(Q35214667)

7 August 2017

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title

Signaling to migration in neutrophils: importance of localized pathways (English)

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7 August 2017

Verena Niggli

1

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7 August 2017

publication date

1 December 2003

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International Journal of Biochemistry & Cell Biology

7 August 2017

published in

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7 August 2017

volume

35

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7 August 2017

issue

12

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7 August 2017

page(s)

1619-1638

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Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils

7 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Integrin signalling in neutrophils and macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

PKB binding proteins. Getting in on the Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Phosphoinositide 3-kinase modulation of beta(3)-integrin represents an endogenous "braking" mechanism during neutrophil transmatrix migration

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Role of p38 mitogen-activated protein kinase in chemokine-induced emigration and chemotaxis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Chemoattractant receptor-stimulated F-actin polymerization in the human neutrophil is signaled by 2 distinct pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Chemotactic signaling pathways in neutrophils: from receptor to actin assembly

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Okadaic acid: a new probe for the study of cellular regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Myosin X is a downstream effector of PI(3)K during phagocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Modulation of the chemotactic responsiveness of guinea pig neutrophils to hrIL-8 and fMLP.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Signaling pathways involved in dephosphorylation and localization of the actin-binding protein cofilin in stimulated human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Intracellular signaling in neutrophil priming and activation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Potential role of IL-8, platelet-activating factor and TNF-alpha in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

T lymphocytes and neutrophil granulocytes differ in regulatory signaling and migratory dynamics with regard to spontaneous locomotion and chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Phosphorylation-independent association of CXCR2 with the protein phosphatase 2A core enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in Zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

C-reactive protein inhibits chemotactic peptide-induced p38 mitogen-activated protein kinase activity and human neutrophil movement

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

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https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Calyculin A and okadaic acid: inhibitors of protein phosphatase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Selective effects of the PKC inhibitors Ro 31-8220 and CGP 41,251 on PMN locomotion, cell polarity, and pinocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Altered responsiveness to chemokines due to targeted disruption of SHIP.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Differential effects of a mitogen-activated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activate

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

MAP kinase upregulation after hematopoietic differentiation: role of chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Requirement for RhoA kinase activation in leukocyte de-adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Calcium and signal transduction in granulocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Attachment to fibronectin or vitronectin makes human neutrophil migration sensitive to alterations in cytosolic free calcium concentration

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

The involvement of calcium and protein kinase C in modulating agonist-stimulated chemotaxis of human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Syk is required for integrin signaling in neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Intracellular acidification, guanine-nucleotide binding proteins, and cytoskeletal actin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase gamma

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

A membrane-permeant ester of phosphatidylinositol 3,4, 5-trisphosphate (PIP(3)) is an activator of human neutrophil migration

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Microtubule-disruption-induced and chemotactic-peptide-induced migration of human neutrophils: implications for differential sets of signalling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Stimulus-induced selective association of actin-associated proteins (alpha-actinin) and protein kinase C isoforms with the cytoskeleton of human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Inhibition of chemotactic peptide-induced development of cell polarity and locomotion by the protein kinase C inhibitor CGP 41 251 in human neutrophils correlates with inhibition of protein phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Membrane lipid organization is critical for human neutrophil polarization.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

An unexplained sequestration of latrunculin A is required in neutrophils for inhibition of actin polymerization.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Rho family proteins: coordinating cell responses

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Cytoskeleton-dependent membrane domain segregation during neutrophil polarization

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Phorbol 12-myristate 13-acetate activates rabbit neutrophils without an apparent rise in the level of intracellular free calcium

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Phorbol ester induces rapid actin assembly in neutrophil leucocytes independently of changes in [Ca2+]i and pHi

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Functional rafts in cell membranes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Cell adhesion and migration properties of beta 2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Roles of PI3Ks in leukocyte chemotaxis and phagocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Rho family GTPases: more than simple switches

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Modulation of Mac-1 (CD11b/CD18)-mediated adhesion by the leukocyte-specific protein 1 is key to its role in neutrophil polarization and chemotaxis.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Spatiotemporal regulation of moesin phosphorylation and rear release by Rho and serine/threonine phosphatase during neutrophil migration.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

Calphostin C induces AP1 synthesis and AP1-dependent c-jun transactivation in normal human chondrocytes independent of protein kinase C-alpha inhibition: possible role for c-jun N-terminal kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900144-4

7 January 2021

10.1016/S1357-2725(03)00144-4

Identifiers

DOI

1 reference

7 August 2017

1 reference