(Q34990565)

5 August 2017

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title

PKB binding proteins. Getting in on the Akt. (English)

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5 August 2017

2

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5 August 2017

3

Brian A Hemmings

1 reference

5 August 2017

Derek P Brazil

1

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PubMed ID

12419241

5 August 2017

language of work or name

English

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publication date

1 November 2002

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5 August 2017

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5 August 2017

111

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5 August 2017

293-303

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5 August 2017

3

1 reference

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Role of translocation in the activation and function of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

A constitutively active version of the Ser/Thr kinase Akt induces production of the ob gene product, leptin, in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Insulin increases the association of Akt-2 with Glut4-containing vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Molecular genetic advances in tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt participation in the Wnt signaling pathway through Dishevelled

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Cdc37: a protein kinase chaperone?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

PKB/Akt interacts with inosine-5' monophosphate dehydrogenase through its pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Role for the adaptor protein Grb10 in the activation of Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

The pleckstrin homology domain of RAC protein kinase associates with the regulatory domain of protein kinase C zeta

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Activation of protein kinase B induced by H(2)O(2) and heat shock through distinct mechanisms dependent and independent of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

The protooncogene TCL1 is an Akt kinase coactivator

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Interaction of Btk and Akt in B cell signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Modulation of cell proliferation by cytokeratins K10 and K16

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Identification of 14-3-3zeta as a protein kinase B/Akt substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Modulation of Akt kinase activity by binding to Hsp90

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

PKB/AKT: functional insights from genetic models

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Identification of myosin II as a binding protein to the PH domain of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Structure of GSK3beta reveals a primed phosphorylation mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Identification of the TCL1 gene involved in T-cell malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Signal transduction: signaling specificity- a complex affair

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Regulation of endothelial nitric oxide synthase activity and gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901083-8

7 January 2021

10.1016/S0092-8674(02)01083-8

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12419241