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Catalytic topoisomerase II inhibitors in cancer therapy.
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1 reference
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Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
Catalytic topoisomerase II inhibitors in cancer therapy
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
author
Alexandre Escargueil
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
author name string
Annette K Larsen
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
Andrzej Skladanowski
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
publication date
1 August 2003
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
published in
Pharmacology & Therapeutics
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
volume
99
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
page(s)
167-181
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
issue
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
cites work
Catalytic inhibitors of DNA topoisomerase II
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Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state.
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7 January 2021
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Topoisomerase II drives DNA transport by hydrolyzing one ATP
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7 January 2021
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Structure and mechanism of DNA topoisomerase II
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7 January 2021
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Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells
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7 January 2021
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Inhibition of type II topoisomerase by fostriecin
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7 January 2021
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Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center
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7 January 2021
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Fixed higher dose schedule of suramin plus hydrocortisone in patients with hormone refractory prostate carcinoma a multicenter Phase II study.
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7 January 2021
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Analysis of a core domain in Drosophila DNA topoisomerase II. Targeting of an antitumor agent ICRF-159.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
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Initial mechanistic studies with merbarone (NSC 336628)
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
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Antitumour Activity in a Series of bisDiketopiperazines
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
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Response to ICRF-159 in cell lines resistant to cleavable complex-forming topoisomerase II inhibitors
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
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Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin.
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Crossref
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The human decatenation checkpoint.
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7 January 2021
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A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells/.
1 reference
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Crossref
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7 January 2021
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Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.
1 reference
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Crossref
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7 January 2021
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Suramin
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Crossref
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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Recruitment of cdc2 kinase by DNA topoisomerase II is coupled to chromatin remodeling
1 reference
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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The predicted beta12-beta13 loop is important for inhibition of PP2Acalpha by the antitumor drug fostriecin
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Merbarone: an antitumor agent entering clinical trials
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Interaction of Coumarin Antibiotics with Fragments of the DNA Gyrase B Protein†
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Toxicity, efficacy, and pharmacology of suramin in adults with recurrent high-grade gliomas
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chromosome condensation induced by fostriecin does not require p34cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novobiocin in combination with high-dose chemotherapy for the treatment of advanced breast cancer: a phase 2 study.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dynamics of chromosomes and microtubules visualized by multiple-wavelength fluorescence imaging in living mammalian cells: effects of mitotic inhibitors on cell cycle progression
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane).
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The effect of dexrazoxane (ICRF-187) on doxorubicin- and daunorubicin-mediated growth inhibition of Chinese hamster ovary cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Control of Malignant Metastases by ICRF 159
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the protective effects against chronic doxorubicin cardiotoxicity and the rates of iron (III) displacement reactions of ICRF-187 and other bisdiketopiperazines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The antitumor drug fostriecin induces vimentin hyperphosphorylation and intermediate filament reorganization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacokinetics of the cardioprotector ADR-529 (ICRF-187) in escalating doses combined with fixed-dose doxorubicin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATPase domain of eukaryotic DNA topoisomerase II. Inhibition of ATPase activity by the anti-cancer drug bisdioxopiperazine and ATP/ADP-induced dimerization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topoisomerase II poisoning by ICRF-193.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MST-16, a novel derivative of bis(2,6-dioxopiperazine), synergistically enhances the antitumor effects of anthracyclines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ICRF-193, a catalytic inhibitor of DNA topoisomerase II, delays the cell cycle progression from metaphase, but not from anaphase to the G1 phase in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The biochemical pharmacology of CI-920, a structurally novel antibiotic with antileukemic activity.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
N-terminal and core-domain random mutations in human topoisomerase II alpha conferring bisdioxopiperazine resistance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: cell cycle arrest and induction of aneuploidy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I and pharmacologic study of the alkylating agent modulator novobiocin in combination with high-dose chemotherapy for the treatment of metastatic breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptosis by dexrazoxane (ICRF-187) through caspases in the absence of c-jun expression and c-Jun NH2-terminal kinase 1 (JNK1) activation in VM-26-resistant CEM cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topoisomerase II inhibitor-induced apoptosis in thymocytes and lymphoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Decreased topoisomerase IIalpha expression confers increased resistance to ICRF-193 as well as VP-16 in mouse embryonic stem cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell line-specific differences in the control of cell cycle progression in the absence of mitosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of DNA topoisomerases and DNA topoisomerase inhibitors in the induction of leukemia cell differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resistance mechanisms associated with altered intracellular distribution of anticancer agents.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of mono-ADP-ribosyltransferase activity during the execution phase of apoptosis prevents apoptotic body formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antimycotic effects of the novel antitumor agents fostriecin (CI-920), PD 113,270 and PD 113,271
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypersensitivity of Ku-deficient cells toward the DNA topoisomerase II inhibitor ICRF-193 suggests a novel role for Ku antigen during the G2 and M phases of the cell cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Long-term administration of oral low-dose topoisomerase II inhibitors, MST-16 and VP-16, for refractory or relapsed non-Hodgkin's lymphoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential sensitivities of recombinant human topoisomerase IIalpha and beta to various classes of topoisomerase II-interacting agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Postincubation with aclarubicin reverses topoisomerase II mediated DNA cleavage, strand breaks, and cytotoxicity induced by VP-16.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topoisomerase II alpha is associated with the mammalian centromere in a cell cycle- and species-specific manner and is required for proper centromere/kinetochore structure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dexrazoxane significantly impairs the induction of doxorubicin resistance in the human leukaemia line, K562
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of the DNA topoisomerase II catalytic inhibitor meso-2,3-bis(3,5-dioxopiperazine-1-yl)butane (ICRF-193), a bisdioxopiperazine derivative, with the conserved region(s) of eukaryotic but not prokaryotic enzyme.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA topoisomerase II as the cellular target of a novel antitumor agent ICRF-193, a bisdioxopiperazine derivative, in Xenopus egg extract.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of Inhibition of Vaccinia DNA Topoisomerase by Novobiocin and Coumermycin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fibroblast growth factors: an epigenetic mechanism of broad spectrum resistance to anticancer drugs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antagonistic effect of aclarubicin on camptothecin induced cytotoxicity: role of topoisomerase I
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900058-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0163-7258(03)00058-5
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
PubMed ID
12888111
1 reference
stated in
Europe PubMed Central
PubMed ID
12888111
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12888111%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
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