August 2017

Susanna Wu-Pong

series ordinal

2

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PubMed ID

12884243

7 August 2017

language of work or name

English

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publication date

1 August 2003

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Journal of Pharmaceutical Sciences

7 August 2017

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7 August 2017

92

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7 August 2017

8

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7 August 2017

1559-1573

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A pressure-mediated nonviral method for efficient arterial gene and oligonucleotide transfer

7 August 2017

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12 December 2020

Antigene, ribozyme and aptamer nucleic acid drugs: progress and prospects

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12 December 2020

Inhibition of inositol uptake in astrocytes by antisense oligonucleotides delivered by pH-sensitive liposomes

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12 December 2020

Cellular uptake and subcellular distribution of phosphorothioate oligonucleotides into cultured cells

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12 December 2020

Characterization of oligonucleotide transport into living cells

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12 December 2020

Enhanced delivery of synthetic oligonucleotides to human leukaemic cells by liposomes and immunoliposomes

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12 December 2020

Immune effects and mechanisms of action of CpG motifs

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12 December 2020

Minimally modified oligonucleotides - combination of end-capping and pyrimidine-protection

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12 December 2020

Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.

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12 December 2020

Alternative interpretations of the oligonucleotide transport literature: insights from nature

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12 December 2020

Inhibition of HIV replication by immunoliposomal antisense oligonucleotide

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12 December 2020

Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers

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12 December 2020

Suppression of human monocyte tissue factor synthesis by antisense oligodeoxynucleotide

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12 December 2020

Shock waves: a novel method for cytoplasmic delivery of antisense oligonucleotides.

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12 December 2020

Rapid nuclear accumulation of injected oligodeoxyribonucleotides

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12 December 2020

Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells

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12 December 2020

Transdermal transport of DNA antisense oligonucleotides by electroporation

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12 December 2020

Use of Nalpha-Fmoc-cysteine(S-thiobutyl) derivatized oligodeoxynucleotides for the preparation of oligodeoxynucleotide-peptide hybrid molecules.

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12 December 2020

Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

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12 December 2020

Transferrin-polycation conjugates as carriers for DNA uptake into cells

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12 December 2020

Synthesis and binding properties of oligonucleotides carrying nuclear localization sequences

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12 December 2020

Intracellular availability of unmodified, phosphorothioated and liposomally encapsulated oligodeoxynucleotides for antisense activity

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12 December 2020

Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres

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12 December 2020

Parameters controlling topical delivery of oligonucleotides by electroporation

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12 December 2020

CpG oligonucleotides as immune adjuvants

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12 December 2020

Small, but not large, unilamellar liposomes composed of dioleoylphosphatidylethanolamine and oleic acid can be stabilized by human plasma

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12 December 2020

In vivo transfection of melanoma cells by lithotripter shock waves

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12 December 2020

Characteristics of oligonucleotide uptake in human keratinocyte cultures

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12 December 2020

Oligonucleotide-cationic liposome interactions. A physicochemical study

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12 December 2020

Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties.

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12 December 2020

Design of carrier peptide-oligonucleotide conjugates with rapid membrane translocation and nuclear localization properties

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12 December 2020

Efficient cationic lipid-mediated delivery of antisense oligonucleotides into eukaryotic cells: down-regulation of the corticotropin-releasing factor receptor

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12 December 2020

Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels

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12 December 2020

Oligonucleotide biological activity: relationship to the cell cycle and nuclear transport

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12 December 2020

Delivery to cancer cells of antisense L-myc oligonucleotides incorporated in fusogenic, cationic-lipid-reconstituted influenza-virus envelopes (cationic virosomes).

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12 December 2020

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

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12 December 2020

Improved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide

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12 December 2020

An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery

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12 December 2020

Folic acid-polylysine carrier improves efficacy of c-myc antisense oligodeoxynucleotides on human melanoma (M14) cells.

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12 December 2020

Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice

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12 December 2020

Preparation and characterization of antisense oligonucleotide-peptide hybrids containing viral fusion peptides

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12 December 2020

Oligodeoxyribonucleotide phosphorothioate fluxes and localization in hematopoietic cells

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12 December 2020

Novel non-endocytic delivery of antisense oligonucleotides

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12 December 2020

Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway.

