(Q35209127)

7 August 2017

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title

The biology of IL-12: coordinating innate and adaptive immune responses (English)

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7 August 2017

interleukin-12 complex

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Gene Ontology release 2020-05-02

Wendy T Watford

1

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7 August 2017

Masato Moriguchi

series ordinal

2

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7 August 2017

Akio Morinobu

series ordinal

3

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7 August 2017

John J O'Shea

series ordinal

4

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7 August 2017

language of work or name

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1 October 2003

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Cytokine and Growth Factor Reviews

7 August 2017

1 reference

7 August 2017

14

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7 August 2017

5

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7 August 2017

361-368

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Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

7 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Regulation of interleukin 12 p40 expression through an NF-kappa B half-site

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Toll-like receptors and innate immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Control of adaptive immune responses by Toll-like receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Toll-like receptors: critical proteins linking innate and acquired immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IFN-gamma induces IL-12 mRNA expression by a murine macrophage cell line, J774.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IL-4 pretreatment selectively enhances cytokine and chemokine production in lipopolysaccharide-stimulated mouse peritoneal macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Positive and negative regulation of pathogen induced dendritic cell function by G-protein coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

SYNERGISTIC PROLIFERATION AND ACTIVATION OF NATURAL KILLER CELLS BY INTERLEUKIN 12 AND INTERLEUKIN 18

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IFN-gamma production by antigen-presenting cells: mechanisms emerge.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

1 reference

7 January 2021

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Regulation of T(H)1 differentiation--controlling the controllers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

T helper subset development: roles of instruction, selection, and transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Transcription: tantalizing times for T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Jaks and STATs: biological implications

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Phosphorylation of src Family lck Tyrosine Kinase Following Interleukin-12 Activation of Human Natural Killer Cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-gamma expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Cytokine regulation of IL-12 receptor beta2 expression: differential effects on human T and NK cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IL-23: a cytokine that acts on memory T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Inherited disorders of IL-12- and IFNγ-mediated immunity: a molecular genetics update

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Reduced IFNgamma production in response to IL-12 stimulation and/or reduced IL-12 production in atopic patients

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Atopy and mutations of IL-12 receptor beta 2 chain gene

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Jak2 is essential for signaling through a variety of cytokine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Partial impairment of cytokine responses in Tyk2-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900043-1

7 January 2021

10.1016/S1359-6101(03)00043-1

Identifiers

DOI

1 reference

7 August 2017

1 reference