(Q35209965)

7 August 2017

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title

The development and regulation of gene repair (English)

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7 August 2017

Li Liu

1

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PubMed ID

12951569

7 August 2017

Hetal Parekh-Olmedo

series ordinal

2

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PubMed ID

12951569

7 August 2017

Eric B Kmiec

series ordinal

3

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7 August 2017

1 September 2003

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7 August 2017

Nature Reviews Genetics

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7 August 2017

4

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7 August 2017

9

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7 August 2017

679-689

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https://scigraph.springernature.com/pub.10.1038/nrg1156

7 August 2017

0 references

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A role for RNA synthesis in homologous pairing events

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RNA facilitates RecA-mediated DNA pairing and strand transfer between molecules bearing limited regions of homology

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The synaptic complex of RecA protein participates in hybridization and inverse strand exchange reactions

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Rad51p and Rad54p, but not Rad52p, elevate gene repair in Saccharomyces cerevisiae directed by modified single-stranded oligonucleotide vectors

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Strand bias in targeted gene repair is influenced by transcriptional activity

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DNA hybrids stabilized by heterologies

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DNA pairing is an important step in the process of targeted nucleotide exchange

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Opportunities and challenges in targeting genes for therapy

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In vitro correction of cystic fibrosis epithelial cell lines by small fragment homologous replacement (SFHR) technique.

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Harmful potential of viral vectors fuels doubts over gene therapy

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Mechanisms underlying targeted gene correction using chimeric RNA/DNA and single-stranded DNA oligonucleotides

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Optimising gene repair strategies in cell culture

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Functional correction of episomal mutations with short DNA fragments and RNA-DNA oligonucleotides.

21 January 2018

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Gene targeting is enhanced in human cells overexpressing hRAD51.

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Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing

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Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration

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Mammalian DNA mismatch repair

21 January 2018

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Eukaryotic DNA mismatch repair

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In vitro and in vivo nucleotide exchange directed by chimeric RNA/DNA oligonucleotides in Saccharomyces cerevisae

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Nucleotide excision repair in mammalian cells

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Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry

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Recombination induced by triple-helix-targeted DNA damage in mammalian cells

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Triple helix directed psoralen adducts induce a low frequency of recombination in an SV40 shuttle vector

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Short, single-stranded oligonucleotides mediate targeted nucleotide conversion using extracts from isolated liver mitochondria

21 January 2018

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Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides

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Re-engineering plant gene targeting

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21 January 2018

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Mitochondria isolated from liver contain the essential factors required for RNA/DNA oligonucleotide-targeted gene repair

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Chloroplast lysates support directed mutagenesis via modified DNA and chimeric RNA/DNA oligonucleotides

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21 January 2018

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31 March 2020

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31 March 2020

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Transcription activates RecA-promoted homologous pairing of nucleosomal DNA.

31 March 2020

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Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids

31 March 2020

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In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement

31 March 2020

1 reference

Influence of DNA delivery method on gene targeting frequencies in human cells

31 March 2020

1 reference

Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament

31 March 2020

1 reference

Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

31 March 2020

1 reference

DNA mismatch correction in a defined system

31 March 2020

1 reference

Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide

31 March 2020

1 reference

Targeted gene conversion in a mammalian CD34+-enriched cell population using a chimeric RNA/DNA oligonucleotide

31 March 2020

1 reference

Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide

31 March 2020

1 reference

Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide

31 March 2020

1 reference

In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides

31 March 2020

1 reference

Nucleotide exchange in genomic DNA of rat hepatocytes using RNA/DNA oligonucleotides. Targeted delivery of liposomes and polyethyleneimine to the asialoglycoprotein receptor

31 March 2020

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Homologous recombination based gene therapy

31 March 2020

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In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide

31 March 2020

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Persistent failures in gene repair

31 March 2020

1 reference

Recombinant DNA technique and sickle cell anemia research

31 March 2020

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31 March 2020

Gene repair validation

1 reference

Enhanced gene transfer into HuH-7 cells and primary rat hepatocytes using targeted liposomes and polyethylenimine

31 March 2020

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Analysis of the binding of p53 to DNAs containing mismatched and bulged bases

31 March 2020

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Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors

31 March 2020

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High-affinity triple helix formation by synthetic oligonucleotides at a site within a selectable mammalian gene.

31 March 2020

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High-efficiency triple-helix-mediated photo-cross-linking at a targeted site within a selectable mammalian gene

31 March 2020

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The many faces of chromatin remodeling: SWItching beyond transcription

31 March 2020

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Correction/mutation of acid α-D-glucosidase gene by modified single-stranded oligonucleotides: in vitro and in vivo studies

31 March 2020

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Genetic repair of mutations in plant cell-free extracts directed by specific chimeric oligonucleotides

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1156

1 reference

7 August 2017

1 reference

PubMed ID

12951569