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12 December 2020

Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms

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12 December 2020

Development of efficient transient transfection systems for introducing antisense oligonucleotides into human epithelial skin cells

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12 December 2020

Adsorption of oligonucleotides onto polyisohexylcyanoacrylate nanoparticles protects them against nucleases and increases their cellular uptake

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12 December 2020

beta-Cyclodextrin derivatives as carriers to enhance the antiviral activity of an antisense oligonucleotide directed toward a coronavirus intergenic consensus sequence.

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12 December 2020

Oligonucleotides encapsulated in pH sensitive liposomes are efficient toward Friend retrovirus

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12 December 2020

[23] Targeted delivery of antisense oligonucleotides to parenchymal liver cells in vivo

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12 December 2020

Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides

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12 December 2020

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

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12 December 2020

Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers

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12 December 2020

Iontophoretic delivery of oligonucleotides across full thickness hairless mouse skin

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12 December 2020

Development of a sustained-release biodegradable polymer delivery system for site-specific delivery of oligonucleotides: characterization of P(LA-GA) copolymer microspheres in vitro

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12 December 2020

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

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12 December 2020

Cationic liposomes for direct gene transfer in therapy of cancer and other diseases.

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12 December 2020

Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum

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12 December 2020

Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers

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12 December 2020

Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide

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12 December 2020

Pharmacokinetics and blood-brain barrier transport of [3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system

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12 December 2020

Electroporation of synthetic oligodeoxynucleotides: a novel technique for ex vivo bone marrow purging

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12 December 2020

Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties

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12 December 2020

Cationic liposomes mediated delivery of antisense oligonucleotides targeted to HPV 16 E7 mRNA in CaSki cells

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12 December 2020

Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages

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12 December 2020

Inhibition of HIV-1 replication in cultured cells with antisense oligonucleotides encapsulated in immunoliposomes.

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12 December 2020

Ultrasound-mediated transfection of mammalian cells

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12 December 2020

Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol

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12 December 2020

Polyisobutylcyanoacrylate nanocapsules containing an aqueous core for the delivery of oligonucleotides.

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12 December 2020

Protamine-fragment peptides fused to an SV40 nuclear localization signal deliver oligonucleotides that produce antisense effects in prostate and bladder carcinoma cells

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12 December 2020

Synthesis and evaluation of nuclear targeting peptide-antisense oligodeoxynucleotide conjugates

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12 December 2020

Impact of 3'-exonuclease stereoselectivity on the kinetics of phosphorothioate oligonucleotide metabolism

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12 December 2020

Antibody-targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication

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12 December 2020

Electron micrographic studies of transport of oligodeoxynucleotides across eukaryotic cell membranes.

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12 December 2020

Delivery of oligonucleotides into mammalian cells by anionic peptides: comparison between monomeric and dimeric peptides

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12 December 2020

Modified adenovirus penton base protein (UTARVE) as a non-replicating vector for delivery of antisense oligonucleotides with antiviral and/or antineoplastic activity

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12 December 2020

Delivery of an anti-HIV-1 ribozyme into HIV-infected cells via cationic liposomes

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12 December 2020

In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-alpha in rats

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12 December 2020

Antisense c-myc oligonucleotide cellular uptake and activity

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12 December 2020

Downregulation of the p75 neurotrophin receptor in tissue culture and in vivo, using beta-cyclodextrin-adamantane-oligonucleotide conjugates

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12 December 2020

Cyclodextrin derivatives in pharmaceutics

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12 December 2020

Antisense c-myc oligodeoxyribonucleotide cellular uptake

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12 December 2020

Cationic liposomes improve stability and intracellular delivery of antisense oligonucleotides into CaSki cells

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12 December 2020

Progress in antisense technology: the end of the beginning

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12 December 2020

Studies on the mechanism of stabilization of partially phosphorothioated oligonucleotides against nucleolytic degradation

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12 December 2020

Localization of a FITC-labeled phosphorothioate oligodeoxynucleotide in the skin after topical delivery by iontophoresis and electroporation

