(Q35193741)

7 August 2017

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title

The relevance of alternative RNA splicing to pharmacogenomics (English)

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7 August 2017

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Laurent Bracco

1

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7 August 2017

Jonathan Kearsey

series ordinal

2

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7 August 2017

publication date

1 August 2003

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7 August 2017

published in

Trends in Biotechnology

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7 August 2017

volume

21

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7 August 2017

issue

8

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7 August 2017

page(s)

346-353

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Prospective CYP2D6 genotyping as an exclusion criterion for enrollment of a phase III clinical trial

7 August 2017

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Predictive identification of exonic splicing enhancers in human genes

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7 January 2021

The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation

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Signal-dependent regulation of splicing via phosphorylation of Sam68

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7 January 2021

Regulatory functions of 3'UTRs.

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7 January 2021

Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing

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7 January 2021

Pre-mRNA splicing and human disease

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7 January 2021

A genomic view of alternative splicing

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7 January 2021

Different site, different splice

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Ligand binding properties of binary complexes of heparin and immunoglobulin-like modules of FGF receptor 2.

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Down-regulation of (IIIb) and (IIIc) isoforms of fibroblast growth factor receptor 2 (FGFR2) is associated with malignant progression in human prostate

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7 January 2021

Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB).

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Listening to silence and understanding nonsense: exonic mutations that affect splicing

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7 January 2021

Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1.

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7 January 2021

Splicing defects in the ataxia-telangiectasia gene, ATM: underlying mutations and consequences

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7 January 2021

Splicing 2002: RNA splicing in human pathology

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7 January 2021

Defects in pre-mRNA processing as causes of and predisposition to diseases

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Alternative splicing patterns of CYP2D genes in human brain and neurodegenerative disorders

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7 January 2021

Alternative splicing of CYP2D mRNA in human breast tissue

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7 January 2021

Intergenic mRNA molecules resulting from trans-splicing

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7 January 2021

Human deoxycytidine kinase is located in the cell nucleus

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7 January 2021

Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy

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7 January 2021

Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells

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7 January 2021

Deletion mutants of human deoxycytidine kinase mRNA in cells resistant to antitumor cytosine nucleosides

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7 January 2021

Modification of alternative splicing pathways as a potential approach to chemotherapy

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7 January 2021

Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression

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7 January 2021

Spatially distributed alternative splice variants of the renal Na-K-Cl cotransporter exhibit dramatically different affinities for the transported ions.

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7 January 2021

Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization

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7 January 2021

Alternative RNA splicing in the nervous system

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7 January 2021

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity

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7 January 2021

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression

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7 January 2021

Dopamine D2S and D2L receptors may differentially contribute to the actions of antipsychotic and psychotic agents in mice

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7 January 2021

Dopamine D2 receptor-mediated inhibition of dopaminergic neurons in mice lacking D2L receptors

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7 January 2021

Spinal pretreatment with antisense oligodeoxynucleotides against exon-1, -4, or -8 of mu-opioid receptor clone leads to differential loss of spinal endomorphin-1-and endomorphin-2-induced antinociception in the mouse

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7 January 2021

C-terminal splice variants of the mouse mu-opioid receptor differ in morphine-induced internalization and receptor resensitization

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7 January 2021

Expression of mRNAs encoding flip isoforms of GluR1 and GluR2 glutamate receptors is increased in rat hippocampus in epilepsy induced by tetanus toxin

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7 January 2021

Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis

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7 January 2021

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

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7 January 2021

Structural determinants of allosteric regulation in alternatively spliced AMPA receptors.

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7 January 2021

The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists.

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7 January 2021

Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins

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7 January 2021

Nitric oxide synthases: structure, function and inhibition

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7 January 2021

High CA repeat numbers in intron 13 of the endothelial nitric oxide synthase gene and increased risk of coronary artery disease.

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7 January 2021

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

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7 January 2021

Gene expression profiling predicts clinical outcome of breast cancer

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7 January 2021

Initial sequencing and analysis of the human genome

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7 January 2021

Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology

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7 January 2021

Experimental annotation of the human genome using microarray technology

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7 January 2021

Predicting splice variant from DNA chip expression data

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7 January 2021

Qualitative gene profiling: a novel tool in genomics and in pharmacogenomics that deciphers messenger RNA isoforms diversity.

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7 January 2021

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

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7 January 2021

Bcl-x(S) anatagonizes the protective effects of Bcl-x(L).

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7 January 2021

Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemia

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7 January 2021

A novel splice variant of the cell death-promoting protein BAX.

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7 January 2021

Bim: a novel member of the Bcl-2 family that promotes apoptosis

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7 January 2021

Bcl-G, a novel pro-apoptotic member of the Bcl-2 family

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7 January 2021

MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain

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7 January 2021

Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death

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7 January 2021

Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade

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7 January 2021

Alternative splicing and programmed cell death

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7 January 2021

Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter

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7 January 2021

Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas

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7 January 2021

Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis

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7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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7 January 2021

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

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7 January 2021

IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival

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7 January 2021

STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

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7 January 2021

Differential influence of etoposide on two caspase-2 mRNA isoforms in leukemic cells.

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7 January 2021

Opposing actions of adrenal androgens and glucocorticoids on alternative splicing of Slo potassium channels in bovine chromaffin cells

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7 January 2021

Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients

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7 January 2021

Ethanol regulates calcium channel subunits by protein kinase C delta -dependent and -independent mechanisms.

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7 January 2021

Beta-amyloid precursor protein (APP) and APP-RNA are rapidly affected by glutamate in cultured neurons: selective increase of mRNAs encoding a Kunitz protease inhibitor domain.

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7 January 2021

10.1016/S0167-7799(03)00146-X

Identifiers

DOI

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7 August 2017

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