(Q35190641)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

A phase 1 trial dose-escalation study of tipifarnib on a week-on, week-off schedule in relapsed, refractory or high-risk myeloid leukemia (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

main subject

phase I clinical trial

0 references

author

Timothy Synold

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

author name string

M H Kirschbaum

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

A S Stein

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

J Tuscano

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

J M Zain

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

L Popplewell

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

C Karanes

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

M R O'Donnell

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

B Pulone

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

A Rincon

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

J Wright

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

P Frankel

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

S J Forman

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

E M Newman

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

publication date

31 May 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

page(s)

1543-1547

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines

2 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

Intermittent dosing of the farnesyl transferase inhibitor tipifarnib (R115777) in advanced malignant solid tumors: a phase I California Cancer Consortium Trial

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

Farnesyl transferase inhibitors in the treatment of breast cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

Clinical development of farnesyltransferase inhibitors in leukemias and myelodysplastic syndrome

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignancies

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3165084

Pharmacokinetics of tipifarnib after oral and intravenous administration in subjects with advanced cancer

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21625235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clinical and pharmacologic study of the farnesyltransferase inhibitor tipifarnib in cancer patients with normal or mildly or moderately impaired hepatic function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21625235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21625235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/LEU.2011.124

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21625235%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

21625235

1 reference