(Q40445366)

20 September 2017

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title

Aberrant function of the Ras signal transduction pathway in human breast cancer (English)

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20 September 2017

G J Clark

1

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20 September 2017

C J Der

series ordinal

2

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20 September 2017

language of work or name

English

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publication date

1 July 1995

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Breast Cancer Research and Treatment

20 September 2017

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20 September 2017

35

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20 September 2017

133-144

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20 September 2017

1

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https://scigraph.springernature.com/pub.10.1007/bf00694753

20 September 2017

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cites work

Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression

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Crossref

https://api.crossref.org/works/10.1007%2FBF00694753

R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells

21 January 2018

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12 December 2020

R-ras interacts with rasGAP, neurofibromin and c-raf but does not regulate cell growth or differentiation

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12 December 2020

Pathways of Ras function: connections to the actin cytoskeleton.

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12 December 2020

Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function

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12 December 2020

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12 December 2020

The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation

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12 December 2020

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway

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12 December 2020

Quantitation of Harvey ras p21 enhanced expression in human breast and colon carcinomas

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12 December 2020

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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12 December 2020

Oncogene activation in malignant transformation: a study of H-ras in human breast cancer

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12 December 2020

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

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12 December 2020

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

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12 December 2020

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

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12 December 2020

Protein prenylation: more than just glue?

1 reference

12 December 2020

Small GTP-binding proteins and their role in transport

1 reference

12 December 2020

The molecular genetics of cancer

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12 December 2020

The mitogen-activated protein kinase signal transduction pathway

1 reference

12 December 2020

Quantitation of prenylcysteines by a selective cleavage reaction

1 reference

12 December 2020

Signal transduction via the MAP kinases: proceed at your own RSK.

1 reference

12 December 2020

Emerging concepts in the Ras superfamily of GTP-binding proteins.

1 reference

12 December 2020

The PH domain: a common piece in the structural patchwork of signalling proteins

1 reference

12 December 2020

17 beta-estradiol regulates and v-Ha-ras transfection constitutively enhances MCF7 breast cancer cell interactions with basement membrane

1 reference

12 December 2020

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

12 December 2020

A signal chain of events

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12 December 2020

Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling

1 reference

12 December 2020

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

12 December 2020

Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

1 reference

12 December 2020

Anti-Ras drugs come of age.

1 reference

12 December 2020

Oncogenes and signal transduction

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12 December 2020

Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor

1 reference

12 December 2020

Activation of Raf as a result of recruitment to the plasma membrane

1 reference

12 December 2020

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

1 reference

12 December 2020

Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.

1 reference

12 December 2020

Bcl-2 associates with the ras-related protein R-ras p23

1 reference

12 December 2020

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

1 reference

12 December 2020

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

1 reference

12 December 2020

The GTPase superfamily: a conserved switch for diverse cell functions

1 reference

12 December 2020

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

12 December 2020

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.

1 reference

12 December 2020

Molecular themes in oncogenesis

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12 December 2020

Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences

1 reference

12 December 2020

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1 reference

12 December 2020

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide

1 reference

12 December 2020

Signal transduction. How receptors turn Ras on.

1 reference

12 December 2020

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells

1 reference

12 December 2020

Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics

1 reference

12 December 2020

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

1 reference

12 December 2020

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

12 December 2020

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

1 reference

12 December 2020

Transformation of human breast epithelial cells by c-Ha-ras oncogene

1 reference

12 December 2020

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

1 reference

12 December 2020

Ras C-terminal processing enzymes--new drug targets?

1 reference

12 December 2020

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1 reference

12 December 2020

Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10

1 reference

12 December 2020

Triggering signaling cascades by receptor tyrosine kinases

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12 December 2020

The GTPase superfamily: conserved structure and molecular mechanism

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12 December 2020

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12 December 2020

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1 reference

12 December 2020

Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line

1 reference

12 December 2020

Identification of geranylgeranyl-modified proteins in HeLa cells

1 reference

12 December 2020

Sequential protein kinase reactions controlling cell growth and differentiation

1 reference

12 December 2020

Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis

1 reference

12 December 2020

ras oncogenes in human cancer: a review

1 reference

12 December 2020

SH2 domains recognize specific phosphopeptide sequences

1 reference

12 December 2020

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1 reference

12 December 2020

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

1 reference

12 December 2020

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

1 reference

12 December 2020

Non-nuclear oncogenes and the regulation of gene expression in transformed cells.

1 reference

12 December 2020

Immunocytochemical and biochemical analysis of epidermal growth factor receptor expression in human breast cancer tissues: relationship to estrogen receptor and lymphatic invasion

1 reference

12 December 2020

Complex formation between RAS and RAF and other protein kinases

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12 December 2020

Structural basis for the binding of proline-rich peptides to SH3 domains

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12 December 2020

Proteins regulating Ras and its relatives

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12 December 2020

Protein prenylation: key to ras function and cancer intervention?

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12 December 2020

Inhibition of Fos- and Ras-induced transformation by mutant Fos proteins with structural alterations in functionally different domains.

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12 December 2020

Biochemistry of protein prenylation

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12 December 2020

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

1 reference

12 December 2020

Mammalian Ras interacts directly with the serine/threonine kinase Raf

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12 December 2020

Transformation and transactivation suppressor activity of the c-Jun leucine zipper fused to a bacterial repressor

1 reference

12 December 2020

The Ras signal transduction pathway

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12 December 2020

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12 December 2020

Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours

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12 December 2020

ras and GAP--who's controlling whom?

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12 December 2020

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase.

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12 December 2020

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

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12 December 2020

The Saccharomyces cerevisiae gene product SDC25 C-domain functions as an oncoprotein in NIH3T3 cells.

1 reference

12 December 2020

Ras p21: effects and regulation

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12 December 2020

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12 December 2020

Regulatory mechanisms for ras proteins

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12 December 2020

Independent molecular pathways in initiation and loss of hormone responsiveness of breast carcinomas.

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12 December 2020

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

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12 December 2020

GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents

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12 December 2020

Signalling through SH2 and SH3 domains

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12 December 2020

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

1 reference

12 December 2020

A putative modular domain present in diverse signaling proteins

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12 December 2020

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

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12 December 2020

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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12 December 2020

MAP kinase regulation--the oncogene connection

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12 December 2020

Prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer.

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12 December 2020

Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein

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12 December 2020

Extracellular signals and reversible protein phosphorylation: what to Mek of it all.

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00694753

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Dimensions Publication ID

20 September 2017

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