(Q41094489)

26 September 2017

1 reference

title

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras? (English)

1 reference

26 September 2017

A D Cox

1

1 reference

PubMed ID

9294018

26 September 2017

C J Der

series ordinal

2

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26 September 2017

1 August 1997

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Biochimica et Biophysica Acta

26 September 2017

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26 September 2017

1333

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26 September 2017

F51-71

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26 September 2017

1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

26 September 2017

1 reference

7 January 2021

The Ras signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Aberrant function of the Ras signal transduction pathway in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Triggering signaling cascades by receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

A genetic model for colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Cooperation between oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Lessons from hereditary colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Anti-Ras drugs come of age.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

The GTPase superfamily: conserved structure and molecular mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Proteins regulating Ras and its relatives

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Structural differences between a ras oncogene protein and the normal protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

The pathway to signal achievement

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Two distinct Raf domains mediate interaction with Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Multiple Ras functions can contribute to mammalian cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

An essential role for Rac in Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

A role for Rho in Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Posttranslational modification of proteins by isoprenoids in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Protein prenylation: more than just glue?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Lipid modifications and function of the ras superfamily of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

All ras proteins are polyisoprenylated but only some are palmitoylated

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Polylysine domain of K-ras 4B protein is crucial for malignant transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Inhibitors of Ras farnesyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Use of yeast for identification of farnesyltransferase inhibitors and for generation of mutant farnesyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Farnesyl transferase inhibitors: the successes and surprises of a new class of potential cancer chemotherapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Cellular Transforming Genes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Biological assays for cellular transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

TC21 causes transformation by Raf-independent signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Predisposition to neoplastic transformation caused by gene replacement of H-ras1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Mutagenesis of active site residues in type I dehydroquinase from Escherichia coli. Stalled catalysis in a histidine to alanine mutant.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

p21ras is modified by a farnesyl isoprenoid

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Rho family members: activators of MAP kinase cascades.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Sp1 is phosphorylated and its DNA binding activity down-regulated upon terminal differentiation of the liver

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Post-translational modification of human brain type I inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Regulation of the mevalonate pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Identification of a nuclear receptor that is activated by farnesol metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Interaction of transforming growth factor-beta receptor I with farnesyl-protein transferase-alpha in yeast and mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

Identification of Ras farnesyltransferase inhibitors by microbial screening

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900011-5

7 January 2021

10.1016/S0304-419X(97)00011-5

Identifiers

DOI

1 reference

26 September 2017

1 reference

PubMed ID

9294018