(Q35213298)

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CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21771791%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21771791%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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Alzheimer's disease

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2

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8 February 2020

Tiina M. Kauppinen

4

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8 February 2020

6

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8 February 2020

Richard M Ransohoff

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Richard M Ransohoff

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8 February 2020

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Seo-Hyun Cho

1

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8 February 2020

Yungui Zhou

3

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8 February 2020

Brian Halabisky

5

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8 February 2020

Li Gan

8

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8 February 2020

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publication date

19 July 2011

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8 February 2020

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10

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Journal of Biological Chemistry

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8 February 2020

286

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8 February 2020

37

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8 February 2020

32713-32722

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Europe PubMed Central

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8 February 2020

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3173153/fullTextXML

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

The myeloid cells of the central nervous system parenchyma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network

1 reference

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13 July 2018

Regulation of tau pathology by the microglial fractalkine receptor

1 reference

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13 July 2018

CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.

1 reference

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13 July 2018

Genome-wide analysis of genetic loci associated with Alzheimer disease

1 reference

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13 July 2018

Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior

1 reference

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13 July 2018

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

1 reference

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13 July 2018

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

1 reference

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13 July 2018

Does neuroinflammation fan the flame in neurodegenerative diseases?

1 reference

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13 July 2018

Inflammation, microglia, and Alzheimer's disease

1 reference

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13 July 2018

Heterogeneity of microglial activation in the innate immune response in the brain

1 reference

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13 July 2018

The liberation of fractalkine in the dorsal horn requires microglial cathepsin S.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Microglial physiology: unique stimuli, specialized responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues

1 reference

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13 July 2018

Recognition memory and the medial temporal lobe: a new perspective

1 reference

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13 July 2018

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Control of microglial neurotoxicity by the fractalkine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Microglia as a potential bridge between the amyloid beta-peptide and tau.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

1 reference

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13 July 2018

Inflammation in neurodegenerative disease--a double-edged sword

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Recognition memory: what are the roles of the perirhinal cortex and hippocampus?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion

1 reference

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13 July 2018

Macrophage surface glycoproteins binding to galectin-3 (Mac-2-antigen).

1 reference

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13 July 2018

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

13 July 2018

Inflammation and Alzheimer's disease pathogenesis

1 reference

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13 July 2018

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

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13 July 2018

Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.

1 reference

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26 September 2018

Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

26 September 2018

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

26 September 2018

Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

26 September 2018

Interleukin-6: a cytokine to forget

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

26 September 2018

Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

26 September 2018

Production and neuroprotective functions of fractalkine in the central nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173153

26 September 2018

Immunocytochemical evidence that amyloid beta (1-42) impairs endogenous antioxidant systems in vivo

1 reference

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26 September 2018

Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6.

1 reference

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26 September 2018

Identifiers

10.1074/JBC.M111.254268

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21771791%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21771791%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21771791%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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