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12 December 2020

Uptake and intracellular distribution of oligonucleotides vectorized by a PAMAM dendrimer

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12 December 2020

Targeted polynucleotides for inhibition of hepatitis B and C viruses

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12 December 2020

Target cell-specific DNA transfer mediated by a chimeric multidomain protein. Novel non-viral gene delivery system

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12 December 2020

Uptake of oligonucleotides by keratinocytes

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12 December 2020

Absorption enhancing effect of cyclodextrins on intranasally administered insulin in rats

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12 December 2020

Enhanced cellular uptake of oligonucleotides by EGF receptor-mediated endocytosis in A549 cells

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12 December 2020

Antisense oligonucleotide delivery with polyhexylcyanoacrylate nanoparticles as carriers

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12 December 2020

Synthesis and anti-HIV activity of thiocholesteryl-coupled phosphodiester antisense oligonucleotides incorporated into immunoliposomes

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12 December 2020

Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo.

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12 December 2020

Cell cycle-dependent distribution and specific inhibitory effect of vectorized antisense oligonucleotides in cell culture

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12 December 2020

CpG motifs as immune adjuvants

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12 December 2020

Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice

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12 December 2020

Scavenger receptor-mediated delivery of antisense mini-exon phosphorothioate oligonucleotide to Leishmania-infected macrophages. Selective and efficient elimination of the parasite

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12 December 2020

Poly(lactide-co-glycolide) microspheres for the controlled release of oligonucleotide/polyethylenimine complexes

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12 December 2020

Mechanisms of a phosphorothioate oligonucleotide delivery by skin electroporation

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12 December 2020

Modulation of oligonucleotide-induced immune stimulation by cyclodextrin analogs

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12 December 2020

The potential use of cyclodextrins in parenteral formulations

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12 December 2020

An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: initial applications in anti-HIV antisense drug delivery to the brain.

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12 December 2020

Adsorption of antineoplastic drugs to polyalkylcyanoacrylate nanoparticles and their release in calf serum

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12 December 2020

Oligonucleotide targeting to alveolar macrophages by mannose receptor-mediated endocytosis

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12 December 2020

Ultrasound enhances gene expression of liposomal transfection

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12 December 2020

Delivery of c-myb antisense oligodeoxynucleotides to human neuroblastoma cells via disialoganglioside GD(2)-targeted immunoliposomes: antitumor effects.

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12 December 2020

In vivo electroporetic transfer of bcl-2 antisense oligonucleotide inhibits the development of hepatocellular carcinoma in rats

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12 December 2020

Pharmacokinetics and biodistribution of oligonucleotide adsorbed onto poly(isobutylcyanoacrylate) nanoparticles after intravenous administration in mice

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12 December 2020

EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice

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12 December 2020

A comparison of shock wave and sinusoidal-focused ultrasound-induced localized transfection of HeLa cells.

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12 December 2020

Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes

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12 December 2020

Mechanism of oligonucleotide release from cationic liposomes

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12 December 2020

Enhanced rectal absorption and reduced local irritation of the anti-inflammatory drug ethyl 4-biphenylylacetate in rats by complexation with water-soluble beta-cyclodextrin derivatives and formulation as oleaginous suppository

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12 December 2020

Polyalkylcyanoacrylate nanoparticles as polymeric carriers for antisense oligonucleotides

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12 December 2020

DNA uptake stimulating protein from Neurospora crassa enhances DNA and oligonucleotide uptake also in mammalian cells.

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12 December 2020

Intracellular distribution of microinjected antisense oligonucleotides

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12 December 2020

Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates

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12 December 2020

A new liposomal formulation for antisense oligodeoxynucleotides with small size, high incorporation efficiency and good stability

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12 December 2020

A new peptide vector for efficient delivery of oligonucleotides into mammalian cells.

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12 December 2020

Use of cyclodextrin and its derivatives as carriers for oligonucleotide delivery.

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12 December 2020

Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues

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12 December 2020

The uptake and distribution of phosphorothioate oligonucleotides into vascular smooth muscle cells in vitro and in rabbit arteries

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12 December 2020

Identifiers

DOI

10.1002/JPS.10399

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7 August 2017

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PubMed ID

12884243